Lenalidomide in relapsed and refractory multiple myeloma disease: feasibility and benefits of long-term treatment
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Lenalidomide in relapsed and refractory multiple myeloma disease: feasibility and benefits of long-term treatment. / Zago, Manola; Oehrlein, Katharina; Rendl, Corinna; Hahn-Ast, Corinna; Kanz, Lothar; Weisel, Katja.
in: ANN HEMATOL, Jahrgang 93, Nr. 12, 12.2014, S. 1993-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Lenalidomide in relapsed and refractory multiple myeloma disease: feasibility and benefits of long-term treatment
AU - Zago, Manola
AU - Oehrlein, Katharina
AU - Rendl, Corinna
AU - Hahn-Ast, Corinna
AU - Kanz, Lothar
AU - Weisel, Katja
PY - 2014/12
Y1 - 2014/12
N2 - Lenalidomide in combination with dexamethasone is an effective and well-established treatment of relapsed or refractory multiple myeloma (rrMM) disease. Due to the scarcity of reports assessing benefit and risk of long-term lenalidomide treatment in non-selected rrMM patients, we retrospectively analysed the long-term outcome in patients with rrMM treated with lenalidomide and dexamethasone. Sixty-seven patients (pts) who were treated with lenalidomide/dexamethasone for rrMM in the approved indication from 2007 to 2011 were included in this retrospective, single-centre analysis. Kaplan-Meier survival estimates were compared between total population, patients on lenalidomide for more than 12 months (mo) and patients discontinuing therapy earlier than 12 months. Median overall survival (OS) of the total patient population was 33.2 mo. OS of pts treated beyond 12 mo was 42.9 mo compared to 20.2 mo (p = 0.027) for pts stopping lenalidomide earlier than 12 mo for other reasons than progression disease (PD). OS of pts >12 mo on lenalidomide treatment did not significantly differ between pts who had received previous autologous transplantation, allogeneic transplantation or conventional therapy. Main non-hematologic toxicities were infections of grade 3/4 in 25 % and thrombembolic events of all grades in 18 % of patients. To the best of our knowledge, this is the first report on feasibility and efficacy of long-term lenalidomide treatment in a non-selected patient cohort. OS of pts >12 mo on lenalidomide is superior when compared to pts discontinued earlier for reasons other than PD. Our data confirm the current use of lenalidomide as a continuous long-term treatment strategy.
AB - Lenalidomide in combination with dexamethasone is an effective and well-established treatment of relapsed or refractory multiple myeloma (rrMM) disease. Due to the scarcity of reports assessing benefit and risk of long-term lenalidomide treatment in non-selected rrMM patients, we retrospectively analysed the long-term outcome in patients with rrMM treated with lenalidomide and dexamethasone. Sixty-seven patients (pts) who were treated with lenalidomide/dexamethasone for rrMM in the approved indication from 2007 to 2011 were included in this retrospective, single-centre analysis. Kaplan-Meier survival estimates were compared between total population, patients on lenalidomide for more than 12 months (mo) and patients discontinuing therapy earlier than 12 months. Median overall survival (OS) of the total patient population was 33.2 mo. OS of pts treated beyond 12 mo was 42.9 mo compared to 20.2 mo (p = 0.027) for pts stopping lenalidomide earlier than 12 mo for other reasons than progression disease (PD). OS of pts >12 mo on lenalidomide treatment did not significantly differ between pts who had received previous autologous transplantation, allogeneic transplantation or conventional therapy. Main non-hematologic toxicities were infections of grade 3/4 in 25 % and thrombembolic events of all grades in 18 % of patients. To the best of our knowledge, this is the first report on feasibility and efficacy of long-term lenalidomide treatment in a non-selected patient cohort. OS of pts >12 mo on lenalidomide is superior when compared to pts discontinued earlier for reasons other than PD. Our data confirm the current use of lenalidomide as a continuous long-term treatment strategy.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Allografts
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Boronic Acids
KW - Bortezomib
KW - Chromosome Aberrations
KW - Dexamethasone
KW - Disease Progression
KW - Drug Evaluation
KW - Feasibility Studies
KW - Female
KW - Hematologic Diseases
KW - Hematopoietic Stem Cell Transplantation
KW - Humans
KW - Kaplan-Meier Estimate
KW - Lenalidomide
KW - Male
KW - Middle Aged
KW - Multiple Myeloma
KW - Pyrazines
KW - Recurrence
KW - Retrospective Studies
KW - Salvage Therapy
KW - Sensation Disorders
KW - Thalidomide
KW - Thromboembolism
KW - Transplantation, Autologous
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1007/s00277-014-2149-2
DO - 10.1007/s00277-014-2149-2
M3 - SCORING: Journal article
C2 - 24974802
VL - 93
SP - 1993
EP - 1999
JO - ANN HEMATOL
JF - ANN HEMATOL
SN - 0939-5555
IS - 12
ER -
