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Intrarenal production of B-cell survival factors in human lupus nephritis

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Intrarenal production of B-cell survival factors in human lupus nephritis. / Neusser, Matthias A; Lindenmeyer, Maja T; Edenhofer, Ilka; Gaiser, Stefanie; Kretzler, Matthias; Regele, Heinz; Segerer, Stephan; Cohen, Clemens D.

in: MODERN PATHOL, Jahrgang 24, Nr. 1, 01.2011, S. 98-107.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Neusser, MA, Lindenmeyer, MT, Edenhofer, I, Gaiser, S, Kretzler, M, Regele, H, Segerer, S & Cohen, CD 2011, 'Intrarenal production of B-cell survival factors in human lupus nephritis', MODERN PATHOL, Jg. 24, Nr. 1, S. 98-107. https://doi.org/10.1038/modpathol.2010.184

APA

Neusser, M. A., Lindenmeyer, M. T., Edenhofer, I., Gaiser, S., Kretzler, M., Regele, H., Segerer, S., & Cohen, C. D. (2011). Intrarenal production of B-cell survival factors in human lupus nephritis. MODERN PATHOL, 24(1), 98-107. https://doi.org/10.1038/modpathol.2010.184

Vancouver

Neusser MA, Lindenmeyer MT, Edenhofer I, Gaiser S, Kretzler M, Regele H et al. Intrarenal production of B-cell survival factors in human lupus nephritis. MODERN PATHOL. 2011 Jan;24(1):98-107. https://doi.org/10.1038/modpathol.2010.184

Bibtex

@article{46640a7516f54c39a4bd6bc6511d90fa,
title = "Intrarenal production of B-cell survival factors in human lupus nephritis",
abstract = "The B-cell survival factors APRIL and BLyS are important for B-cell maturation and activation and contribute to human autoimmune diseases. Interference with B-cell function by targeting these molecules is currently being investigated in large clinical trials for systemic lupus erythematosus. The local expression patterns of APRIL and BLyS have not been investigated in detail in kidneys with lupus nephritis. We studied the mRNA expression of APRIL, BLyS, and the corresponding receptors BCMA, TACI, and BAFF-R in microdissected human biopsies with proliferative lupus nephritis (n=25) and compared it with pretransplant biopsies of living donors (n=9). APRIL and BLyS mRNA levels were significantly higher in glomeruli of patients with proliferative lupus nephritis (12- and 30-fold, respectively). Tubulointerstitial expression of APRIL, BLyS, BCMA, and TACI was also significantly elevated. To localize the respective proteins in the kidney, APRIL, BLyS, and BAFF-R were studied by immunohistochemistry in renal biopsies with proliferative (n=21) or membranous (n=8) lupus nephritis. APRIL was prominently expressed in glomeruli with proliferative, but not membranous, lupus nephritis. The staining pattern was consistent with mesangial cells. A prominent accumulation of CD68-positive cells was present in glomeruli in association with APRIL expression. APRIL, BLyS, and BAFF-R were also expressed in interstitial inflammatory cell accumulation. This is the first study, which details local expression of APRIL and BLyS in glomeruli and tubulointerstitium of human proliferative lupus nephritis. This information might help define intrarenal effects of APRIL and BLyS inhibition in human lupus nephritis.",
keywords = "Adolescent, Adult, Aged, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocytes, Cell Survival, Female, Gene Expression, Glomerulonephritis, Membranoproliferative, Glomerulonephritis, Membranous, Humans, Immunohistochemistry, Kidney Glomerulus, Lupus Nephritis, Male, Microdissection, Middle Aged, RNA, Messenger, Tumor Necrosis Factor Ligand Superfamily Member 13, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Neusser, {Matthias A} and Lindenmeyer, {Maja T} and Ilka Edenhofer and Stefanie Gaiser and Matthias Kretzler and Heinz Regele and Stephan Segerer and Cohen, {Clemens D}",
year = "2011",
month = jan,
doi = "10.1038/modpathol.2010.184",
language = "English",
volume = "24",
pages = "98--107",
journal = "MODERN PATHOL",
issn = "0893-3952",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Intrarenal production of B-cell survival factors in human lupus nephritis

