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Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR

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Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR. / Chen, Hang; Brunner, Fabian J; Özden, Cansu; Wenzel, Ulrich O; Neumann, Johannes T; Erley, Jennifer; Saering, Dennis; Muellerleile, Kai; Maas, Kai-Jonathan; Schoennagel, Bjoern P; Cavus, Ersin; Schneider, Jan N; Blankenberg, Stefan; Koops, Andreas; Adam, Gerhard; Tahir, Enver.

in: EUR RADIOL, Jahrgang 33, Nr. 9, 09.2023, S. 6278-6289.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chen, H, Brunner, FJ, Özden, C, Wenzel, UO, Neumann, JT, Erley, J, Saering, D, Muellerleile, K, Maas, K-J, Schoennagel, BP, Cavus, E, Schneider, JN, Blankenberg, S, Koops, A, Adam, G & Tahir, E 2023, 'Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR', EUR RADIOL, Jg. 33, Nr. 9, S. 6278-6289. https://doi.org/10.1007/s00330-023-09595-z

APA

Chen, H., Brunner, F. J., Özden, C., Wenzel, U. O., Neumann, J. T., Erley, J., Saering, D., Muellerleile, K., Maas, K-J., Schoennagel, B. P., Cavus, E., Schneider, J. N., Blankenberg, S., Koops, A., Adam, G., & Tahir, E. (2023). Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR. EUR RADIOL, 33(9), 6278-6289. https://doi.org/10.1007/s00330-023-09595-z

Vancouver

Chen H, Brunner FJ, Özden C, Wenzel UO, Neumann JT, Erley J et al. Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR. EUR RADIOL. 2023 Sep;33(9):6278-6289. https://doi.org/10.1007/s00330-023-09595-z

Bibtex

@article{f873ef0f28234008a1678ac276b556d4,
title = "Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR",
abstract = "OBJECTIVES: The study aimed to investigate the alterations of myocardial deformation responding to long-standing pressure overload and the effects of focal myocardial fibrosis using feature-tracking cardiac magnetic resonance (FT-CMR) in patients with resistant hypertension (RH).METHODS: Consecutive RH patients were prospectively recruited and underwent CMR at a single institution. FT-CMR analyses based on cine images were applied to measure left ventricular (LV) peak systolic global longitudinal (GLS), radial (GRS), and circumferential strain (GCS). Functional and morphological CMR variables, and late gadolinium enhancement (LGE) imaging were also obtained.RESULTS: A total of 50 RH patients (63 ± 12 years, 32 men) and 18 normotensive controls (57 ± 8 years, 12 men) were studied. RH patients had a higher average systolic blood pressure than controls (166 ± 21 mmHg vs. 116 ± 8 mmHg, p < 0.001) with the intake of 5 ± 1 antihypertensive drugs. RH patients showed increased LV mass index (78 ± 15 g/m2 vs. 61 ± 9 g/m2, p < 0.001), decreased GLS (- 16 ± 3% vs. - 19 ± 2%, p = 0.001) and GRS (41 ± 12% vs. 48 ± 8%, p = 0.037), and GCS was reduced by trend (- 17 ± 4% vs. - 19 ± 4%, p = 0.078). Twenty-one (42%) RH patients demonstrated a LV focal myocardial fibrosis (LGE +). LGE + RH patients had higher LV mass index (85 ± 14 g/m2 vs. 73 ± 15 g/m2, p = 0.007) and attenuated GRS (37 ± 12% vs. 44 ± 12%, p = 0.048) compared to LGE - RH patients, whereas GLS (p = 0.146) and GCS (p = 0.961) were similar.CONCLUSION: Attenuation of LV GLS and GRS, and GCS decline by tendency, might be adaptative changes responding to chronic pressure overload. There is a high incidence of focal myocardial fibrosis in RH patients, which is associated with reduced LV GRS.CLINICAL RELEVANCE STATEMENT: Feature-tracking CMR-derived myocardial strain offers insights into the influence of long-standing pressure overload and of a myocardial fibrotic process on cardiac deformation in patients with resistant hypertension.KEY POINTS: • Variations of left ventricular strain are attributable to the degree of myocardial impairment in resistant hypertensive patients. • Focal myocardial fibrosis of the left ventricle is associated with attenuated global radial strain. • Feature-tracking CMR provides additional information on the attenuation of myocardial deformation responding to long-standing high blood pressure.",
keywords = "Male, Humans, Ventricular Function, Left/physiology, Heart Ventricles/diagnostic imaging, Contrast Media/pharmacology, Gadolinium, Cardiomyopathies, Hypertension/complications, Magnetic Resonance Imaging, Cine/methods, Fibrosis, Predictive Value of Tests",
author = "Hang Chen and Brunner, {Fabian J} and Cansu {\"O}zden and Wenzel, {Ulrich O} and Neumann, {Johannes T} and Jennifer Erley and Dennis Saering and Kai Muellerleile and Kai-Jonathan Maas and Schoennagel, {Bjoern P} and Ersin Cavus and Schneider, {Jan N} and Stefan Blankenberg and Andreas Koops and Gerhard Adam and Enver Tahir",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = sep,
doi = "10.1007/s00330-023-09595-z",
language = "English",
volume = "33",
pages = "6278--6289",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Left ventricular myocardial strain responding to chronic pressure overload in patients with resistant hypertension evaluated by feature-tracking CMR

