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Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study

Standard

Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study. / Ten Cate, Vincent; Eggebrecht, Lisa; Schulz, Andreas; Panova-Noeva, Marina; Lenz, Michael; Koeck, Thomas; Rapp, Steffen; Arnold, Natalie; Lackner, Karl J; Konstantinides, Stavros; Espinola-Klein, Christine; Münzel, Thomas; Prochaska, Jürgen H; Wild, Philipp S.

in: CHEST, Jahrgang 158, Nr. 1, 07.2020, S. 341-349.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ten Cate, V, Eggebrecht, L, Schulz, A, Panova-Noeva, M, Lenz, M, Koeck, T, Rapp, S, Arnold, N, Lackner, KJ, Konstantinides, S, Espinola-Klein, C, Münzel, T, Prochaska, JH & Wild, PS 2020, 'Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study', CHEST, Jg. 158, Nr. 1, S. 341-349. https://doi.org/10.1016/j.chest.2020.01.055

APA

Ten Cate, V., Eggebrecht, L., Schulz, A., Panova-Noeva, M., Lenz, M., Koeck, T., Rapp, S., Arnold, N., Lackner, K. J., Konstantinides, S., Espinola-Klein, C., Münzel, T., Prochaska, J. H., & Wild, P. S. (2020). Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study. CHEST, 158(1), 341-349. https://doi.org/10.1016/j.chest.2020.01.055

Vancouver

Ten Cate V, Eggebrecht L, Schulz A, Panova-Noeva M, Lenz M, Koeck T et al. Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study. CHEST. 2020 Jul;158(1):341-349. https://doi.org/10.1016/j.chest.2020.01.055

Bibtex

@article{49b4f7ffb2de42eaae473c0800942612,
title = "Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study",
abstract = "BACKGROUND: Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of VTE.RESEARCH QUESTION: We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease.STUDY DESIGN AND METHODS: Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion and imaging-based diagnosis or exclusion of VTE, were analyzed. Patients with PE received whole-leg ultrasonography to assess presence of DVT. Regularized logistic regression identified features that discriminate between isolated PE and other VTE phenotypes at clinical presentation. Survival analyses were performed to evaluate the crude and adjusted 3-year risks of arterial thrombotic disease, recurrent VTE, and death.RESULTS: The sample comprised 510 patients. Isolated PE patients (n = 63) had a distinct clinical profile from patients with other VTE phenotypes (n = 447). COPD, peripheral artery disease, atrial fibrillation, and coronary artery disease were significantly more prevalent among patients with isolated PE. Isolated PE patients had significantly higher risk (incidence rate ratio vs DVT-associated PE, 3.7 (95% CI, 1.3-10.8, P = .009); vs isolated DVT, 4.8 (1.7-14.3, P = .001) of arterial thrombotic events (ie, myocardial infarction, stroke/transient ischemic attack). After adjustment for clinical profile and medication intake, the risk of arterial thrombotic events for patients with isolated PE remained quadruple that of other VTE phenotypes (hazard ratio [HR], 3.8 [1.3-10.9], P = .01).INTERPRETATION: Patients with isolated PE are at higher risk for arterial thrombosis and may require screening for arterial disease and development of novel therapeutic strategies.CLINICAL TRIAL REGISTRATION: NCT02156401.",
keywords = "Aged, Atherosclerosis/diagnosis, Cohort Studies, Female, Humans, Incidence, Logistic Models, Male, Middle Aged, Pulmonary Embolism/complications, Risk Factors, Thrombosis/diagnosis",
author = "{Ten Cate}, Vincent and Lisa Eggebrecht and Andreas Schulz and Marina Panova-Noeva and Michael Lenz and Thomas Koeck and Steffen Rapp and Natalie Arnold and Lackner, {Karl J} and Stavros Konstantinides and Christine Espinola-Klein and Thomas M{\"u}nzel and Prochaska, {J{\"u}rgen H} and Wild, {Philipp S}",
note = "Copyright {\textcopyright} 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = jul,
doi = "10.1016/j.chest.2020.01.055",
language = "English",
volume = "158",
pages = "341--349",
journal = "CHEST",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

RIS

TY - JOUR

T1 - Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease: Results From the VTEval Study