AU - Neusser, Matthias A

AU - Lindenmeyer, Maja T

AU - Edenhofer, Ilka

AU - Gaiser, Stefanie

AU - Kretzler, Matthias

AU - Regele, Heinz

AU - Segerer, Stephan

AU - Cohen, Clemens D

PY - 2011/1

Y1 - 2011/1

N2 - The B-cell survival factors APRIL and BLyS are important for B-cell maturation and activation and contribute to human autoimmune diseases. Interference with B-cell function by targeting these molecules is currently being investigated in large clinical trials for systemic lupus erythematosus. The local expression patterns of APRIL and BLyS have not been investigated in detail in kidneys with lupus nephritis. We studied the mRNA expression of APRIL, BLyS, and the corresponding receptors BCMA, TACI, and BAFF-R in microdissected human biopsies with proliferative lupus nephritis (n=25) and compared it with pretransplant biopsies of living donors (n=9). APRIL and BLyS mRNA levels were significantly higher in glomeruli of patients with proliferative lupus nephritis (12- and 30-fold, respectively). Tubulointerstitial expression of APRIL, BLyS, BCMA, and TACI was also significantly elevated. To localize the respective proteins in the kidney, APRIL, BLyS, and BAFF-R were studied by immunohistochemistry in renal biopsies with proliferative (n=21) or membranous (n=8) lupus nephritis. APRIL was prominently expressed in glomeruli with proliferative, but not membranous, lupus nephritis. The staining pattern was consistent with mesangial cells. A prominent accumulation of CD68-positive cells was present in glomeruli in association with APRIL expression. APRIL, BLyS, and BAFF-R were also expressed in interstitial inflammatory cell accumulation. This is the first study, which details local expression of APRIL and BLyS in glomeruli and tubulointerstitium of human proliferative lupus nephritis. This information might help define intrarenal effects of APRIL and BLyS inhibition in human lupus nephritis.

AB - The B-cell survival factors APRIL and BLyS are important for B-cell maturation and activation and contribute to human autoimmune diseases. Interference with B-cell function by targeting these molecules is currently being investigated in large clinical trials for systemic lupus erythematosus. The local expression patterns of APRIL and BLyS have not been investigated in detail in kidneys with lupus nephritis. We studied the mRNA expression of APRIL, BLyS, and the corresponding receptors BCMA, TACI, and BAFF-R in microdissected human biopsies with proliferative lupus nephritis (n=25) and compared it with pretransplant biopsies of living donors (n=9). APRIL and BLyS mRNA levels were significantly higher in glomeruli of patients with proliferative lupus nephritis (12- and 30-fold, respectively). Tubulointerstitial expression of APRIL, BLyS, BCMA, and TACI was also significantly elevated. To localize the respective proteins in the kidney, APRIL, BLyS, and BAFF-R were studied by immunohistochemistry in renal biopsies with proliferative (n=21) or membranous (n=8) lupus nephritis. APRIL was prominently expressed in glomeruli with proliferative, but not membranous, lupus nephritis. The staining pattern was consistent with mesangial cells. A prominent accumulation of CD68-positive cells was present in glomeruli in association with APRIL expression. APRIL, BLyS, and BAFF-R were also expressed in interstitial inflammatory cell accumulation. This is the first study, which details local expression of APRIL and BLyS in glomeruli and tubulointerstitium of human proliferative lupus nephritis. This information might help define intrarenal effects of APRIL and BLyS inhibition in human lupus nephritis.

KW - Adolescent

KW - Adult

KW - Aged

KW - B-Cell Activating Factor

KW - B-Cell Activation Factor Receptor

KW - B-Lymphocytes

KW - Cell Survival

KW - Female

KW - Gene Expression

KW - Glomerulonephritis, Membranoproliferative

KW - Glomerulonephritis, Membranous

KW - Humans

KW - Immunohistochemistry

KW - Kidney Glomerulus

KW - Lupus Nephritis

KW - Male

KW - Microdissection

KW - Middle Aged

KW - RNA, Messenger

KW - Tumor Necrosis Factor Ligand Superfamily Member 13

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/modpathol.2010.184

DO - 10.1038/modpathol.2010.184

M3 - SCORING: Journal article

C2 - 20890272

VL - 24

SP - 98

EP - 107

JO - MODERN PATHOL

JF - MODERN PATHOL

SN - 0893-3952

IS - 1

ER -