PortalPublikationenKynurenic acid and kynurenine aminotransferases in retinal a...

Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration

Standard

Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration. / Rejdak, Robert; Junemann, Anselm; Grieb, Paweł; Thaler, Sebastian; Schuettauf, Frank; Chorągiewicz, Tomasz; Zarnowski, Tomasz; Turski, Waldemar A; Zrenner, Eberhart.

in: PHARMACOL REP, Jahrgang 63, Nr. 6, 2011, S. 1324-34.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Rejdak, R, Junemann, A, Grieb, P, Thaler, S, Schuettauf, F, Chorągiewicz, T, Zarnowski, T, Turski, WA & Zrenner, E 2011, 'Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration', PHARMACOL REP, Jg. 63, Nr. 6, S. 1324-34. https://doi.org/10.1016/s1734-1140(11)70697-1

APA

Rejdak, R., Junemann, A., Grieb, P., Thaler, S., Schuettauf, F., Chorągiewicz, T., Zarnowski, T., Turski, W. A., & Zrenner, E. (2011). Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration. PHARMACOL REP, 63(6), 1324-34. https://doi.org/10.1016/s1734-1140(11)70697-1

Vancouver

Rejdak R, Junemann A, Grieb P, Thaler S, Schuettauf F, Chorągiewicz T et al. Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration. PHARMACOL REP. 2011;63(6):1324-34. https://doi.org/10.1016/s1734-1140(11)70697-1

Bibtex

@article{9fa556ff2e0b42c9864bdf3584aed5dd,
title = "Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration",
abstract = "The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in avian, rodent, and human retina. Expression of KAT I in M{\"u}ller cell endfeet and KAT II in retinal ganglion cells has been documented. Developmental changes in KAT expression and KYNA concentration in the avian and rodent retina have also been found. Studies of retinal neurodegeneration have shown alterations in KYNA synthesis in the retina in response to retinal ganglion cell loss. In DBA/2J mice, a model of ocular hypertension, an age-dependent decrease of retinal KYNA and KATs was found. In the corpora amylacea in the human retina intensive KAT I and II immunoreactivity was demonstrated. In summary, these findings point to the potential involvement of KYNA in the mechanisms of retinal aging and neurodegeneration.",
keywords = "Aging/metabolism, Animals, Humans, Kynurenic Acid/metabolism, Kynurenine/metabolism, Retina/enzymology, Retinal Degeneration/enzymology, Retinal Ganglion Cells/enzymology, Transaminases/metabolism",
author = "Robert Rejdak and Anselm Junemann and Pawe{\l} Grieb and Sebastian Thaler and Frank Schuettauf and Tomasz Chor{\c a}giewicz and Tomasz Zarnowski and Turski, {Waldemar A} and Eberhart Zrenner",
year = "2011",
doi = "10.1016/s1734-1140(11)70697-1",
language = "English",
volume = "63",
pages = "1324--34",
journal = "PHARMACOL REP",
issn = "1734-1140",
publisher = "Polish Academy of Sciences Publishing House",
number = "6",

}

RIS

TY - JOUR

T1 - Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration

AU - Rejdak, Robert

AU - Junemann, Anselm

AU - Grieb, Paweł

AU - Thaler, Sebastian

AU - Schuettauf, Frank

AU - Chorągiewicz, Tomasz

AU - Zarnowski, Tomasz

AU - Turski, Waldemar A

AU - Zrenner, Eberhart

PY - 2011

Y1 - 2011

N2 - The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in avian, rodent, and human retina. Expression of KAT I in Müller cell endfeet and KAT II in retinal ganglion cells has been documented. Developmental changes in KAT expression and KYNA concentration in the avian and rodent retina have also been found. Studies of retinal neurodegeneration have shown alterations in KYNA synthesis in the retina in response to retinal ganglion cell loss. In DBA/2J mice, a model of ocular hypertension, an age-dependent decrease of retinal KYNA and KATs was found. In the corpora amylacea in the human retina intensive KAT I and II immunoreactivity was demonstrated. In summary, these findings point to the potential involvement of KYNA in the mechanisms of retinal aging and neurodegeneration.

AB - The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in avian, rodent, and human retina. Expression of KAT I in Müller cell endfeet and KAT II in retinal ganglion cells has been documented. Developmental changes in KAT expression and KYNA concentration in the avian and rodent retina have also been found. Studies of retinal neurodegeneration have shown alterations in KYNA synthesis in the retina in response to retinal ganglion cell loss. In DBA/2J mice, a model of ocular hypertension, an age-dependent decrease of retinal KYNA and KATs was found. In the corpora amylacea in the human retina intensive KAT I and II immunoreactivity was demonstrated. In summary, these findings point to the potential involvement of KYNA in the mechanisms of retinal aging and neurodegeneration.

KW - Aging/metabolism

KW - Animals

KW - Humans

KW - Kynurenic Acid/metabolism

KW - Kynurenine/metabolism

KW - Retina/enzymology

KW - Retinal Degeneration/enzymology

KW - Retinal Ganglion Cells/enzymology

KW - Transaminases/metabolism

U2 - 10.1016/s1734-1140(11)70697-1

DO - 10.1016/s1734-1140(11)70697-1

M3 - SCORING: Review article

C2 - 22358081

VL - 63

SP - 1324

EP - 1334

JO - PHARMACOL REP

JF - PHARMACOL REP

SN - 1734-1140

IS - 6

ER -