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Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

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Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex. / Gläscher, Jan; Adolphs, Ralph; Damasio, Hanna; Bechara, Antoine; Rudrauf, David; Calamia, Matthew; Paul, Lynn K; Tranel, Daniel.

in: P NATL ACAD SCI USA, Jahrgang 109, Nr. 36, 36, 04.09.2012, S. 14681-14686.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gläscher, J, Adolphs, R, Damasio, H, Bechara, A, Rudrauf, D, Calamia, M, Paul, LK & Tranel, D 2012, 'Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex', P NATL ACAD SCI USA, Jg. 109, Nr. 36, 36, S. 14681-14686. https://doi.org/10.1073/pnas.1206608109

APA

Gläscher, J., Adolphs, R., Damasio, H., Bechara, A., Rudrauf, D., Calamia, M., Paul, L. K., & Tranel, D. (2012). Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex. P NATL ACAD SCI USA, 109(36), 14681-14686. [36]. https://doi.org/10.1073/pnas.1206608109

Vancouver

Gläscher J, Adolphs R, Damasio H, Bechara A, Rudrauf D, Calamia M et al. Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex. P NATL ACAD SCI USA. 2012 Sep 4;109(36):14681-14686. 36. https://doi.org/10.1073/pnas.1206608109

Bibtex

@article{406f99aeccb045259db6f899574d6073,
title = "Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex",
abstract = "A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several decades. We applied voxel-based lesion-symptom mapping in 344 individuals with focal lesions (165 involving the PFC) who had been tested on a comprehensive battery of neuropsychological tasks. Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching), which included the dorsolateral prefrontal cortex and anterior cingulate cortex and a second associated with value-based decision-making, which included the orbitofrontal, ventromedial, and frontopolar cortex. Furthermore, cognitive control tasks shared a common performance factor related to set shifting that was linked to the rostral anterior cingulate cortex. By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC.",
keywords = "Humans, Neuropsychological Tests, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Linear Models, Nerve Net/*physiology, Decision Making/*physiology, Cognition/*physiology, Executive Function/physiology, Gyrus Cinguli/physiology, Iowa, Prefrontal Cortex/*pathology/*physiology, *Social Values, Humans, Neuropsychological Tests, Magnetic Resonance Imaging, Tomography, X-Ray Computed, Linear Models, Nerve Net/*physiology, Decision Making/*physiology, Cognition/*physiology, Executive Function/physiology, Gyrus Cinguli/physiology, Iowa, Prefrontal Cortex/*pathology/*physiology, *Social Values",
author = "Jan Gl{\"a}scher and Ralph Adolphs and Hanna Damasio and Antoine Bechara and David Rudrauf and Matthew Calamia and Paul, {Lynn K} and Daniel Tranel",
year = "2012",
month = sep,
day = "4",
doi = "10.1073/pnas.1206608109",
language = "English",
volume = "109",
pages = "14681--14686",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "36",

}

RIS

TY - JOUR

T1 - Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex

AU - Gläscher, Jan

AU - Adolphs, Ralph

AU - Damasio, Hanna

AU - Bechara, Antoine

AU - Rudrauf, David

AU - Calamia, Matthew

AU - Paul, Lynn K

AU - Tranel, Daniel

PY - 2012/9/4

Y1 - 2012/9/4

N2 - A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several decades. We applied voxel-based lesion-symptom mapping in 344 individuals with focal lesions (165 involving the PFC) who had been tested on a comprehensive battery of neuropsychological tasks. Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching), which included the dorsolateral prefrontal cortex and anterior cingulate cortex and a second associated with value-based decision-making, which included the orbitofrontal, ventromedial, and frontopolar cortex. Furthermore, cognitive control tasks shared a common performance factor related to set shifting that was linked to the rostral anterior cingulate cortex. By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC.

AB - A considerable body of previous research on the prefrontal cortex (PFC) has helped characterize the regional specificity of various cognitive functions, such as cognitive control and decision making. Here we provide definitive findings on this topic, using a neuropsychological approach that takes advantage of a unique dataset accrued over several decades. We applied voxel-based lesion-symptom mapping in 344 individuals with focal lesions (165 involving the PFC) who had been tested on a comprehensive battery of neuropsychological tasks. Two distinct functional-anatomical networks were revealed within the PFC: one associated with cognitive control (response inhibition, conflict monitoring, and switching), which included the dorsolateral prefrontal cortex and anterior cingulate cortex and a second associated with value-based decision-making, which included the orbitofrontal, ventromedial, and frontopolar cortex. Furthermore, cognitive control tasks shared a common performance factor related to set shifting that was linked to the rostral anterior cingulate cortex. By contrast, regions in the ventral PFC were required for decision-making. These findings provide detailed causal evidence for a remarkable functional-anatomical specificity in the human PFC.

KW - Humans

KW - Neuropsychological Tests

KW - Magnetic Resonance Imaging

KW - Tomography, X-Ray Computed

KW - Linear Models

KW - Nerve Net/physiology

KW - Decision Making/physiology

KW - Cognition/physiology

KW - Executive Function/physiology

KW - Gyrus Cinguli/physiology

KW - Iowa

KW - Prefrontal Cortex/pathology/physiology

KW - Social Values

KW - Humans

KW - Neuropsychological Tests

KW - Magnetic Resonance Imaging

KW - Tomography, X-Ray Computed

KW - Linear Models

KW - Nerve Net/physiology

KW - Decision Making/physiology

KW - Cognition/physiology

KW - Executive Function/physiology

KW - Gyrus Cinguli/physiology

KW - Iowa

KW - Prefrontal Cortex/pathology/physiology

KW - Social Values

U2 - 10.1073/pnas.1206608109

DO - 10.1073/pnas.1206608109

M3 - SCORING: Journal article

C2 - 22908286

VL - 109

SP - 14681

EP - 14686

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 36

M1 - 36

ER -