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Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study

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Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study. / Schrage, Benedikt; Rübsamen, Nicole; Schulz, Andreas; Münzel, Thomas; Pfeiffer, Norbert; Wild, Philipp S; Beutel, Manfred; Schmidtmann, Irene; Lott, Rosemarie; Blankenberg, Stefan; Zeller, Tanja; Lackner, Karl J; Karakas, Mahir.

in: CLIN RES CARDIOL, Jahrgang 109, Nr. 11, 11.2020, S. 1352-1357.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schrage, B, Rübsamen, N, Schulz, A, Münzel, T, Pfeiffer, N, Wild, PS, Beutel, M, Schmidtmann, I, Lott, R, Blankenberg, S, Zeller, T, Lackner, KJ & Karakas, M 2020, 'Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study', CLIN RES CARDIOL, Jg. 109, Nr. 11, S. 1352-1357. https://doi.org/10.1007/s00392-020-01631-y

APA

Schrage, B., Rübsamen, N., Schulz, A., Münzel, T., Pfeiffer, N., Wild, P. S., Beutel, M., Schmidtmann, I., Lott, R., Blankenberg, S., Zeller, T., Lackner, K. J., & Karakas, M. (2020). Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study. CLIN RES CARDIOL, 109(11), 1352-1357. https://doi.org/10.1007/s00392-020-01631-y

Vancouver

Schrage B, Rübsamen N, Schulz A, Münzel T, Pfeiffer N, Wild PS et al. Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study. CLIN RES CARDIOL. 2020 Nov;109(11):1352-1357. https://doi.org/10.1007/s00392-020-01631-y

Bibtex

@article{5e555499528d42fa9e03097031983898,
title = "Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study",
abstract = "BACKGROUND: Iron deficiency is now accepted as an independent entity beyond anemia. Recently, a new functional definition of iron deficiency was proposed and proved strong efficacy in randomized cardiovascular clinical trials of intravenous iron supplementation. Here, we characterize the impact of iron deficiency on all-cause mortality in the non-anemic general population based on two distinct definitions.METHODS: The Gutenberg Health Study is a population-based, prospective, single-center cohort study. The 5000 individuals between 35 and 74 years underwent baseline and a planned follow-up visit at year 5. Tested definitions of iron deficiency were (1) functional iron deficiency-ferritin levels below 100 µg/l, or ferritin levels between 100 and 299 µg/l and transferrin saturation below 20%, and (2) absolute iron deficiency-ferritin below 30 µg/l.RESULTS: At baseline, a total of 54.5% of participants showed functional iron deficiency at a mean hemoglobin of 14.3 g/dl; while, the rate of absolute iron deficiency was 11.8%, at a mean hemoglobin level of 13.4 g/dl. At year 5, proportion of newly diagnosed subjects was 18.5% and 4.8%, respectively. Rate of all-cause mortality was 7.2% (n = 361); while, median follow-up was 10.1 years. After adjustment for hemoglobin and major cardiovascular risk factors, the hazard ratio with 95% confidence interval of the association of iron deficiency with mortality was 1.3 (1.0-1.6; p = 0.023) for the functional definition, and 1.9 (1.3-2.8; p = 0.002) for absolute iron deficiency.CONCLUSIONS: Iron deficiency is very common in the apparently healthy general population and independently associated with all-cause mortality in the mid to long term.",
keywords = "Adult, Aged, Anemia, Iron-Deficiency/blood, Biomarkers/blood, Cause of Death/trends, Female, Germany/epidemiology, Hemoglobins/metabolism, Humans, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Registries, Survival Rate/trends",
author = "Benedikt Schrage and Nicole R{\"u}bsamen and Andreas Schulz and Thomas M{\"u}nzel and Norbert Pfeiffer and Wild, {Philipp S} and Manfred Beutel and Irene Schmidtmann and Rosemarie Lott and Stefan Blankenberg and Tanja Zeller and Lackner, {Karl J} and Mahir Karakas",
year = "2020",
month = nov,
doi = "10.1007/s00392-020-01631-y",
language = "English",
volume = "109",
pages = "1352--1357",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "11",

}

RIS

TY - JOUR

T1 - Iron deficiency is a common disorder in general population and independently predicts all-cause mortality: results from the Gutenberg Health Study

