[Light and electron microscope studies of the morphology of A spermatogonia in men with normal spermatogenesis and in patients treated with antiandrogens]
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[Light and electron microscope studies of the morphology of A spermatogonia in men with normal spermatogenesis and in patients treated with antiandrogens]. / Schulze, Wolfgang.
in: ANDROLOGIA, Jahrgang 10, Nr. 4, 4, 1978, S. 307-320.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [Light and electron microscope studies of the morphology of A spermatogonia in men with normal spermatogenesis and in patients treated with antiandrogens]
AU - Schulze, Wolfgang
PY - 1978
Y1 - 1978
N2 - Based on cytological criteria, three types of A-Spermatogonia may be distinguished in the germinal epithelium of normal men. Cells belonging to Type I conform to A pale spermatogonia and those classified as Type II conform to A dark-spermatogonia according to Clermont ()963). Type III-spermatogonia do not meet the criteria set up by Clermont. Quantitative analysis of the germinal epithelium of two normal men indicates that 50% of the A-spermatogonia may be classified as Type I, 20% as Type II and 30% as Type III-spermatogonia. Type II-spermatogonia appear preferentially reduced in men treated with antiandrogens. In one of the two cases, Type I-spermatogonia were found to have increased to as much as 88%. At the same time, Type III-spermatogonia appeared to have decreased to 12%. Thus, Type II-cells were eliminated from the germinal epithelium. Long-term treatment with antiandrogens also altered the morphology of organelles in the spermatogonia. Based on these findings, a new concept concerning the sequence of events in the spermatogoniogenesis is advanced.
AB - Based on cytological criteria, three types of A-Spermatogonia may be distinguished in the germinal epithelium of normal men. Cells belonging to Type I conform to A pale spermatogonia and those classified as Type II conform to A dark-spermatogonia according to Clermont ()963). Type III-spermatogonia do not meet the criteria set up by Clermont. Quantitative analysis of the germinal epithelium of two normal men indicates that 50% of the A-spermatogonia may be classified as Type I, 20% as Type II and 30% as Type III-spermatogonia. Type II-spermatogonia appear preferentially reduced in men treated with antiandrogens. In one of the two cases, Type I-spermatogonia were found to have increased to as much as 88%. At the same time, Type III-spermatogonia appeared to have decreased to 12%. Thus, Type II-cells were eliminated from the germinal epithelium. Long-term treatment with antiandrogens also altered the morphology of organelles in the spermatogonia. Based on these findings, a new concept concerning the sequence of events in the spermatogoniogenesis is advanced.
M3 - SCORING: Zeitschriftenaufsatz
VL - 10
SP - 307
EP - 320
JO - ANDROLOGIA
JF - ANDROLOGIA
SN - 0303-4569
IS - 4
M1 - 4
ER -