Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma
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Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma. / Atac, Artun; Riecke, Björn; Assaf, Alexandre T; Gröbe, Alexander; Friedrich, Reinhard E; Heiland, Max; Izbicki, Jakob R; Kluwe, Lan; Blessmann, Marco.
in: ANTICANCER RES, Jahrgang 34, Nr. 1, 01.01.2014, S. 235-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma
AU - Atac, Artun
AU - Riecke, Björn
AU - Assaf, Alexandre T
AU - Gröbe, Alexander
AU - Friedrich, Reinhard E
AU - Heiland, Max
AU - Izbicki, Jakob R
AU - Kluwe, Lan
AU - Blessmann, Marco
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND/AIM: Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. The A allele codes for a truncated variant, cyclin D1b, which may have higher transforming activity. Data regarding the predictive and prognostic value of the CCND1 G870A polymorphism in tumors are controversial. We aimed to examine this polymorphism in patients with oral carcinoma.MATERIALS AND METHODS: Genotyping of CCND1 G870A was determined by means of direct sequencing in 83 patients with oral carcinomas and in 102 healthy controls. Association with clinical outcomes was evaluated statistically.RESULTS: We failed to find any significant association of CCND1 G870A with risk of oral carcinomas in this German population, with clinical and pathological features of the tumours or with overall survival of the patients.CONCLUSION: Our results suggest that CCND1 G870A has no, or only very limited, predictive and prognostic value for oral carcinoma.
AB - BACKGROUND/AIM: Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. The A allele codes for a truncated variant, cyclin D1b, which may have higher transforming activity. Data regarding the predictive and prognostic value of the CCND1 G870A polymorphism in tumors are controversial. We aimed to examine this polymorphism in patients with oral carcinoma.MATERIALS AND METHODS: Genotyping of CCND1 G870A was determined by means of direct sequencing in 83 patients with oral carcinomas and in 102 healthy controls. Association with clinical outcomes was evaluated statistically.RESULTS: We failed to find any significant association of CCND1 G870A with risk of oral carcinomas in this German population, with clinical and pathological features of the tumours or with overall survival of the patients.CONCLUSION: Our results suggest that CCND1 G870A has no, or only very limited, predictive and prognostic value for oral carcinoma.
KW - Carcinoma, Squamous Cell
KW - Case-Control Studies
KW - Cyclin D1
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Lymphatic Metastasis
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Neoplasm Recurrence, Local
KW - Neoplasm Staging
KW - Polymorphism, Single Nucleotide
KW - Prognosis
KW - Survival Rate
M3 - SCORING: Journal article
C2 - 24403468
VL - 34
SP - 235
EP - 238
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 1
ER -