Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia.

  • Thorsten Annecke
  • Markus Rehm
  • Dirk Bruegger
  • Jens Kubitz
  • Gregor I Kemming
  • Mechthild Stoekelhuber
  • Bernhard F Becker
  • Peter F Conzen

Abstract

Vascular leakage after ischemia-reperfusion (IR) is largely attributed to the destruction of the endothelial barrier and its associated negatively charged glycocalyx. In vitro, sevoflurane attenuates these changes. Therefore, we compared sevoflurane with propofol with regard to the protection of the glycocalyx and the release of negatively charged substances in vivo.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer3
ISSN0894-1939
StatusVeröffentlicht - 2012
pubmed 22583012