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Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"?

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Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"? / Tiede, Stephan; Paus, Ralf.

in: BIOESSAYS, Jahrgang 28, Nr. 12, 12.2006, S. 1157-60.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Tiede, S & Paus, R 2006, 'Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"?', BIOESSAYS, Jg. 28, Nr. 12, S. 1157-60. https://doi.org/10.1002/bies.20506

APA

Tiede, S., & Paus, R. (2006). Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"? BIOESSAYS, 28(12), 1157-60. https://doi.org/10.1002/bies.20506

Vancouver

Tiede S, Paus R. Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"? BIOESSAYS. 2006 Dez;28(12):1157-60. https://doi.org/10.1002/bies.20506

Bibtex

@article{594573b19a074852b57fc5ebde81d61e,
title = "Lhx2--decisive role in epithelial stem cell maintenance, or just the {"}tip of the iceberg{"}?",
abstract = "Stem cell self renewal, maintenance and differentiation are influenced by the convergence of intrinsic cellular signals and extrinsic microenvironmental cues from the surrounding stem cell niche. However, the specific signals involved are often still poorly understood. This is also true for skin epithelial stem cells. Recently, by transcriptionally profiling of embryonic hair progenitors in mice, Rhee et al. have managed to define how murine hair follicle epithelial stem cells are specified and maintained in an undifferentiated state. These authors have identified Lhx2 as a transcription factor functionally positioned downstream of signals necessary to specify hair follicle stem cells such as p63 or NFkappaB, but upstream of signals like Wnt/beta-catenin, Bmp or Shh that are required to drive activated stem cells via the production of transient amplifying cells into terminal differentiation.",
keywords = "Animals, Epithelial Cells, Hair Follicle, Humans, Signal Transduction, Stem Cells, Transcription Factors, Journal Article, Review",
author = "Stephan Tiede and Ralf Paus",
year = "2006",
month = dec,
doi = "10.1002/bies.20506",
language = "English",
volume = "28",
pages = "1157--60",
journal = "BIOESSAYS",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"?

AU - Tiede, Stephan

AU - Paus, Ralf

PY - 2006/12

Y1 - 2006/12

N2 - Stem cell self renewal, maintenance and differentiation are influenced by the convergence of intrinsic cellular signals and extrinsic microenvironmental cues from the surrounding stem cell niche. However, the specific signals involved are often still poorly understood. This is also true for skin epithelial stem cells. Recently, by transcriptionally profiling of embryonic hair progenitors in mice, Rhee et al. have managed to define how murine hair follicle epithelial stem cells are specified and maintained in an undifferentiated state. These authors have identified Lhx2 as a transcription factor functionally positioned downstream of signals necessary to specify hair follicle stem cells such as p63 or NFkappaB, but upstream of signals like Wnt/beta-catenin, Bmp or Shh that are required to drive activated stem cells via the production of transient amplifying cells into terminal differentiation.

AB - Stem cell self renewal, maintenance and differentiation are influenced by the convergence of intrinsic cellular signals and extrinsic microenvironmental cues from the surrounding stem cell niche. However, the specific signals involved are often still poorly understood. This is also true for skin epithelial stem cells. Recently, by transcriptionally profiling of embryonic hair progenitors in mice, Rhee et al. have managed to define how murine hair follicle epithelial stem cells are specified and maintained in an undifferentiated state. These authors have identified Lhx2 as a transcription factor functionally positioned downstream of signals necessary to specify hair follicle stem cells such as p63 or NFkappaB, but upstream of signals like Wnt/beta-catenin, Bmp or Shh that are required to drive activated stem cells via the production of transient amplifying cells into terminal differentiation.

KW - Animals

KW - Epithelial Cells

KW - Hair Follicle

KW - Humans

KW - Signal Transduction

KW - Stem Cells

KW - Transcription Factors

KW - Journal Article

KW - Review

U2 - 10.1002/bies.20506

DO - 10.1002/bies.20506

M3 - SCORING: Review article

C2 - 17117482

VL - 28

SP - 1157

EP - 1160

JO - BIOESSAYS

JF - BIOESSAYS

SN - 0265-9247

IS - 12

ER -