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Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer

Standard

Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer. / Brocks, David; Assenov, Yassen; Minner, Sarah; Bogatyrova, Olga; Simon, Ronald; Koop, Christina; Oakes, Christopher; Zucknick, Manuela; Lipka, Daniel Bernhard; Weischenfeldt, Joachim; Feuerbach, Lars; Cowper-Sal Lari, Richard; Lupien, Mathieu; Brors, Benedikt; Korbel, Jan; Schlomm, Thorsten; Tanay, Amos; Sauter, Guido; Gerhäuser, Clarissa; Plass, Christoph; ICGC Early Onset Prostate Cancer Project.

in: CELL REP, Jahrgang 8, Nr. 3, 07.08.2014, S. 798-806.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Brocks, D, Assenov, Y, Minner, S, Bogatyrova, O, Simon, R, Koop, C, Oakes, C, Zucknick, M, Lipka, DB, Weischenfeldt, J, Feuerbach, L, Cowper-Sal Lari, R, Lupien, M, Brors, B, Korbel, J, Schlomm, T, Tanay, A, Sauter, G, Gerhäuser, C, Plass, C & ICGC Early Onset Prostate Cancer Project 2014, 'Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer', CELL REP, Jg. 8, Nr. 3, S. 798-806. https://doi.org/10.1016/j.celrep.2014.06.053

APA

Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhäuser, C., ... ICGC Early Onset Prostate Cancer Project (2014). Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer. CELL REP, 8(3), 798-806. https://doi.org/10.1016/j.celrep.2014.06.053

Vancouver

Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C et al. Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer. CELL REP. 2014 Aug 7;8(3):798-806. https://doi.org/10.1016/j.celrep.2014.06.053

Bibtex

@article{d4b46d416dae45aca57d6bcd636c5e10,
title = "Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer",
abstract = "Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we show that the prostate intratumor heterogeneity in DNA methylation and copy-number patterns can be explained by a unified evolutionary process. By assaying multiple topographically distinct tumor sites, premalignant lesions, and lymph node metastases within five cases of prostate cancer, we demonstrate that both DNA methylation and copy-number heterogeneity consistently reflect the life history of the tumors. Furthermore, we show cases of genetic or epigenetic convergent evolution and highlight the diversity in the evolutionary origins and aberration spectrum between tumor and metastatic subclones. Importantly, DNA methylation can complement genetic data by serving as a proxy for activity at regulatory domains, as we show through identification of high epigenetic heterogeneity at androgen-receptor-bound enhancers. Epigenome variation thereby expands on the current genome-centric view on tumor heterogeneity.",
author = "David Brocks and Yassen Assenov and Sarah Minner and Olga Bogatyrova and Ronald Simon and Christina Koop and Christopher Oakes and Manuela Zucknick and Lipka, {Daniel Bernhard} and Joachim Weischenfeldt and Lars Feuerbach and {Cowper-Sal Lari}, Richard and Mathieu Lupien and Benedikt Brors and Jan Korbel and Thorsten Schlomm and Amos Tanay and Guido Sauter and Clarissa Gerh{\"a}user and Christoph Plass and {ICGC Early Onset Prostate Cancer Project}",
note = "Copyright {\textcopyright} 2014 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = aug,
day = "7",
doi = "10.1016/j.celrep.2014.06.053",
language = "English",
volume = "8",
pages = "798--806",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer

AU - Brocks, David

AU - Assenov, Yassen

AU - Minner, Sarah

AU - Bogatyrova, Olga

AU - Simon, Ronald

AU - Koop, Christina

AU - Oakes, Christopher

AU - Zucknick, Manuela

AU - Lipka, Daniel Bernhard

AU - Weischenfeldt, Joachim

AU - Feuerbach, Lars

AU - Cowper-Sal Lari, Richard

AU - Lupien, Mathieu

AU - Brors, Benedikt

AU - Korbel, Jan

AU - Schlomm, Thorsten

AU - Tanay, Amos

AU - Sauter, Guido

AU - Gerhäuser, Clarissa

AU - Plass, Christoph

AU - ICGC Early Onset Prostate Cancer Project

N1 - Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we show that the prostate intratumor heterogeneity in DNA methylation and copy-number patterns can be explained by a unified evolutionary process. By assaying multiple topographically distinct tumor sites, premalignant lesions, and lymph node metastases within five cases of prostate cancer, we demonstrate that both DNA methylation and copy-number heterogeneity consistently reflect the life history of the tumors. Furthermore, we show cases of genetic or epigenetic convergent evolution and highlight the diversity in the evolutionary origins and aberration spectrum between tumor and metastatic subclones. Importantly, DNA methylation can complement genetic data by serving as a proxy for activity at regulatory domains, as we show through identification of high epigenetic heterogeneity at androgen-receptor-bound enhancers. Epigenome variation thereby expands on the current genome-centric view on tumor heterogeneity.

AB - Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we show that the prostate intratumor heterogeneity in DNA methylation and copy-number patterns can be explained by a unified evolutionary process. By assaying multiple topographically distinct tumor sites, premalignant lesions, and lymph node metastases within five cases of prostate cancer, we demonstrate that both DNA methylation and copy-number heterogeneity consistently reflect the life history of the tumors. Furthermore, we show cases of genetic or epigenetic convergent evolution and highlight the diversity in the evolutionary origins and aberration spectrum between tumor and metastatic subclones. Importantly, DNA methylation can complement genetic data by serving as a proxy for activity at regulatory domains, as we show through identification of high epigenetic heterogeneity at androgen-receptor-bound enhancers. Epigenome variation thereby expands on the current genome-centric view on tumor heterogeneity.

U2 - 10.1016/j.celrep.2014.06.053

DO - 10.1016/j.celrep.2014.06.053

M3 - SCORING: Journal article

C2 - 25066126

VL - 8

SP - 798

EP - 806

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 3

ER -