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Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice

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Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice. / von der Goltz, C; Jahn, Holger; Mutschler, J; Wiedemann, K; Kiefer, F.

in: PHARMACOPSYCHIATRY, Jahrgang 47, Nr. 3, 01.05.2014, S. 97-100.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

von der Goltz, C, Jahn, H, Mutschler, J, Wiedemann, K & Kiefer, F 2014, 'Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice', PHARMACOPSYCHIATRY, Jg. 47, Nr. 3, S. 97-100. https://doi.org/10.1055/s-0034-1372645

APA

von der Goltz, C., Jahn, H., Mutschler, J., Wiedemann, K., & Kiefer, F. (2014). Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice. PHARMACOPSYCHIATRY, 47(3), 97-100. https://doi.org/10.1055/s-0034-1372645

Vancouver

von der Goltz C, Jahn H, Mutschler J, Wiedemann K, Kiefer F. Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice. PHARMACOPSYCHIATRY. 2014 Mai 1;47(3):97-100. https://doi.org/10.1055/s-0034-1372645

Bibtex

@article{0b993333fd934b37a7d7f78b470def34,
title = "Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice",
abstract = "Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.",
keywords = "Alcohol Drinking, Animals, Anti-Anxiety Agents, Anxiety, Atrial Natriuretic Factor, Disease Models, Animal, Ethanol, Exploratory Behavior, Injections, Intraperitoneal, Male, Maze Learning, Mice, Statistics, Nonparametric, Substance Withdrawal Syndrome",
author = "{von der Goltz}, C and Holger Jahn and J Mutschler and K Wiedemann and F Kiefer",
note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",
year = "2014",
month = may,
day = "1",
doi = "10.1055/s-0034-1372645",
language = "English",
volume = "47",
pages = "97--100",
journal = "PHARMACOPSYCHIATRY",
issn = "0176-3679",
publisher = "Georg Thieme Verlag KG",
number = "3",

}

RIS

TY - JOUR

T1 - Intraperitoneal atrial natriuretic peptide attenuates anxiety-related behaviour during alcohol withdrawal in mice

AU - von der Goltz, C

AU - Jahn, Holger

AU - Mutschler, J

AU - Wiedemann, K

AU - Kiefer, F

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.

AB - Converging evidence from both preclinical and clinical studies suggests atrial natriuretic peptide (ANP) as a potential target for treatment of alcohol withdrawal and dependence. Since ANP tightly interacts with hypothalamic-pituitary-adrenocortical (HPA) axis activity, especially the modulation of stress-related anxiety during alcohol withdrawal might mediate these effects. We have now evaluated the anxiolytic activity of intraperitoneal ANP application during alcohol withdrawal in alcohol-habituated mice (C57/Bl6J). Anxiety related behaviour was attenuated during ethanol withdrawal following application of ANP (60 μg/kg) vs. saline. Our results support that anxiolytic effects of ANP mediate ANP-related gene effects with clinical data on withdrawal symptomatology.

KW - Alcohol Drinking

KW - Animals

KW - Anti-Anxiety Agents

KW - Anxiety

KW - Atrial Natriuretic Factor

KW - Disease Models, Animal

KW - Ethanol

KW - Exploratory Behavior

KW - Injections, Intraperitoneal

KW - Male

KW - Maze Learning

KW - Mice

KW - Statistics, Nonparametric

KW - Substance Withdrawal Syndrome

U2 - 10.1055/s-0034-1372645

DO - 10.1055/s-0034-1372645

M3 - SCORING: Journal article

C2 - 24846084

VL - 47

SP - 97

EP - 100

JO - PHARMACOPSYCHIATRY

JF - PHARMACOPSYCHIATRY

SN - 0176-3679

IS - 3

ER -