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Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors

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Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors. / Bähring, Robert.

in: CHANNELS, Jahrgang 12, Nr. 1, 2018, S. 187-200.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Bähring, R 2018, 'Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors', CHANNELS, Jg. 12, Nr. 1, S. 187-200. https://doi.org/10.1080/19336950.2018.1491243

APA

Bähring, R. (2018). Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors. CHANNELS, 12(1), 187-200. https://doi.org/10.1080/19336950.2018.1491243

Vancouver

Bähring R. Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors. CHANNELS. 2018;12(1):187-200. https://doi.org/10.1080/19336950.2018.1491243

Bibtex

@article{1d43b0dbaffe4d4aad879fdd55ac3d2d,
title = "Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors",
abstract = "Kv channel-interacting proteins (KChIPs) belong to the neuronal calcium sensor (NCS) family of Ca2+-binding EF-hand proteins. KChIPs constitute a group of specific auxiliary β-subunits for Kv4 channels, the molecular substrate of transient potassium currents in both neuronal and non-neuronal tissues. Moreover, KChIPs can interact with presenilins to control ER calcium signaling and apoptosis, and with DNA to control gene transcription. Ca2+ binding via their EF-hands, with the consequence of conformationl changes, is well documented for KChIPs. Moreover, the Ca2+ dependence of the presenilin/KChIP complex may be related to Alzheimer's disease and the Ca2+ dependence of the DNA/KChIP complex to pain sensing. However, only in few cases could the Ca2+ binding to KChIPs be directly linked to the control of excitability in nerve and muscle cells known to express Kv4/KChIP channel complexes. This review summarizes current knowledge about the Ca2+ binding properties of KChIPs and the Ca2+ dependencies of macromolecular complexes containing KChIPs, including those with presenilins, DNA and especially Kv4 channels. The respective physiological or pathophysiolgical roles of Ca2+ binding to KChIPs are discussed.",
keywords = "Journal Article",
author = "Robert B{\"a}hring",
year = "2018",
doi = "10.1080/19336950.2018.1491243",
language = "English",
volume = "12",
pages = "187--200",
journal = "CHANNELS",
issn = "1933-6950",
publisher = "LANDES BIOSCIENCE",
number = "1",

}

RIS

TY - JOUR

T1 - Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors

AU - Bähring, Robert

PY - 2018

Y1 - 2018

N2 - Kv channel-interacting proteins (KChIPs) belong to the neuronal calcium sensor (NCS) family of Ca2+-binding EF-hand proteins. KChIPs constitute a group of specific auxiliary β-subunits for Kv4 channels, the molecular substrate of transient potassium currents in both neuronal and non-neuronal tissues. Moreover, KChIPs can interact with presenilins to control ER calcium signaling and apoptosis, and with DNA to control gene transcription. Ca2+ binding via their EF-hands, with the consequence of conformationl changes, is well documented for KChIPs. Moreover, the Ca2+ dependence of the presenilin/KChIP complex may be related to Alzheimer's disease and the Ca2+ dependence of the DNA/KChIP complex to pain sensing. However, only in few cases could the Ca2+ binding to KChIPs be directly linked to the control of excitability in nerve and muscle cells known to express Kv4/KChIP channel complexes. This review summarizes current knowledge about the Ca2+ binding properties of KChIPs and the Ca2+ dependencies of macromolecular complexes containing KChIPs, including those with presenilins, DNA and especially Kv4 channels. The respective physiological or pathophysiolgical roles of Ca2+ binding to KChIPs are discussed.

AB - Kv channel-interacting proteins (KChIPs) belong to the neuronal calcium sensor (NCS) family of Ca2+-binding EF-hand proteins. KChIPs constitute a group of specific auxiliary β-subunits for Kv4 channels, the molecular substrate of transient potassium currents in both neuronal and non-neuronal tissues. Moreover, KChIPs can interact with presenilins to control ER calcium signaling and apoptosis, and with DNA to control gene transcription. Ca2+ binding via their EF-hands, with the consequence of conformationl changes, is well documented for KChIPs. Moreover, the Ca2+ dependence of the presenilin/KChIP complex may be related to Alzheimer's disease and the Ca2+ dependence of the DNA/KChIP complex to pain sensing. However, only in few cases could the Ca2+ binding to KChIPs be directly linked to the control of excitability in nerve and muscle cells known to express Kv4/KChIP channel complexes. This review summarizes current knowledge about the Ca2+ binding properties of KChIPs and the Ca2+ dependencies of macromolecular complexes containing KChIPs, including those with presenilins, DNA and especially Kv4 channels. The respective physiological or pathophysiolgical roles of Ca2+ binding to KChIPs are discussed.

KW - Journal Article

U2 - 10.1080/19336950.2018.1491243

DO - 10.1080/19336950.2018.1491243

M3 - SCORING: Review article

C2 - 30070159

VL - 12

SP - 187

EP - 200

JO - CHANNELS

JF - CHANNELS

SN - 1933-6950

IS - 1

ER -