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Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage

Standard

Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage. / Horstmann, Solveig; Zugck, Christian; Krumsdorf, Ulrike; Rizos, Timolaos; Rauch, Geraldine; Geis, Nicolas; Hardt, Stefan; Veltkamp, Roland.

in: NEUROLOGY, Jahrgang 82, Nr. 2, 14.01.2014, S. 135-138.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Horstmann, S, Zugck, C, Krumsdorf, U, Rizos, T, Rauch, G, Geis, N, Hardt, S & Veltkamp, R 2014, 'Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage', NEUROLOGY, Jg. 82, Nr. 2, S. 135-138. https://doi.org/10.1212/WNL.0000000000000022

APA

Horstmann, S., Zugck, C., Krumsdorf, U., Rizos, T., Rauch, G., Geis, N., Hardt, S., & Veltkamp, R. (2014). Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage. NEUROLOGY, 82(2), 135-138. https://doi.org/10.1212/WNL.0000000000000022

Vancouver

Horstmann S, Zugck C, Krumsdorf U, Rizos T, Rauch G, Geis N et al. Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage. NEUROLOGY. 2014 Jan 14;82(2):135-138. https://doi.org/10.1212/WNL.0000000000000022

Bibtex

@article{8e9c2c4a55a04e4083a8a7bc4b6ee26d,
title = "Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage",
abstract = "OBJECTIVE: To evaluate the safety and feasibility of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) and previous intracranial hemorrhage (ICH).METHODS: In an explorative, prospective, single-center, observational study, LAAO was performed in patients with previous ICH and AF using the Amplatzer Cardiac Plug device. Risks of ischemic strokes and hemorrhagic complications were estimated using the CHA2DS2Vasc score and the HAS-BLED score. Before and 1, 6, 12, and 24 months after the procedure, clinical status and complications were recorded. Major complications were predefined as periprocedural stroke, death, pericardial effusion, and device embolism.RESULTS: LAAO was performed in 20 patients. Based on CHA2DS2Vasc score (mean 4.5 ± 1.4) and HAS-BLED score (mean 4.7 ± 1.0), annual risks of stroke and hemorrhagic complications were 4.0%-6.7% and 8.7%-12.5%, respectively. No patient had a procedure-related complication. Minor postprocedural complications were observed in 4/20 patients (2 inguinal hematoma, 1 self-limiting asystole, and 1 thrombus formation on device). No ischemic or hemorrhagic stroke occurred during a mean follow-up of 13.6 ± 8.2 months.CONCLUSIONS: In this first study of LAAO in patients with previous ICH, LAAO appears feasible and safe. A larger, controlled trial is needed to assess the efficacy and safety of the procedure compared to other preventive measures.CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with a history of previous ICH and AF, percutaneous LAAO is safe and feasible.",
keywords = "Aged, Aged, 80 and over, Atrial Appendage, Atrial Fibrillation, Feasibility Studies, Female, Humans, Intracranial Hemorrhages, Male, Middle Aged, Postoperative Complications, Prospective Studies, Stroke, Therapeutic Occlusion, Treatment Outcome, Journal Article, Observational Study",
author = "Solveig Horstmann and Christian Zugck and Ulrike Krumsdorf and Timolaos Rizos and Geraldine Rauch and Nicolas Geis and Stefan Hardt and Roland Veltkamp",
year = "2014",
month = jan,
day = "14",
doi = "10.1212/WNL.0000000000000022",
language = "English",
volume = "82",
pages = "135--138",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Left atrial appendage occlusion in atrial fibrillation after intracranial hemorrhage

AU - Horstmann, Solveig

AU - Zugck, Christian

AU - Krumsdorf, Ulrike

AU - Rizos, Timolaos

AU - Rauch, Geraldine

AU - Geis, Nicolas

AU - Hardt, Stefan

AU - Veltkamp, Roland

PY - 2014/1/14

Y1 - 2014/1/14

N2 - OBJECTIVE: To evaluate the safety and feasibility of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) and previous intracranial hemorrhage (ICH).METHODS: In an explorative, prospective, single-center, observational study, LAAO was performed in patients with previous ICH and AF using the Amplatzer Cardiac Plug device. Risks of ischemic strokes and hemorrhagic complications were estimated using the CHA2DS2Vasc score and the HAS-BLED score. Before and 1, 6, 12, and 24 months after the procedure, clinical status and complications were recorded. Major complications were predefined as periprocedural stroke, death, pericardial effusion, and device embolism.RESULTS: LAAO was performed in 20 patients. Based on CHA2DS2Vasc score (mean 4.5 ± 1.4) and HAS-BLED score (mean 4.7 ± 1.0), annual risks of stroke and hemorrhagic complications were 4.0%-6.7% and 8.7%-12.5%, respectively. No patient had a procedure-related complication. Minor postprocedural complications were observed in 4/20 patients (2 inguinal hematoma, 1 self-limiting asystole, and 1 thrombus formation on device). No ischemic or hemorrhagic stroke occurred during a mean follow-up of 13.6 ± 8.2 months.CONCLUSIONS: In this first study of LAAO in patients with previous ICH, LAAO appears feasible and safe. A larger, controlled trial is needed to assess the efficacy and safety of the procedure compared to other preventive measures.CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with a history of previous ICH and AF, percutaneous LAAO is safe and feasible.

AB - OBJECTIVE: To evaluate the safety and feasibility of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) and previous intracranial hemorrhage (ICH).METHODS: In an explorative, prospective, single-center, observational study, LAAO was performed in patients with previous ICH and AF using the Amplatzer Cardiac Plug device. Risks of ischemic strokes and hemorrhagic complications were estimated using the CHA2DS2Vasc score and the HAS-BLED score. Before and 1, 6, 12, and 24 months after the procedure, clinical status and complications were recorded. Major complications were predefined as periprocedural stroke, death, pericardial effusion, and device embolism.RESULTS: LAAO was performed in 20 patients. Based on CHA2DS2Vasc score (mean 4.5 ± 1.4) and HAS-BLED score (mean 4.7 ± 1.0), annual risks of stroke and hemorrhagic complications were 4.0%-6.7% and 8.7%-12.5%, respectively. No patient had a procedure-related complication. Minor postprocedural complications were observed in 4/20 patients (2 inguinal hematoma, 1 self-limiting asystole, and 1 thrombus formation on device). No ischemic or hemorrhagic stroke occurred during a mean follow-up of 13.6 ± 8.2 months.CONCLUSIONS: In this first study of LAAO in patients with previous ICH, LAAO appears feasible and safe. A larger, controlled trial is needed to assess the efficacy and safety of the procedure compared to other preventive measures.CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with a history of previous ICH and AF, percutaneous LAAO is safe and feasible.

KW - Aged

KW - Aged, 80 and over

KW - Atrial Appendage

KW - Atrial Fibrillation

KW - Feasibility Studies

KW - Female

KW - Humans

KW - Intracranial Hemorrhages

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Prospective Studies

KW - Stroke

KW - Therapeutic Occlusion

KW - Treatment Outcome

KW - Journal Article

KW - Observational Study

U2 - 10.1212/WNL.0000000000000022

DO - 10.1212/WNL.0000000000000022

M3 - SCORING: Journal article

C2 - 24319042

VL - 82

SP - 135

EP - 138

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 2

ER -