Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results?
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Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results? / Baghi, Mehran; Mack, Martin G; Wagenblast, Jens; Hambek, Markus; Rieger, Jörg; Bisdas, Sotirios; Gstoettner, Wolfgang; Engels, Knut; Vogl, Thomas; Knecht, Rainald.
in: ANTICANCER RES, Jahrgang 27, Nr. 5, 5, 2007, S. 3571-3575.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Iron oxide particle-enhanced magnetic resonance imaging for detection of benign lymph nodes in the head and neck: how reliable are the results?
AU - Baghi, Mehran
AU - Mack, Martin G
AU - Wagenblast, Jens
AU - Hambek, Markus
AU - Rieger, Jörg
AU - Bisdas, Sotirios
AU - Gstoettner, Wolfgang
AU - Engels, Knut
AU - Vogl, Thomas
AU - Knecht, Rainald
PY - 2007
Y1 - 2007
N2 - AIM: To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard. PATIENTS AND METHODS: Seventeen patients with a histologically proven squamous cell cancer of the head and neck (SCCHN) and different N-stages underwent a non-enhanced and a USPIO-enhanced MRI examination. Signal intensity (SI) was measured in a region of interest evaluation. Pathohistological examination was used as a reference. RESULTS: On a patient basis, USPIO-enhanced MRI showed a higher specificity and diagnostic accuracy (94%) compared with non-enhanced MRI (53%). One patient showed a lymph node of 6 mm in the short axial diameter which was suggested as being metastatic in Sinerem-enhanced MRI according to the enhancement pattern of Sinerem. This patient was staged as N1 with Sinerem-enhanced MRI. The histopathological examination did not confirm the Sinerem-enhanced MRI result. CONCLUSION: The high values for the specifity and diagnostic accuracy of Sinerem- enhanced MRI justifies further investigations with this contrast agent. USPIO-enhanced MRI could be advantageous in avoiding surgical overtreatment.
AB - AIM: To evaluate the accuracy of ultrasmall paramagnetic iron oxide (USPIO: Sinerem)-enhanced MRI in patients with head and neck cancer and enlarged lymph nodes compared with current staging examinations using histology as a gold standard. PATIENTS AND METHODS: Seventeen patients with a histologically proven squamous cell cancer of the head and neck (SCCHN) and different N-stages underwent a non-enhanced and a USPIO-enhanced MRI examination. Signal intensity (SI) was measured in a region of interest evaluation. Pathohistological examination was used as a reference. RESULTS: On a patient basis, USPIO-enhanced MRI showed a higher specificity and diagnostic accuracy (94%) compared with non-enhanced MRI (53%). One patient showed a lymph node of 6 mm in the short axial diameter which was suggested as being metastatic in Sinerem-enhanced MRI according to the enhancement pattern of Sinerem. This patient was staged as N1 with Sinerem-enhanced MRI. The histopathological examination did not confirm the Sinerem-enhanced MRI result. CONCLUSION: The high values for the specifity and diagnostic accuracy of Sinerem- enhanced MRI justifies further investigations with this contrast agent. USPIO-enhanced MRI could be advantageous in avoiding surgical overtreatment.
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 3571
EP - 3575
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 5
M1 - 5
ER -