AU - Chen, Hang

AU - Brunner, Fabian J

AU - Özden, Cansu

AU - Wenzel, Ulrich O

AU - Neumann, Johannes T

AU - Erley, Jennifer

AU - Saering, Dennis

AU - Muellerleile, Kai

AU - Maas, Kai-Jonathan

AU - Schoennagel, Bjoern P

AU - Cavus, Ersin

AU - Schneider, Jan N

AU - Blankenberg, Stefan

AU - Koops, Andreas

AU - Adam, Gerhard

AU - Tahir, Enver

N1 - © 2023. The Author(s).

PY - 2023/9

Y1 - 2023/9

N2 - OBJECTIVES: The study aimed to investigate the alterations of myocardial deformation responding to long-standing pressure overload and the effects of focal myocardial fibrosis using feature-tracking cardiac magnetic resonance (FT-CMR) in patients with resistant hypertension (RH).METHODS: Consecutive RH patients were prospectively recruited and underwent CMR at a single institution. FT-CMR analyses based on cine images were applied to measure left ventricular (LV) peak systolic global longitudinal (GLS), radial (GRS), and circumferential strain (GCS). Functional and morphological CMR variables, and late gadolinium enhancement (LGE) imaging were also obtained.RESULTS: A total of 50 RH patients (63 ± 12 years, 32 men) and 18 normotensive controls (57 ± 8 years, 12 men) were studied. RH patients had a higher average systolic blood pressure than controls (166 ± 21 mmHg vs. 116 ± 8 mmHg, p < 0.001) with the intake of 5 ± 1 antihypertensive drugs. RH patients showed increased LV mass index (78 ± 15 g/m2 vs. 61 ± 9 g/m2, p < 0.001), decreased GLS (- 16 ± 3% vs. - 19 ± 2%, p = 0.001) and GRS (41 ± 12% vs. 48 ± 8%, p = 0.037), and GCS was reduced by trend (- 17 ± 4% vs. - 19 ± 4%, p = 0.078). Twenty-one (42%) RH patients demonstrated a LV focal myocardial fibrosis (LGE +). LGE + RH patients had higher LV mass index (85 ± 14 g/m2 vs. 73 ± 15 g/m2, p = 0.007) and attenuated GRS (37 ± 12% vs. 44 ± 12%, p = 0.048) compared to LGE - RH patients, whereas GLS (p = 0.146) and GCS (p = 0.961) were similar.CONCLUSION: Attenuation of LV GLS and GRS, and GCS decline by tendency, might be adaptative changes responding to chronic pressure overload. There is a high incidence of focal myocardial fibrosis in RH patients, which is associated with reduced LV GRS.CLINICAL RELEVANCE STATEMENT: Feature-tracking CMR-derived myocardial strain offers insights into the influence of long-standing pressure overload and of a myocardial fibrotic process on cardiac deformation in patients with resistant hypertension.KEY POINTS: • Variations of left ventricular strain are attributable to the degree of myocardial impairment in resistant hypertensive patients. • Focal myocardial fibrosis of the left ventricle is associated with attenuated global radial strain. • Feature-tracking CMR provides additional information on the attenuation of myocardial deformation responding to long-standing high blood pressure.

