Ionizing radiation biomarkers for potential use in epidemiological studies
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Ionizing radiation biomarkers for potential use in epidemiological studies. / Pernot, Eileen; Hall, Janet; Baatout, Sarah; Benotmane, Mohammed Abderrafi; Blanchardon, Eric; Bouffler, Simon; El Saghire, Houssein; Gomolka, Maria; Guertler, Anne; Harms-Ringdahl, Mats; Jeggo, Penny; Kreuzer, Michaela; Laurier, Dominique; Lindholm, Carita; Mkacher, Radhia; Quintens, Roel; Rothkamm, Kai; Sabatier, Laure; Tapio, Soile; de Vathaire, Florent; Cardis, Elisabeth.
in: MUTAT RES-FUND MOL M, Jahrgang 751, Nr. 2, 09.06.2012, S. 258-86.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Ionizing radiation biomarkers for potential use in epidemiological studies
AU - Pernot, Eileen
AU - Hall, Janet
AU - Baatout, Sarah
AU - Benotmane, Mohammed Abderrafi
AU - Blanchardon, Eric
AU - Bouffler, Simon
AU - El Saghire, Houssein
AU - Gomolka, Maria
AU - Guertler, Anne
AU - Harms-Ringdahl, Mats
AU - Jeggo, Penny
AU - Kreuzer, Michaela
AU - Laurier, Dominique
AU - Lindholm, Carita
AU - Mkacher, Radhia
AU - Quintens, Roel
AU - Rothkamm, Kai
AU - Sabatier, Laure
AU - Tapio, Soile
AU - de Vathaire, Florent
AU - Cardis, Elisabeth
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2012/6/9
Y1 - 2012/6/9
N2 - Ionizing radiation is a known human carcinogen that can induce a variety of biological effects depending on the physical nature, duration, doses and dose-rates of exposure. However, the magnitude of health risks at low doses and dose-rates (below 100mSv and/or 0.1mSvmin(-1)) remains controversial due to a lack of direct human evidence. It is anticipated that significant insights will emerge from the integration of epidemiological and biological research, made possible by molecular epidemiology studies incorporating biomarkers and bioassays. A number of these have been used to investigate exposure, effects and susceptibility to ionizing radiation, albeit often at higher doses and dose rates, with each reflecting time-limited cellular or physiological alterations. This review summarises the multidisciplinary work undertaken in the framework of the European project DoReMi (Low Dose Research towards Multidisciplinary Integration) to identify the most appropriate biomarkers for use in population studies. In addition to logistical and ethical considerations for conducting large-scale epidemiological studies, we discuss the relevance of their use for assessing the effects of low dose ionizing radiation exposure at the cellular and physiological level. We also propose a temporal classification of biomarkers that may be relevant for molecular epidemiology studies which need to take into account the time elapsed since exposure. Finally, the integration of biology with epidemiology requires careful planning and enhanced discussions between the epidemiology, biology and dosimetry communities in order to determine the most important questions to be addressed in light of pragmatic considerations including the appropriate population to be investigated (occupationally, environmentally or medically exposed), and study design. The consideration of the logistics of biological sample collection, processing and storing and the choice of biomarker or bioassay, as well as awareness of potential confounding factors, are also essential.
AB - Ionizing radiation is a known human carcinogen that can induce a variety of biological effects depending on the physical nature, duration, doses and dose-rates of exposure. However, the magnitude of health risks at low doses and dose-rates (below 100mSv and/or 0.1mSvmin(-1)) remains controversial due to a lack of direct human evidence. It is anticipated that significant insights will emerge from the integration of epidemiological and biological research, made possible by molecular epidemiology studies incorporating biomarkers and bioassays. A number of these have been used to investigate exposure, effects and susceptibility to ionizing radiation, albeit often at higher doses and dose rates, with each reflecting time-limited cellular or physiological alterations. This review summarises the multidisciplinary work undertaken in the framework of the European project DoReMi (Low Dose Research towards Multidisciplinary Integration) to identify the most appropriate biomarkers for use in population studies. In addition to logistical and ethical considerations for conducting large-scale epidemiological studies, we discuss the relevance of their use for assessing the effects of low dose ionizing radiation exposure at the cellular and physiological level. We also propose a temporal classification of biomarkers that may be relevant for molecular epidemiology studies which need to take into account the time elapsed since exposure. Finally, the integration of biology with epidemiology requires careful planning and enhanced discussions between the epidemiology, biology and dosimetry communities in order to determine the most important questions to be addressed in light of pragmatic considerations including the appropriate population to be investigated (occupationally, environmentally or medically exposed), and study design. The consideration of the logistics of biological sample collection, processing and storing and the choice of biomarker or bioassay, as well as awareness of potential confounding factors, are also essential.
KW - Biomarkers
KW - Cells, Cultured
KW - Chromosome Aberrations
KW - DNA Damage
KW - Epidemiologic Studies
KW - Epigenesis, Genetic
KW - Humans
KW - Metabolomics
KW - Molecular Epidemiology
KW - Radiation, Ionizing
KW - Reactive Oxygen Species
U2 - 10.1016/j.mrrev.2012.05.003
DO - 10.1016/j.mrrev.2012.05.003
M3 - SCORING: Review article
C2 - 22677531
VL - 751
SP - 258
EP - 286
IS - 2
ER -