AU - Schrage, Benedikt

AU - Rübsamen, Nicole

AU - Schulz, Andreas

AU - Münzel, Thomas

AU - Pfeiffer, Norbert

AU - Wild, Philipp S

AU - Beutel, Manfred

AU - Schmidtmann, Irene

AU - Lott, Rosemarie

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Lackner, Karl J

AU - Karakas, Mahir

PY - 2020/11

Y1 - 2020/11

N2 - BACKGROUND: Iron deficiency is now accepted as an independent entity beyond anemia. Recently, a new functional definition of iron deficiency was proposed and proved strong efficacy in randomized cardiovascular clinical trials of intravenous iron supplementation. Here, we characterize the impact of iron deficiency on all-cause mortality in the non-anemic general population based on two distinct definitions.METHODS: The Gutenberg Health Study is a population-based, prospective, single-center cohort study. The 5000 individuals between 35 and 74 years underwent baseline and a planned follow-up visit at year 5. Tested definitions of iron deficiency were (1) functional iron deficiency-ferritin levels below 100 µg/l, or ferritin levels between 100 and 299 µg/l and transferrin saturation below 20%, and (2) absolute iron deficiency-ferritin below 30 µg/l.RESULTS: At baseline, a total of 54.5% of participants showed functional iron deficiency at a mean hemoglobin of 14.3 g/dl; while, the rate of absolute iron deficiency was 11.8%, at a mean hemoglobin level of 13.4 g/dl. At year 5, proportion of newly diagnosed subjects was 18.5% and 4.8%, respectively. Rate of all-cause mortality was 7.2% (n = 361); while, median follow-up was 10.1 years. After adjustment for hemoglobin and major cardiovascular risk factors, the hazard ratio with 95% confidence interval of the association of iron deficiency with mortality was 1.3 (1.0-1.6; p = 0.023) for the functional definition, and 1.9 (1.3-2.8; p = 0.002) for absolute iron deficiency.CONCLUSIONS: Iron deficiency is very common in the apparently healthy general population and independently associated with all-cause mortality in the mid to long term.

AB - BACKGROUND: Iron deficiency is now accepted as an independent entity beyond anemia. Recently, a new functional definition of iron deficiency was proposed and proved strong efficacy in randomized cardiovascular clinical trials of intravenous iron supplementation. Here, we characterize the impact of iron deficiency on all-cause mortality in the non-anemic general population based on two distinct definitions.METHODS: The Gutenberg Health Study is a population-based, prospective, single-center cohort study. The 5000 individuals between 35 and 74 years underwent baseline and a planned follow-up visit at year 5. Tested definitions of iron deficiency were (1) functional iron deficiency-ferritin levels below 100 µg/l, or ferritin levels between 100 and 299 µg/l and transferrin saturation below 20%, and (2) absolute iron deficiency-ferritin below 30 µg/l.RESULTS: At baseline, a total of 54.5% of participants showed functional iron deficiency at a mean hemoglobin of 14.3 g/dl; while, the rate of absolute iron deficiency was 11.8%, at a mean hemoglobin level of 13.4 g/dl. At year 5, proportion of newly diagnosed subjects was 18.5% and 4.8%, respectively. Rate of all-cause mortality was 7.2% (n = 361); while, median follow-up was 10.1 years. After adjustment for hemoglobin and major cardiovascular risk factors, the hazard ratio with 95% confidence interval of the association of iron deficiency with mortality was 1.3 (1.0-1.6; p = 0.023) for the functional definition, and 1.9 (1.3-2.8; p = 0.002) for absolute iron deficiency.CONCLUSIONS: Iron deficiency is very common in the apparently healthy general population and independently associated with all-cause mortality in the mid to long term.

KW - Adult

KW - Aged

KW - Anemia, Iron-Deficiency/blood

KW - Biomarkers/blood

KW - Cause of Death/trends

KW - Female

KW - Germany/epidemiology

KW - Hemoglobins/metabolism

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Prognosis

KW - Prospective Studies

KW - Registries

KW - Survival Rate/trends

U2 - 10.1007/s00392-020-01631-y

DO - 10.1007/s00392-020-01631-y

M3 - SCORING: Journal article

C2 - 32215702

VL - 109

SP - 1352

EP - 1357

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 11

ER -