Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.
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Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana. / Ehrhardt, Stephan; Eggelte, Teunis A; Kaiser, Sarah; Adjei, Lydia; Burchard, Gerd-Dieter; Anemana, Sylvester D; Bienzle, Ulrich; Mockenhaupt, Frank P.
in: ANTIMICROB AGENTS CH, Jahrgang 51, Nr. 9, 9, 2007, S. 3407-3409.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.
AU - Ehrhardt, Stephan
AU - Eggelte, Teunis A
AU - Kaiser, Sarah
AU - Adjei, Lydia
AU - Burchard, Gerd-Dieter
AU - Anemana, Sylvester D
AU - Bienzle, Ulrich
AU - Mockenhaupt, Frank P
PY - 2007
Y1 - 2007
N2 - Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.
AB - Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.
M3 - SCORING: Zeitschriftenaufsatz
VL - 51
SP - 3407
EP - 3409
JO - ANTIMICROB AGENTS CH
JF - ANTIMICROB AGENTS CH
SN - 0066-4804
IS - 9
M1 - 9
ER -