AB - OBJECTIVES: The study aimed to investigate the alterations of myocardial deformation responding to long-standing pressure overload and the effects of focal myocardial fibrosis using feature-tracking cardiac magnetic resonance (FT-CMR) in patients with resistant hypertension (RH).METHODS: Consecutive RH patients were prospectively recruited and underwent CMR at a single institution. FT-CMR analyses based on cine images were applied to measure left ventricular (LV) peak systolic global longitudinal (GLS), radial (GRS), and circumferential strain (GCS). Functional and morphological CMR variables, and late gadolinium enhancement (LGE) imaging were also obtained.RESULTS: A total of 50 RH patients (63 ± 12 years, 32 men) and 18 normotensive controls (57 ± 8 years, 12 men) were studied. RH patients had a higher average systolic blood pressure than controls (166 ± 21 mmHg vs. 116 ± 8 mmHg, p < 0.001) with the intake of 5 ± 1 antihypertensive drugs. RH patients showed increased LV mass index (78 ± 15 g/m2 vs. 61 ± 9 g/m2, p < 0.001), decreased GLS (- 16 ± 3% vs. - 19 ± 2%, p = 0.001) and GRS (41 ± 12% vs. 48 ± 8%, p = 0.037), and GCS was reduced by trend (- 17 ± 4% vs. - 19 ± 4%, p = 0.078). Twenty-one (42%) RH patients demonstrated a LV focal myocardial fibrosis (LGE +). LGE + RH patients had higher LV mass index (85 ± 14 g/m2 vs. 73 ± 15 g/m2, p = 0.007) and attenuated GRS (37 ± 12% vs. 44 ± 12%, p = 0.048) compared to LGE - RH patients, whereas GLS (p = 0.146) and GCS (p = 0.961) were similar.CONCLUSION: Attenuation of LV GLS and GRS, and GCS decline by tendency, might be adaptative changes responding to chronic pressure overload. There is a high incidence of focal myocardial fibrosis in RH patients, which is associated with reduced LV GRS.CLINICAL RELEVANCE STATEMENT: Feature-tracking CMR-derived myocardial strain offers insights into the influence of long-standing pressure overload and of a myocardial fibrotic process on cardiac deformation in patients with resistant hypertension.KEY POINTS: • Variations of left ventricular strain are attributable to the degree of myocardial impairment in resistant hypertensive patients. • Focal myocardial fibrosis of the left ventricle is associated with attenuated global radial strain. • Feature-tracking CMR provides additional information on the attenuation of myocardial deformation responding to long-standing high blood pressure.

KW - Male

KW - Humans

KW - Ventricular Function, Left/physiology

KW - Heart Ventricles/diagnostic imaging

KW - Contrast Media/pharmacology

KW - Gadolinium

KW - Cardiomyopathies

KW - Hypertension/complications

KW - Magnetic Resonance Imaging, Cine/methods

KW - Fibrosis

KW - Predictive Value of Tests

U2 - 10.1007/s00330-023-09595-z

DO - 10.1007/s00330-023-09595-z

M3 - SCORING: Journal article

C2 - 37032365

VL - 33

SP - 6278

EP - 6289

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 9

ER -