Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome.
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Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome. / Brassen, Stefanie; Braus, Dieter F; Weber-Fahr, Wolfgang; Tost, Heike; Moritz, Steffen; Adler, Georg.
in: DEMENT GERIATR COGN, Jahrgang 18, Nr. 3-4, 3-4, 2004, S. 271-277.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Late-onset depression with mild cognitive deficits: electrophysiological evidences for a preclinical dementia syndrome.
AU - Brassen, Stefanie
AU - Braus, Dieter F
AU - Weber-Fahr, Wolfgang
AU - Tost, Heike
AU - Moritz, Steffen
AU - Adler, Georg
PY - 2004
Y1 - 2004
N2 - Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.
AB - Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.
M3 - SCORING: Zeitschriftenaufsatz
VL - 18
SP - 271
EP - 277
JO - DEMENT GERIATR COGN
JF - DEMENT GERIATR COGN
SN - 1420-8008
IS - 3-4
M1 - 3-4
ER -