Lack of evidence of acute HEV infections as a sexually transmitted disease: Data from a German cohort of PrEP users
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Lack of evidence of acute HEV infections as a sexually transmitted disease: Data from a German cohort of PrEP users. / Schäfer, Guido; Lübke, Rabea; Degen, Olaf; Mader, Maria; Scheiter, Robin; Wolski, Annika; Addo, Marylyn M; Schulze Zur Wiesch, Julian; Pischke, Sven.
in: BRAZ J INFECT DIS, Jahrgang 28, Nr. 1, 2024, S. 103720.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Lack of evidence of acute HEV infections as a sexually transmitted disease: Data from a German cohort of PrEP users
AU - Schäfer, Guido
AU - Lübke, Rabea
AU - Degen, Olaf
AU - Mader, Maria
AU - Scheiter, Robin
AU - Wolski, Annika
AU - Addo, Marylyn M
AU - Schulze Zur Wiesch, Julian
AU - Pischke, Sven
N1 - Copyright © 2024 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.
PY - 2024
Y1 - 2024
N2 - BACKGROUND: While the sexual transmissibility of HAV in MSM has been extensively described, the potential for sexual transmission of HEV has not been definitively established. Although HEV has been detected in the ejaculate of chronically infected men, studies among MSM PrEP users in France did not observe an elevated anti-HEV seroprevalence as an indicator of increased exposure risk by sexual intercourse.PATIENTS AND METHODS: A total of 111 unselected PrEP users and 111 age- and sex-matched blood donors were tested for anti-HEV IgG, IgM and HEV (PCR). Of the participants 79/111 (71 %) responded to a questionnaire covering topics as sexual preferences, previous sexually transmitted diseases, profession, food consumption, and pet ownership.RESULTS: The anti-HEV IgG seroprevalence in PrEP users (22 %) did not differ significantly from the rate in controls (17 %). While one PrEP user and three controls tested positive for anti-HEV IgM, all PrEP users and controls tested PCR negative.CONCLUSION: In immunocompetent individuals with frequent changes of sexual partners, the epidemiology of Hepatitis E Virus does not significantly involve the sexual transmission route.
AB - BACKGROUND: While the sexual transmissibility of HAV in MSM has been extensively described, the potential for sexual transmission of HEV has not been definitively established. Although HEV has been detected in the ejaculate of chronically infected men, studies among MSM PrEP users in France did not observe an elevated anti-HEV seroprevalence as an indicator of increased exposure risk by sexual intercourse.PATIENTS AND METHODS: A total of 111 unselected PrEP users and 111 age- and sex-matched blood donors were tested for anti-HEV IgG, IgM and HEV (PCR). Of the participants 79/111 (71 %) responded to a questionnaire covering topics as sexual preferences, previous sexually transmitted diseases, profession, food consumption, and pet ownership.RESULTS: The anti-HEV IgG seroprevalence in PrEP users (22 %) did not differ significantly from the rate in controls (17 %). While one PrEP user and three controls tested positive for anti-HEV IgM, all PrEP users and controls tested PCR negative.CONCLUSION: In immunocompetent individuals with frequent changes of sexual partners, the epidemiology of Hepatitis E Virus does not significantly involve the sexual transmission route.
KW - Male
KW - Humans
KW - Hepatitis E virus
KW - Homosexuality, Male
KW - Seroepidemiologic Studies
KW - Hepatitis E/epidemiology
KW - Sexual and Gender Minorities
KW - Sexually Transmitted Diseases/epidemiology
KW - Hepatitis Antibodies
KW - Immunoglobulin G
KW - Immunoglobulin M
KW - HIV Infections
KW - Pre-Exposure Prophylaxis
U2 - 10.1016/j.bjid.2024.103720
DO - 10.1016/j.bjid.2024.103720
M3 - SCORING: Journal article
C2 - 38365184
VL - 28
SP - 103720
JO - BRAZ J INFECT DIS
JF - BRAZ J INFECT DIS
SN - 1413-8670
IS - 1
ER -