AU - Ten Cate, Vincent

AU - Eggebrecht, Lisa

AU - Schulz, Andreas

AU - Panova-Noeva, Marina

AU - Lenz, Michael

AU - Koeck, Thomas

AU - Rapp, Steffen

AU - Arnold, Natalie

AU - Lackner, Karl J

AU - Konstantinides, Stavros

AU - Espinola-Klein, Christine

AU - Münzel, Thomas

AU - Prochaska, Jürgen H

AU - Wild, Philipp S

N1 - Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of VTE.RESEARCH QUESTION: We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease.STUDY DESIGN AND METHODS: Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion and imaging-based diagnosis or exclusion of VTE, were analyzed. Patients with PE received whole-leg ultrasonography to assess presence of DVT. Regularized logistic regression identified features that discriminate between isolated PE and other VTE phenotypes at clinical presentation. Survival analyses were performed to evaluate the crude and adjusted 3-year risks of arterial thrombotic disease, recurrent VTE, and death.RESULTS: The sample comprised 510 patients. Isolated PE patients (n = 63) had a distinct clinical profile from patients with other VTE phenotypes (n = 447). COPD, peripheral artery disease, atrial fibrillation, and coronary artery disease were significantly more prevalent among patients with isolated PE. Isolated PE patients had significantly higher risk (incidence rate ratio vs DVT-associated PE, 3.7 (95% CI, 1.3-10.8, P = .009); vs isolated DVT, 4.8 (1.7-14.3, P = .001) of arterial thrombotic events (ie, myocardial infarction, stroke/transient ischemic attack). After adjustment for clinical profile and medication intake, the risk of arterial thrombotic events for patients with isolated PE remained quadruple that of other VTE phenotypes (hazard ratio [HR], 3.8 [1.3-10.9], P = .01).INTERPRETATION: Patients with isolated PE are at higher risk for arterial thrombosis and may require screening for arterial disease and development of novel therapeutic strategies.CLINICAL TRIAL REGISTRATION: NCT02156401.

AB - BACKGROUND: Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of VTE.RESEARCH QUESTION: We hypothesized that the presence of isolated PE may signal a chronically elevated risk of arterial thrombotic disease.STUDY DESIGN AND METHODS: Data from the VTEval Study, a prospective cohort study enrolling individuals with clinical suspicion and imaging-based diagnosis or exclusion of VTE, were analyzed. Patients with PE received whole-leg ultrasonography to assess presence of DVT. Regularized logistic regression identified features that discriminate between isolated PE and other VTE phenotypes at clinical presentation. Survival analyses were performed to evaluate the crude and adjusted 3-year risks of arterial thrombotic disease, recurrent VTE, and death.RESULTS: The sample comprised 510 patients. Isolated PE patients (n = 63) had a distinct clinical profile from patients with other VTE phenotypes (n = 447). COPD, peripheral artery disease, atrial fibrillation, and coronary artery disease were significantly more prevalent among patients with isolated PE. Isolated PE patients had significantly higher risk (incidence rate ratio vs DVT-associated PE, 3.7 (95% CI, 1.3-10.8, P = .009); vs isolated DVT, 4.8 (1.7-14.3, P = .001) of arterial thrombotic events (ie, myocardial infarction, stroke/transient ischemic attack). After adjustment for clinical profile and medication intake, the risk of arterial thrombotic events for patients with isolated PE remained quadruple that of other VTE phenotypes (hazard ratio [HR], 3.8 [1.3-10.9], P = .01).INTERPRETATION: Patients with isolated PE are at higher risk for arterial thrombosis and may require screening for arterial disease and development of novel therapeutic strategies.CLINICAL TRIAL REGISTRATION: NCT02156401.

KW - Aged

KW - Atherosclerosis/diagnosis

KW - Cohort Studies

KW - Female

KW - Humans

KW - Incidence

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Pulmonary Embolism/complications

KW - Risk Factors

KW - Thrombosis/diagnosis

U2 - 10.1016/j.chest.2020.01.055

DO - 10.1016/j.chest.2020.01.055

M3 - SCORING: Journal article

C2 - 32217063

VL - 158

SP - 341

EP - 349

JO - CHEST

JF - CHEST

SN - 0012-3692

IS - 1

ER -