Intestinal absorption of iron from 59Fe-labelled hexacyanoferrates(II) in piglets.
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Intestinal absorption of iron from 59Fe-labelled hexacyanoferrates(II) in piglets. / Nielsen, Peter; Dresow, B; Fischer, R; Gabbe, E E; Heinrich, H C; Pfau, A A.
in: ARZNEIMITTEL-FORSCH, Jahrgang 38, Nr. 10, 10, 1988, S. 1469-1471.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Intestinal absorption of iron from 59Fe-labelled hexacyanoferrates(II) in piglets.
AU - Nielsen, Peter
AU - Dresow, B
AU - Fischer, R
AU - Gabbe, E E
AU - Heinrich, H C
AU - Pfau, A A
PY - 1988
Y1 - 1988
N2 - The intestinal absorption of 59Fe and 14C from hexacyanoferrates(II) was studied in piglets. KFeIII[FeII (CN)6] (I) and FeIII4[FeII(CN)6]3 (II) were labelled with 59Fe both in the Fe(III)-position (outside the complex anion, a) or in the Fe(II)-position (hexacyanoferrate anion, b). Labelling of the Fe(III)-position resulted in a 59Fe-absorption of 1.47% (Ia) and 1.34% (IIa), as judged by the 59Fe whole-body-retention measurement 14 days after oral administration. Even smaller amounts, 0.20% from Ib or 0.15% from IIb of the 59Fe-dose were absorbed and retained from the hexacyanoferrates(II) labelled in the Fe(II)-position. No 14CO2 was detected in the expired air of piglets after oral application of Fe4[59Fe(14CN)6]3, indicating that the amount of incorporated free cyanide ions can only be extremely small or even nil.
AB - The intestinal absorption of 59Fe and 14C from hexacyanoferrates(II) was studied in piglets. KFeIII[FeII (CN)6] (I) and FeIII4[FeII(CN)6]3 (II) were labelled with 59Fe both in the Fe(III)-position (outside the complex anion, a) or in the Fe(II)-position (hexacyanoferrate anion, b). Labelling of the Fe(III)-position resulted in a 59Fe-absorption of 1.47% (Ia) and 1.34% (IIa), as judged by the 59Fe whole-body-retention measurement 14 days after oral administration. Even smaller amounts, 0.20% from Ib or 0.15% from IIb of the 59Fe-dose were absorbed and retained from the hexacyanoferrates(II) labelled in the Fe(II)-position. No 14CO2 was detected in the expired air of piglets after oral application of Fe4[59Fe(14CN)6]3, indicating that the amount of incorporated free cyanide ions can only be extremely small or even nil.
M3 - SCORING: Zeitschriftenaufsatz
VL - 38
SP - 1469
EP - 1471
IS - 10
M1 - 10
ER -
