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Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury.

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Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury. / Papastefanaki, Florentia; Jakovcevski, Igor; Poulia, Nafsika ; Djogo, Nevena; Schulz, Florian; Martinovic, Tamara ; Ciric, Darko; Loers, Gabriele; Vossmeyer, Tobias; Weller, Horst; Schachner, Melitta; Matsas, Rebecca.

in: MOL THER, Jahrgang 23, Nr. 6, 25.03.2015, S. 993-1002.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Papastefanaki, F, Jakovcevski, I, Poulia, N, Djogo, N, Schulz, F, Martinovic, T, Ciric, D, Loers, G, Vossmeyer, T, Weller, H, Schachner, M & Matsas, R 2015, 'Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury.', MOL THER, Jg. 23, Nr. 6, S. 993-1002. https://doi.org/doi: 10.1038/mt.2015.50

APA

Papastefanaki, F., Jakovcevski, I., Poulia, N., Djogo, N., Schulz, F., Martinovic, T., Ciric, D., Loers, G., Vossmeyer, T., Weller, H., Schachner, M., & Matsas, R. (2015). Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury. MOL THER, 23(6), 993-1002. https://doi.org/doi: 10.1038/mt.2015.50

Vancouver

Papastefanaki F, Jakovcevski I, Poulia N, Djogo N, Schulz F, Martinovic T et al. Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury. MOL THER. 2015 Mär 25;23(6):993-1002. https://doi.org/doi: 10.1038/mt.2015.50

Bibtex

@article{b2fc0d2f522045d7b9019c67656e4b8e,
title = "Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury.",
abstract = "Failure of the mammalian central nervous system (CNS) to regenerate effectively after injury leads to mostly irreversible functional impairment. Gold nanoparticles (AuNPs) are promising candidates for drug delivery in combination with tissue-compatible reagents, such as polyethylene glycol (PEG). PEG administration in CNS injury models has received interest for potential therapy, but toxicity and low bioavailability prevents clinical application. Here we show that intraspinal delivery of PEG-functionalized 40-nm-AuNPs at early stages after mouse spinal cord injury is beneficial for recovery. Positive outcome of hind limb motor function was accompanied by attenuated inflammatory response, enhanced motor neuron survival, and increased myelination of spared or regrown/sprouted axons. No adverse effects, such as body weight loss, ill health, or increased mortality were observed. We propose that PEG-AuNPs represent a favorable drug-delivery platform with therapeutic potential that could be further enhanced if PEG-AuNPs are used as carriers of regeneration-promoting molecules.",
author = "Florentia Papastefanaki and Igor Jakovcevski and Nafsika Poulia and Nevena Djogo and Florian Schulz and Tamara Martinovic and Darko Ciric and Gabriele Loers and Tobias Vossmeyer and Horst Weller and Melitta Schachner and Rebecca Matsas",
year = "2015",
month = mar,
day = "25",
doi = "doi: 10.1038/mt.2015.50",
language = "English",
volume = "23",
pages = "993--1002",
journal = "MOL THER",
issn = "1525-0016",
publisher = "NATURE PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury.

AU - Papastefanaki, Florentia

AU - Jakovcevski, Igor

AU - Poulia, Nafsika

AU - Djogo, Nevena

AU - Schulz, Florian

AU - Martinovic, Tamara

AU - Ciric, Darko

AU - Loers, Gabriele

AU - Vossmeyer, Tobias

AU - Weller, Horst

AU - Schachner, Melitta

AU - Matsas, Rebecca

PY - 2015/3/25

Y1 - 2015/3/25

N2 - Failure of the mammalian central nervous system (CNS) to regenerate effectively after injury leads to mostly irreversible functional impairment. Gold nanoparticles (AuNPs) are promising candidates for drug delivery in combination with tissue-compatible reagents, such as polyethylene glycol (PEG). PEG administration in CNS injury models has received interest for potential therapy, but toxicity and low bioavailability prevents clinical application. Here we show that intraspinal delivery of PEG-functionalized 40-nm-AuNPs at early stages after mouse spinal cord injury is beneficial for recovery. Positive outcome of hind limb motor function was accompanied by attenuated inflammatory response, enhanced motor neuron survival, and increased myelination of spared or regrown/sprouted axons. No adverse effects, such as body weight loss, ill health, or increased mortality were observed. We propose that PEG-AuNPs represent a favorable drug-delivery platform with therapeutic potential that could be further enhanced if PEG-AuNPs are used as carriers of regeneration-promoting molecules.

AB - Failure of the mammalian central nervous system (CNS) to regenerate effectively after injury leads to mostly irreversible functional impairment. Gold nanoparticles (AuNPs) are promising candidates for drug delivery in combination with tissue-compatible reagents, such as polyethylene glycol (PEG). PEG administration in CNS injury models has received interest for potential therapy, but toxicity and low bioavailability prevents clinical application. Here we show that intraspinal delivery of PEG-functionalized 40-nm-AuNPs at early stages after mouse spinal cord injury is beneficial for recovery. Positive outcome of hind limb motor function was accompanied by attenuated inflammatory response, enhanced motor neuron survival, and increased myelination of spared or regrown/sprouted axons. No adverse effects, such as body weight loss, ill health, or increased mortality were observed. We propose that PEG-AuNPs represent a favorable drug-delivery platform with therapeutic potential that could be further enhanced if PEG-AuNPs are used as carriers of regeneration-promoting molecules.

U2 - doi: 10.1038/mt.2015.50

DO - doi: 10.1038/mt.2015.50

M3 - SCORING: Journal article

VL - 23

SP - 993

EP - 1002

JO - MOL THER

JF - MOL THER

SN - 1525-0016

IS - 6

ER -