Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.

Nikolaus Möckelmann; Witigo von Schönfels; Stephan Buch; Oliver von Kampen; Bence Sipos; Jan Hendrik Egberts; Philip Rosenstiel; Andre Franke; Mario Brosch; Sebastian Hinz; Christian Röder; Holger Kalthoff; Ulrich R Fölsch; Michael Krawczak; Stefan Schreiber; Clemens Dieter Bröring; Jürgen Tepel; Clemens Schafmayer; Jochen Hampe

Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.

Standard

Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. / Möckelmann, Nikolaus; von Schönfels, Witigo; Buch, Stephan; von Kampen, Oliver; Sipos, Bence; Egberts, Jan Hendrik; Rosenstiel, Philip; Franke, Andre; Brosch, Mario; Hinz, Sebastian; Röder, Christian; Kalthoff, Holger; Fölsch, Ulrich R; Krawczak, Michael; Schreiber, Stefan; Bröring, Clemens Dieter; Tepel, Jürgen; Schafmayer, Clemens; Hampe, Jochen.

in: BMC GASTROENTEROL, Jahrgang 9, 2009, S. 79.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Möckelmann, N, von Schönfels, W, Buch, S, von Kampen, O, Sipos, B, Egberts, JH, Rosenstiel, P, Franke, A, Brosch, M, Hinz, S, Röder, C, Kalthoff, H, Fölsch, UR, Krawczak, M, Schreiber, S, Bröring, CD, Tepel, J, Schafmayer, C & Hampe, J 2009, 'Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.', BMC GASTROENTEROL, Jg. 9, S. 79. <http://www.ncbi.nlm.nih.gov/pubmed/19843337?dopt=Citation>

APA

Möckelmann, N., von Schönfels, W., Buch, S., von Kampen, O., Sipos, B., Egberts, J. H., Rosenstiel, P., Franke, A., Brosch, M., Hinz, S., Röder, C., Kalthoff, H., Fölsch, U. R., Krawczak, M., Schreiber, S., Bröring, C. D., Tepel, J., Schafmayer, C., & Hampe, J. (2009). Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC GASTROENTEROL, 9, 79. http://www.ncbi.nlm.nih.gov/pubmed/19843337?dopt=Citation

Vancouver

Möckelmann N, von Schönfels W, Buch S, von Kampen O, Sipos B, Egberts JH et al. Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC GASTROENTEROL. 2009;9:79.

Bibtex

@article{7cd455314038450d9aade72ef657947e,

title = "Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.",

abstract = "BACKGROUND: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated the impact of germline variation at the CARD4, CARD8 and CARD15 loci on the risk for sporadic CRC, using a large patient sample from Northern Germany. METHODS: A total of 1044 patients who had been operated with sporadic colorectal carcinoma (median age at diagnosis: 59 years) were recruited and compared to 724 sex-matched, population-based control individuals (median age: 68 years). Genetic investigation was carried out following both a coding SNP and haplotype tagging approach. Subgroup analyses for N = 143 patients with early manifestation of CRC (",

keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Genetic Predisposition to Disease, Retrospective Studies, Mutation, Apoptosis, CARD Signaling Adaptor Proteins genetics, Colorectal Neoplasms genetics, DNA, Neoplasm genetics, Immunity, Innate genetics, Neoplasm Proteins genetics, Nod1 Signaling Adaptor Protein genetics, Nod2 Signaling Adaptor Protein genetics, Phenotype, Reverse Transcriptase Polymerase Chain Reaction, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Young Adult, Genetic Predisposition to Disease, Retrospective Studies, Mutation, Apoptosis, CARD Signaling Adaptor Proteins genetics, Colorectal Neoplasms genetics, DNA, Neoplasm genetics, Immunity, Innate genetics, Neoplasm Proteins genetics, Nod1 Signaling Adaptor Protein genetics, Nod2 Signaling Adaptor Protein genetics, Phenotype, Reverse Transcriptase Polymerase Chain Reaction",

author = "Nikolaus M{\"o}ckelmann and {von Sch{\"o}nfels}, Witigo and Stephan Buch and {von Kampen}, Oliver and Bence Sipos and Egberts, {Jan Hendrik} and Philip Rosenstiel and Andre Franke and Mario Brosch and Sebastian Hinz and Christian R{\"o}der and Holger Kalthoff and F{\"o}lsch, {Ulrich R} and Michael Krawczak and Stefan Schreiber and Br{\"o}ring, {Clemens Dieter} and J{\"u}rgen Tepel and Clemens Schafmayer and Jochen Hampe",

year = "2009",

language = "Deutsch",

volume = "9",

pages = "79",

journal = "BMC GASTROENTEROL",

issn = "1471-230X",

publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.

AU - Möckelmann, Nikolaus

AU - von Schönfels, Witigo

AU - Buch, Stephan

AU - von Kampen, Oliver

AU - Sipos, Bence

AU - Egberts, Jan Hendrik

AU - Rosenstiel, Philip

AU - Franke, Andre

AU - Brosch, Mario

AU - Hinz, Sebastian

AU - Röder, Christian

AU - Kalthoff, Holger

AU - Fölsch, Ulrich R

AU - Krawczak, Michael

AU - Schreiber, Stefan

AU - Bröring, Clemens Dieter

AU - Tepel, Jürgen

AU - Schafmayer, Clemens

AU - Hampe, Jochen

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated the impact of germline variation at the CARD4, CARD8 and CARD15 loci on the risk for sporadic CRC, using a large patient sample from Northern Germany. METHODS: A total of 1044 patients who had been operated with sporadic colorectal carcinoma (median age at diagnosis: 59 years) were recruited and compared to 724 sex-matched, population-based control individuals (median age: 68 years). Genetic investigation was carried out following both a coding SNP and haplotype tagging approach. Subgroup analyses for N = 143 patients with early manifestation of CRC (

AB - BACKGROUND: Variation in genes involved in the innate immune response may play a role in the predisposition to colorectal cancer (CRC). Several polymorphisms of the CARD15 gene (caspase activating recruitment domain, member 15) have been reported to be associated with an increased susceptibility to Crohn disease. Since the CARD15 gene product and other CARD proteins function in innate immunity, we investigated the impact of germline variation at the CARD4, CARD8 and CARD15 loci on the risk for sporadic CRC, using a large patient sample from Northern Germany. METHODS: A total of 1044 patients who had been operated with sporadic colorectal carcinoma (median age at diagnosis: 59 years) were recruited and compared to 724 sex-matched, population-based control individuals (median age: 68 years). Genetic investigation was carried out following both a coding SNP and haplotype tagging approach. Subgroup analyses for N = 143 patients with early manifestation of CRC (

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Young Adult

KW - Genetic Predisposition to Disease

KW - Retrospective Studies

KW - Mutation

KW - Apoptosis

KW - CARD Signaling Adaptor Proteins genetics

KW - Colorectal Neoplasms genetics

KW - DNA, Neoplasm genetics

KW - Immunity, Innate genetics

KW - Neoplasm Proteins genetics

KW - Nod1 Signaling Adaptor Protein genetics

KW - Nod2 Signaling Adaptor Protein genetics

KW - Phenotype

KW - Reverse Transcriptase Polymerase Chain Reaction