Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

TY - JOUR

T1 - Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers

AU - Fjell, Anders M

AU - Sørensen, Øystein

AU - Wang, Yunpeng

AU - Amlien, Inge K

AU - Baaré, William F C

AU - Bartrés-Faz, David

AU - Boraxbekk, Carl-Johan

AU - Brandmaier, Andreas M

AU - Demuth, Ilja

AU - Drevon, Christian A

AU - Ebmeier, Klaus P

AU - Ghisletta, Paolo

AU - Kievit, Rogier

AU - Kühn, Simone

AU - Madsen, Kathrine Skak

AU - Nyberg, Lars

AU - Solé-Padullés, Cristina

AU - Vidal-Piñeiro, Didac

AU - Wagner, Gerd

AU - Watne, Leiv Otto

AU - Walhovd, Kristine B

N1 - Copyright © 2023 the authors.

PY - 2023/7/12

Y1 - 2023/7/12

N2 - Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep need and are more resistant to negative effects of sleep loss. We investigated this using a cross-sectional and longitudinal sample of 47,029 participants of both sexes (20-89 years) from the Lifebrain consortium, Human Connectome project (HCP) and UK Biobank (UKB), with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. A total of 740 participants who reported to sleep <6 h did not experience daytime sleepiness or sleep problems/disturbances interfering with falling or staying asleep. These short sleepers showed significantly larger regional brain volumes than both short sleepers with daytime sleepiness and sleep problems (n = 1742) and participants sleeping the recommended 7-8 h (n = 3886). However, both groups of short sleepers showed slightly lower general cognitive function (GCA), 0.16 and 0.19 SDs, respectively. Analyses using accelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income, and education. The results suggest that some people can cope with less sleep without obvious negative associations with brain morphometry and that sleepiness and sleep problems may be more related to brain structural differences than duration. However, the slightly lower performance on tests of general cognitive abilities warrants closer examination in natural settings.SIGNIFICANCE STATEMENT Short habitual sleep is prevalent, with unknown consequences for brain health and cognitive performance. Here, we show that daytime sleepiness and sleep problems are more strongly related to regional brain volumes than sleep duration. However, participants sleeping ≤6 h had slightly lower scores on tests of general cognitive function (GCA). This indicates that sleep need is individual and that sleep duration per se is very weakly if at all related brain health, while daytime sleepiness and sleep problems may show somewhat stronger associations. The association between habitual short sleep and lower scores on tests of general cognitive abilities must be further scrutinized in natural settings.

AB - Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep need and are more resistant to negative effects of sleep loss. We investigated this using a cross-sectional and longitudinal sample of 47,029 participants of both sexes (20-89 years) from the Lifebrain consortium, Human Connectome project (HCP) and UK Biobank (UKB), with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. A total of 740 participants who reported to sleep <6 h did not experience daytime sleepiness or sleep problems/disturbances interfering with falling or staying asleep. These short sleepers showed significantly larger regional brain volumes than both short sleepers with daytime sleepiness and sleep problems (n = 1742) and participants sleeping the recommended 7-8 h (n = 3886). However, both groups of short sleepers showed slightly lower general cognitive function (GCA), 0.16 and 0.19 SDs, respectively. Analyses using accelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income, and education. The results suggest that some people can cope with less sleep without obvious negative associations with brain morphometry and that sleepiness and sleep problems may be more related to brain structural differences than duration. However, the slightly lower performance on tests of general cognitive abilities warrants closer examination in natural settings.SIGNIFICANCE STATEMENT Short habitual sleep is prevalent, with unknown consequences for brain health and cognitive performance. Here, we show that daytime sleepiness and sleep problems are more strongly related to regional brain volumes than sleep duration. However, participants sleeping ≤6 h had slightly lower scores on tests of general cognitive function (GCA). This indicates that sleep need is individual and that sleep duration per se is very weakly if at all related brain health, while daytime sleepiness and sleep problems may show somewhat stronger associations. The association between habitual short sleep and lower scores on tests of general cognitive abilities must be further scrutinized in natural settings.

KW - Male

KW - Female

KW - Humans

KW - Cross-Sectional Studies

KW - Brain/diagnostic imaging

KW - Sleep

KW - Sleep Deprivation/diagnostic imaging

KW - Sleep Wake Disorders/complications

KW - Cognition

KW - Disorders of Excessive Somnolence/complications

U2 - 10.1523/JNEUROSCI.2330-22.2023

DO - 10.1523/JNEUROSCI.2330-22.2023

M3 - SCORING: Journal article

C2 - 37365003

VL - 43

SP - 5241

EP - 5250

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 28

ER -