L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma.
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L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma. / Kaifi, Jussuf; Zinnkann, Ulrich; Yekebas, Emre F; Schurr, Paulus; Reichelt, Uta; Wachowiak, Robin; Fiegel, Henning C; Petri, Susann; Schachner, Melitta; Izbicki, Jakob R.
in: WORLD J GASTROENTERO, Jahrgang 12, Nr. 1, 1, 2006, S. 94-98.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma.
AU - Kaifi, Jussuf
AU - Zinnkann, Ulrich
AU - Yekebas, Emre F
AU - Schurr, Paulus
AU - Reichelt, Uta
AU - Wachowiak, Robin
AU - Fiegel, Henning C
AU - Petri, Susann
AU - Schachner, Melitta
AU - Izbicki, Jakob R
PY - 2006
Y1 - 2006
N2 - AIM: To determine the expression of L1 in pancreatic neuroendocrine tumor and to correlate it with WHO classification of this tumor. METHODS: We retrospectively analyzed L1 expression in 63 cases of pancreatic neuroendocrine tumor by immunohistochemistry on paraffin sections of primary tumors or metastases. Staining was performed by peroxidase technique with monoclonal antibody UJ127.11 against human L1. All tumors were classified according to WHO classification as well-differentiated neuroendocrine tumors and carcinomas or poorly-differentiated neuroendocrine carcinomas. RESULTS: L1 was detected in 5 (7.9%) of 63 pancreatic neuroendocrine tumors. Four (44.4%) of 9 poorly-differentiated carcinomas expressed L1. In contrast, only 1 (1.9%) of 54 well-differentiated tumors or carcinomas was positive for L1. No expression was found in Langerhans islet cells of normal pancreatic tissue. Cross table analysis showed a significant association between L1 expression and classification of neuroendocrine tumors of the pancreas (P
AB - AIM: To determine the expression of L1 in pancreatic neuroendocrine tumor and to correlate it with WHO classification of this tumor. METHODS: We retrospectively analyzed L1 expression in 63 cases of pancreatic neuroendocrine tumor by immunohistochemistry on paraffin sections of primary tumors or metastases. Staining was performed by peroxidase technique with monoclonal antibody UJ127.11 against human L1. All tumors were classified according to WHO classification as well-differentiated neuroendocrine tumors and carcinomas or poorly-differentiated neuroendocrine carcinomas. RESULTS: L1 was detected in 5 (7.9%) of 63 pancreatic neuroendocrine tumors. Four (44.4%) of 9 poorly-differentiated carcinomas expressed L1. In contrast, only 1 (1.9%) of 54 well-differentiated tumors or carcinomas was positive for L1. No expression was found in Langerhans islet cells of normal pancreatic tissue. Cross table analysis showed a significant association between L1 expression and classification of neuroendocrine tumors of the pancreas (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 12
SP - 94
EP - 98
JO - WORLD J GASTROENTERO
JF - WORLD J GASTROENTERO
SN - 1007-9327
IS - 1
M1 - 1
ER -