Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics
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Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics. / Härtel, Christoph; Pagel, Julia; Spiegler, Juliane; Buma, Janne; Henneke, Philipp; Zemlin, Michael; Viemann, Dorothee; Gille, Christian; Gehring, Stephan; Frommhold, David; Rupp, Jan; Herting, Egbert; Göpel, Wolfgang.
in: SCI REP-UK, Jahrgang 7, Nr. 1, 17.07.2017, S. 5633.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Lactobacillus acidophilus/Bifidobacterium infantis probiotics are associated with increased growth of VLBWI among those exposed to antibiotics
AU - Härtel, Christoph
AU - Pagel, Julia
AU - Spiegler, Juliane
AU - Buma, Janne
AU - Henneke, Philipp
AU - Zemlin, Michael
AU - Viemann, Dorothee
AU - Gille, Christian
AU - Gehring, Stephan
AU - Frommhold, David
AU - Rupp, Jan
AU - Herting, Egbert
AU - Göpel, Wolfgang
PY - 2017/7/17
Y1 - 2017/7/17
N2 - We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the administration of probiotics was independently associated with improved weight gain [g/d; effect size B = 0.62 (95% CI: 0.37-0.87), p < 0.001], and higher growth rates for body length [(mm/d; B = 0.06 (95% CI: 0.04-0.08), p < 0.001] and head circumference [mm/d; B = 0.03, 95% CI: 0.02-0.04, p < 0.001]. This effect was pronounced in infants with postnatal exposure to antibiotics; i.e. weight gain [g/d; B = 0.66 (95% CI: 0.32-1), p < 0.001], growth rate body length [(mm/d; B = 0.09 (95% CI: 0.06-0.12), p < 0.001] and head circumference [mm/d; B = 0.04, 95% CI: 0.02-0.06, p < 0.001]. In the small subgroup that was available for analysis at 5-year-follow-up (with probiotics: n = 120 vs. without probiotics: n = 54) we noted a sustained effect of probiotics in infants who received postnatal antibiotics. Probiotics may improve growth in antibiotic-treated infants which needs to be confirmed in randomized-controlled trials.
AB - We performed an observational study with very-low-birth weight infants (VLBWI) ≤33 weeks of gestation born in centers of the German Neonatal Network (GNN; (total n = 8534, n = 6229 received probiotics). The primary objectives of our study were (a) to assess the effect of Lactobacillus acidophilus/Bifidobacterium infantis probiotics on growth in VLBWI during primary stay in hospital and (b) to determine whether this effect is modified by antibiotic exposure. In linear regression models the administration of probiotics was independently associated with improved weight gain [g/d; effect size B = 0.62 (95% CI: 0.37-0.87), p < 0.001], and higher growth rates for body length [(mm/d; B = 0.06 (95% CI: 0.04-0.08), p < 0.001] and head circumference [mm/d; B = 0.03, 95% CI: 0.02-0.04, p < 0.001]. This effect was pronounced in infants with postnatal exposure to antibiotics; i.e. weight gain [g/d; B = 0.66 (95% CI: 0.32-1), p < 0.001], growth rate body length [(mm/d; B = 0.09 (95% CI: 0.06-0.12), p < 0.001] and head circumference [mm/d; B = 0.04, 95% CI: 0.02-0.06, p < 0.001]. In the small subgroup that was available for analysis at 5-year-follow-up (with probiotics: n = 120 vs. without probiotics: n = 54) we noted a sustained effect of probiotics in infants who received postnatal antibiotics. Probiotics may improve growth in antibiotic-treated infants which needs to be confirmed in randomized-controlled trials.
KW - Anti-Bacterial Agents/therapeutic use
KW - Bifidobacterium longum subspecies infantis/physiology
KW - Body Height
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Infant, Very Low Birth Weight/growth & development
KW - Lactobacillus acidophilus/physiology
KW - Length of Stay
KW - Linear Models
KW - Male
KW - Probiotics/administration & dosage
KW - Treatment Outcome
KW - Weight Gain
U2 - 10.1038/s41598-017-06161-8
DO - 10.1038/s41598-017-06161-8
M3 - SCORING: Journal article
C2 - 28717131
VL - 7
SP - 5633
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -