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Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge

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Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. / Kolesnikova, Sophia A; Lyakhova, Ekaterina G; Kalinovsky, Anatoly I; Pushilin, Michail A; Afiyatullov, Shamil Sh; Yurchenko, Ekaterina A; Dyshlovoy, Sergey A; Minh, Chau V; Stonik, Valentin A.

in: J NAT PROD, Jahrgang 76, Nr. 9, 27.09.2013, S. 1746-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kolesnikova, SA, Lyakhova, EG, Kalinovsky, AI, Pushilin, MA, Afiyatullov, SS, Yurchenko, EA, Dyshlovoy, SA, Minh, CV & Stonik, VA 2013, 'Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge', J NAT PROD, Jg. 76, Nr. 9, S. 1746-52. https://doi.org/10.1021/np400388x

APA

Kolesnikova, S. A., Lyakhova, E. G., Kalinovsky, A. I., Pushilin, M. A., Afiyatullov, S. S., Yurchenko, E. A., Dyshlovoy, S. A., Minh, C. V., & Stonik, V. A. (2013). Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. J NAT PROD, 76(9), 1746-52. https://doi.org/10.1021/np400388x

Vancouver

Kolesnikova SA, Lyakhova EG, Kalinovsky AI, Pushilin MA, Afiyatullov SS, Yurchenko EA et al. Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. J NAT PROD. 2013 Sep 27;76(9):1746-52. https://doi.org/10.1021/np400388x

Bibtex

@article{26d6421483ab4071aae4ea50c6796645,
title = "Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge",
abstract = "Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Configurations of the triterpene epoxy lactones (1-4) were determined on the basis of NOESY and CD data and calculation of spin coupling constants and confirmed by X-ray crystallographic analysis of compound 2. The isolated triterpenoid 6 was cytotoxic against human leukemia HL-60 cells (IC₅₀ = 9.7 μM).",
keywords = "Animals, Antineoplastic Agents, Crystallography, X-Ray, Drug Screening Assays, Antitumor, HL-60 Cells, Humans, Lanosterol, Marine Biology, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Porifera, Triterpenes, Vietnam, Journal Article, Research Support, Non-U.S. Gov't",
author = "Kolesnikova, {Sophia A} and Lyakhova, {Ekaterina G} and Kalinovsky, {Anatoly I} and Pushilin, {Michail A} and Afiyatullov, {Shamil Sh} and Yurchenko, {Ekaterina A} and Dyshlovoy, {Sergey A} and Minh, {Chau V} and Stonik, {Valentin A}",
year = "2013",
month = sep,
day = "27",
doi = "10.1021/np400388x",
language = "English",
volume = "76",
pages = "1746--52",
journal = "J NAT PROD",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "9",

}

RIS

TY - JOUR

T1 - Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge

AU - Kolesnikova, Sophia A

AU - Lyakhova, Ekaterina G

AU - Kalinovsky, Anatoly I

AU - Pushilin, Michail A

AU - Afiyatullov, Shamil Sh

AU - Yurchenko, Ekaterina A

AU - Dyshlovoy, Sergey A

AU - Minh, Chau V

AU - Stonik, Valentin A

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Configurations of the triterpene epoxy lactones (1-4) were determined on the basis of NOESY and CD data and calculation of spin coupling constants and confirmed by X-ray crystallographic analysis of compound 2. The isolated triterpenoid 6 was cytotoxic against human leukemia HL-60 cells (IC₅₀ = 9.7 μM).

AB - Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Configurations of the triterpene epoxy lactones (1-4) were determined on the basis of NOESY and CD data and calculation of spin coupling constants and confirmed by X-ray crystallographic analysis of compound 2. The isolated triterpenoid 6 was cytotoxic against human leukemia HL-60 cells (IC₅₀ = 9.7 μM).

KW - Animals

KW - Antineoplastic Agents

KW - Crystallography, X-Ray

KW - Drug Screening Assays, Antitumor

KW - HL-60 Cells

KW - Humans

KW - Lanosterol

KW - Marine Biology

KW - Molecular Structure

KW - Nuclear Magnetic Resonance, Biomolecular

KW - Porifera

KW - Triterpenes

KW - Vietnam

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1021/np400388x

DO - 10.1021/np400388x

M3 - SCORING: Journal article

C2 - 23978047

VL - 76

SP - 1746

EP - 1752

JO - J NAT PROD

JF - J NAT PROD

SN - 0163-3864

IS - 9

ER -