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Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

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Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data. / Birkner, Thomas; Siegels, Doreen; Heinrich, Luise; Haufe, Eva; Abraham, Susanne; Heratizadeh, Annice; Harder, Inken; Bell, Magnus; Fell, Isabell; Worm, Margitta; Handrick, Christiane; Effendy, Isaak; Asmussen, Andrea; Kleinheinz, Andreas; Homey, Bernhard; Sticherling, Michael; Hong-Weldemann, Sung-Hei; Augustin, Matthias; Weisshaar, Elke; Schäkel, Knut; Schaefer, Thomas; Schwarz, Beate; Wiemers, Franca; Brücher, Jens-Joachim; Quist, Sven; Wollenberg, Andreas; Biedermann, Tilo; Ertner, Konstantin; von Kiedrowski, Ralph; Werfel, Thomas; Weidinger, Stephan; Schmitt, Jochen; TREATgermany study group.

in: J DTSCH DERMATOL GES, Jahrgang 21, Nr. 10, 10.2023, S. 1157-1168.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Birkner, T, Siegels, D, Heinrich, L, Haufe, E, Abraham, S, Heratizadeh, A, Harder, I, Bell, M, Fell, I, Worm, M, Handrick, C, Effendy, I, Asmussen, A, Kleinheinz, A, Homey, B, Sticherling, M, Hong-Weldemann, S-H, Augustin, M, Weisshaar, E, Schäkel, K, Schaefer, T, Schwarz, B, Wiemers, F, Brücher, J-J, Quist, S, Wollenberg, A, Biedermann, T, Ertner, K, von Kiedrowski, R, Werfel, T, Weidinger, S, Schmitt, J & TREATgermany study group 2023, 'Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data', J DTSCH DERMATOL GES, Jg. 21, Nr. 10, S. 1157-1168. https://doi.org/10.1111/ddg.15159

APA

Birkner, T., Siegels, D., Heinrich, L., Haufe, E., Abraham, S., Heratizadeh, A., Harder, I., Bell, M., Fell, I., Worm, M., Handrick, C., Effendy, I., Asmussen, A., Kleinheinz, A., Homey, B., Sticherling, M., Hong-Weldemann, S-H., Augustin, M., Weisshaar, E., ... TREATgermany study group (2023). Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data. J DTSCH DERMATOL GES, 21(10), 1157-1168. https://doi.org/10.1111/ddg.15159

Vancouver

Birkner T, Siegels D, Heinrich L, Haufe E, Abraham S, Heratizadeh A et al. Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data. J DTSCH DERMATOL GES. 2023 Okt;21(10):1157-1168. https://doi.org/10.1111/ddg.15159

Bibtex

@article{f2b63ff10e68486a97a8c94601e92f1f,
title = "Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data",
abstract = "BACKGROUND: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.METHODS: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.RESULTS: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).CONCLUSIONS: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.",
keywords = "Adult, Humans, Dermatitis, Atopic/diagnosis, Quality of Life, Depression/epidemiology, Routinely Collected Health Data, Pruritus/etiology, Severity of Illness Index, Sleep, Fatigue/epidemiology",
author = "Thomas Birkner and Doreen Siegels and Luise Heinrich and Eva Haufe and Susanne Abraham and Annice Heratizadeh and Inken Harder and Magnus Bell and Isabell Fell and Margitta Worm and Christiane Handrick and Isaak Effendy and Andrea Asmussen and Andreas Kleinheinz and Bernhard Homey and Michael Sticherling and Sung-Hei Hong-Weldemann and Matthias Augustin and Elke Weisshaar and Knut Sch{\"a}kel and Thomas Schaefer and Beate Schwarz and Franca Wiemers and Jens-Joachim Br{\"u}cher and Sven Quist and Andreas Wollenberg and Tilo Biedermann and Konstantin Ertner and {von Kiedrowski}, Ralph and Thomas Werfel and Stephan Weidinger and Jochen Schmitt and {TREATgermany study group}",
note = "{\textcopyright} 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.",
year = "2023",
month = oct,
doi = "10.1111/ddg.15159",
language = "English",
volume = "21",
pages = "1157--1168",
journal = "J DTSCH DERMATOL GES",
issn = "1610-0379",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

AU - Birkner, Thomas

AU - Siegels, Doreen

AU - Heinrich, Luise

AU - Haufe, Eva

AU - Abraham, Susanne

AU - Heratizadeh, Annice

AU - Harder, Inken

AU - Bell, Magnus

AU - Fell, Isabell

AU - Worm, Margitta

AU - Handrick, Christiane

AU - Effendy, Isaak

AU - Asmussen, Andrea

AU - Kleinheinz, Andreas

AU - Homey, Bernhard

AU - Sticherling, Michael

AU - Hong-Weldemann, Sung-Hei

AU - Augustin, Matthias

AU - Weisshaar, Elke

AU - Schäkel, Knut

AU - Schaefer, Thomas

AU - Schwarz, Beate

AU - Wiemers, Franca

AU - Brücher, Jens-Joachim

AU - Quist, Sven

AU - Wollenberg, Andreas

AU - Biedermann, Tilo

AU - Ertner, Konstantin

AU - von Kiedrowski, Ralph

AU - Werfel, Thomas

AU - Weidinger, Stephan

AU - Schmitt, Jochen

AU - TREATgermany study group

N1 - © 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.

PY - 2023/10

Y1 - 2023/10

N2 - BACKGROUND: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.METHODS: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.RESULTS: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).CONCLUSIONS: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.

AB - BACKGROUND: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.METHODS: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.RESULTS: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).CONCLUSIONS: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.

KW - Adult

KW - Humans

KW - Dermatitis, Atopic/diagnosis

KW - Quality of Life

KW - Depression/epidemiology

KW - Routinely Collected Health Data

KW - Pruritus/etiology

KW - Severity of Illness Index

KW - Sleep

KW - Fatigue/epidemiology

U2 - 10.1111/ddg.15159

DO - 10.1111/ddg.15159

M3 - SCORING: Journal article

C2 - 37485573

VL - 21

SP - 1157

EP - 1168

JO - J DTSCH DERMATOL GES

JF - J DTSCH DERMATOL GES

SN - 1610-0379

IS - 10

ER -