PortalPublikationenIs APOE ε4 associated with cognitive performance in early MS...

Is APOE ε4 associated with cognitive performance in early MS?

Standard

Is APOE ε4 associated with cognitive performance in early MS? / Engel, Sinah; Graetz, Christiane; Salmen, Anke; Muthuraman, Muthuraman; Toenges, Gerrit; Ambrosius, Björn; Bayas, Antonios; Berthele, Achim; Heesen, Christoph; Klotz, Luisa; Kümpfel, Tania; Linker, Ralf A; Meuth, Sven G; Paul, Friedemann; Stangel, Martin; Tackenberg, Björn; Then Bergh, Florian; Tumani, Hayrettin; Weber, Frank; Wildemann, Brigitte; Zettl, Uwe K; Antony, Gisela; Bittner, Stefan; Groppa, Sergiu; Hemmer, Bernhard; Wiendl, Heinz; Gold, Ralf; Zipp, Frauke; Lill, Christina M; Luessi, Felix; German Competence Network of Multiple Sclerosis.

in: NEUROL-NEUROIMMUNOL, Jahrgang 7, Nr. 4, 07.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Engel, S, Graetz, C, Salmen, A, Muthuraman, M, Toenges, G, Ambrosius, B, Bayas, A, Berthele, A, Heesen, C, Klotz, L, Kümpfel, T, Linker, RA, Meuth, SG, Paul, F, Stangel, M, Tackenberg, B, Then Bergh, F, Tumani, H, Weber, F, Wildemann, B, Zettl, UK, Antony, G, Bittner, S, Groppa, S, Hemmer, B, Wiendl, H, Gold, R, Zipp, F, Lill, CM, Luessi, F & German Competence Network of Multiple Sclerosis 2020, 'Is APOE ε4 associated with cognitive performance in early MS?', NEUROL-NEUROIMMUNOL, Jg. 7, Nr. 4. https://doi.org/10.1212/NXI.0000000000000728

APA

Engel, S., Graetz, C., Salmen, A., Muthuraman, M., Toenges, G., Ambrosius, B., Bayas, A., Berthele, A., Heesen, C., Klotz, L., Kümpfel, T., Linker, R. A., Meuth, S. G., Paul, F., Stangel, M., Tackenberg, B., Then Bergh, F., Tumani, H., Weber, F., ... German Competence Network of Multiple Sclerosis (2020). Is APOE ε4 associated with cognitive performance in early MS? NEUROL-NEUROIMMUNOL, 7(4). https://doi.org/10.1212/NXI.0000000000000728

Vancouver

Engel S, Graetz C, Salmen A, Muthuraman M, Toenges G, Ambrosius B et al. Is APOE ε4 associated with cognitive performance in early MS? NEUROL-NEUROIMMUNOL. 2020 Jul;7(4). https://doi.org/10.1212/NXI.0000000000000728

Bibtex

@article{a7a9a063499244cd8c32b14eb5d67430,
title = "Is APOE ε4 associated with cognitive performance in early MS?",
abstract = "OBJECTIVE: To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).METHODS: This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of the APOE carrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors.RESULTS: APOE ε4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed for APOE ε4 heterozygosity or APOE ε2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed for APOE carrier status.CONCLUSION: Along with parameters of a higher disease burden, APOE ε4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.",
author = "Sinah Engel and Christiane Graetz and Anke Salmen and Muthuraman Muthuraman and Gerrit Toenges and Bj{\"o}rn Ambrosius and Antonios Bayas and Achim Berthele and Christoph Heesen and Luisa Klotz and Tania K{\"u}mpfel and Linker, {Ralf A} and Meuth, {Sven G} and Friedemann Paul and Martin Stangel and Bj{\"o}rn Tackenberg and {Then Bergh}, Florian and Hayrettin Tumani and Frank Weber and Brigitte Wildemann and Zettl, {Uwe K} and Gisela Antony and Stefan Bittner and Sergiu Groppa and Bernhard Hemmer and Heinz Wiendl and Ralf Gold and Frauke Zipp and Lill, {Christina M} and Felix Luessi and {German Competence Network of Multiple Sclerosis}",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.",
year = "2020",
month = jul,
doi = "10.1212/NXI.0000000000000728",
language = "English",
volume = "7",
journal = "NEUROL-NEUROIMMUNOL",
issn = "2332-7812",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Is APOE ε4 associated with cognitive performance in early MS?

AU - Engel, Sinah

AU - Graetz, Christiane

AU - Salmen, Anke

AU - Muthuraman, Muthuraman

AU - Toenges, Gerrit

AU - Ambrosius, Björn

AU - Bayas, Antonios

AU - Berthele, Achim

AU - Heesen, Christoph

AU - Klotz, Luisa

AU - Kümpfel, Tania

AU - Linker, Ralf A

AU - Meuth, Sven G

AU - Paul, Friedemann

AU - Stangel, Martin

AU - Tackenberg, Björn

AU - Then Bergh, Florian

AU - Tumani, Hayrettin

AU - Weber, Frank

AU - Wildemann, Brigitte

AU - Zettl, Uwe K

AU - Antony, Gisela

AU - Bittner, Stefan

AU - Groppa, Sergiu

AU - Hemmer, Bernhard

AU - Wiendl, Heinz

AU - Gold, Ralf

AU - Zipp, Frauke

AU - Lill, Christina M

AU - Luessi, Felix

AU - German Competence Network of Multiple Sclerosis

N1 - Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

PY - 2020/7

Y1 - 2020/7

N2 - OBJECTIVE: To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).METHODS: This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of the APOE carrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors.RESULTS: APOE ε4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed for APOE ε4 heterozygosity or APOE ε2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed for APOE carrier status.CONCLUSION: Along with parameters of a higher disease burden, APOE ε4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.

AB - OBJECTIVE: To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).METHODS: This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of the APOE carrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors.RESULTS: APOE ε4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed for APOE ε4 heterozygosity or APOE ε2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed for APOE carrier status.CONCLUSION: Along with parameters of a higher disease burden, APOE ε4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.

U2 - 10.1212/NXI.0000000000000728

DO - 10.1212/NXI.0000000000000728

M3 - SCORING: Journal article

C2 - 32358224

VL - 7

JO - NEUROL-NEUROIMMUNOL

JF - NEUROL-NEUROIMMUNOL

SN - 2332-7812

IS - 4

ER -