Kidneys control inter-organ homeostasis
Beteiligte Einrichtungen
Abstract
Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic peptide GDF15. These findings link kidney injury to cachexia and highlight the role of the kidney in mediating inter-organ homeostasis.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1759-5061 |
DOIs | |
Status | Veröffentlicht - 04.2022 |
PubMed | 35165430 |
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