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ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso

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ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso. / Kynast-Wolf, Gisela; Wakilzadeh, Wieda; Coulibaly, Boubacar; Schnitzler, Paul; Traoré, Corneille; Becher, Heiko; Müller, Olaf.

in: ACTA TROP, Jahrgang 123, Nr. 2, 01.08.2012, S. 117-22.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kynast-Wolf, G, Wakilzadeh, W, Coulibaly, B, Schnitzler, P, Traoré, C, Becher, H & Müller, O 2012, 'ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso', ACTA TROP, Jg. 123, Nr. 2, S. 117-22. https://doi.org/10.1016/j.actatropica.2012.04.010

APA

Kynast-Wolf, G., Wakilzadeh, W., Coulibaly, B., Schnitzler, P., Traoré, C., Becher, H., & Müller, O. (2012). ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso. ACTA TROP, 123(2), 117-22. https://doi.org/10.1016/j.actatropica.2012.04.010

Vancouver

Kynast-Wolf G, Wakilzadeh W, Coulibaly B, Schnitzler P, Traoré C, Becher H et al. ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso. ACTA TROP. 2012 Aug 1;123(2):117-22. https://doi.org/10.1016/j.actatropica.2012.04.010

Bibtex

@article{66e81104bbb743a5bb02a629f22b84df,
title = "ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso",
abstract = "Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP1(42) antibodies (ELISA based on recombinant 42kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP1(42) antibody titres. MSP1(42) antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP1(42) antibody titres at any point in time (101 vs. 97 days in May, p=0.6; 58 vs. 84 days in September, p=0.3; 144 vs. 161 days in March, p=0.5). The findings of this study support the short-lived nature of the humoral immune response in infants of malaria endemic areas. The study provides no evidence for antibodies against a subunit of MSP1 being protective against new malaria episodes in infants.",
keywords = "Antibodies, Protozoan, Burkina Faso, Cohort Studies, Female, Humans, Infant, Insecticide-Treated Bednets, Insecticides, Malaria, Falciparum, Male, Merozoite Surface Protein 1, Plasmodium falciparum, Prospective Studies, Rural Population, Treatment Outcome",
author = "Gisela Kynast-Wolf and Wieda Wakilzadeh and Boubacar Coulibaly and Paul Schnitzler and Corneille Traor{\'e} and Heiko Becher and Olaf M{\"u}ller",
note = "Copyright {\textcopyright} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
month = aug,
day = "1",
doi = "10.1016/j.actatropica.2012.04.010",
language = "English",
volume = "123",
pages = "117--22",
journal = "ACTA TROP",
issn = "0001-706X",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - ITN protection, MSP1 antibody levels and malaria episodes in young children of rural Burkina Faso

AU - Kynast-Wolf, Gisela

AU - Wakilzadeh, Wieda

AU - Coulibaly, Boubacar

AU - Schnitzler, Paul

AU - Traoré, Corneille

AU - Becher, Heiko

AU - Müller, Olaf

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP1(42) antibodies (ELISA based on recombinant 42kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP1(42) antibody titres. MSP1(42) antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP1(42) antibody titres at any point in time (101 vs. 97 days in May, p=0.6; 58 vs. 84 days in September, p=0.3; 144 vs. 161 days in March, p=0.5). The findings of this study support the short-lived nature of the humoral immune response in infants of malaria endemic areas. The study provides no evidence for antibodies against a subunit of MSP1 being protective against new malaria episodes in infants.

AB - Malaria blood-stage vaccines are in an early phase of clinical development with MSP1 being a major antigen candidate. There are limited data on the protective efficacy of antibodies against subunits of MSP1 in the malaria endemic areas of sub-Saharan Africa. This prospective cohort study was nested into a large insecticide-treated mosquito net (ITN) trial during which neonates were individually randomised to ITN protection from birth vs. protection from month six onwards in rural Burkina Faso. A sub sample of 120 children from three villages was followed for 10 months with six measurements of MSP1(42) antibodies (ELISA based on recombinant 42kDa fragment) and daily assessment of malaria episodes. Time to the next malaria episode was determined in relation to MSP1(42) antibody titres. MSP1(42) antibody titres were dependent on age, season, ITN-group, number of previous malaria episodes and parasitaemia. There were no significant differences in time until the next malaria episode in children with low compared to children with high MSP1(42) antibody titres at any point in time (101 vs. 97 days in May, p=0.6; 58 vs. 84 days in September, p=0.3; 144 vs. 161 days in March, p=0.5). The findings of this study support the short-lived nature of the humoral immune response in infants of malaria endemic areas. The study provides no evidence for antibodies against a subunit of MSP1 being protective against new malaria episodes in infants.

KW - Antibodies, Protozoan

KW - Burkina Faso

KW - Cohort Studies

KW - Female

KW - Humans

KW - Infant

KW - Insecticide-Treated Bednets

KW - Insecticides

KW - Malaria, Falciparum

KW - Male

KW - Merozoite Surface Protein 1

KW - Plasmodium falciparum

KW - Prospective Studies

KW - Rural Population

KW - Treatment Outcome

U2 - 10.1016/j.actatropica.2012.04.010

DO - 10.1016/j.actatropica.2012.04.010

M3 - SCORING: Journal article

C2 - 22569564

VL - 123

SP - 117

EP - 122

JO - ACTA TROP

JF - ACTA TROP

SN - 0001-706X

IS - 2

ER -