Interstitial high-dose rate brachytherapy with iridium-192 in patients with oral squamous cell carcinoma.
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Interstitial high-dose rate brachytherapy with iridium-192 in patients with oral squamous cell carcinoma. / Friedrich, R E; Krüll, Andreas; Hellner, D; Schwarz, R; Heyer, D; Plambeck, K; Schmelzle, R.
in: J CRANIO MAXILL SURG, Jahrgang 23, Nr. 4, 4, 1995, S. 238-242.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Interstitial high-dose rate brachytherapy with iridium-192 in patients with oral squamous cell carcinoma.
AU - Friedrich, R E
AU - Krüll, Andreas
AU - Hellner, D
AU - Schwarz, R
AU - Heyer, D
AU - Plambeck, K
AU - Schmelzle, R
PY - 1995
Y1 - 1995
N2 - Thirty-four patients with recurrent oral and oropharyngeal carcinomas were treated over a period of 4 years, by interstitial high-dose rate (HDR) brachytherapy (BT) using an iridium-192 source (Gammamed 2i and 12i equipment, Sauerwein, Germany) and fractionated application (1 up to 3 times, weekly recovery phases, single maximum dose 10 Gy). Pretreatment characteristics of patients in terms of irradiation (RT) and surgery differed (22 had external RT alone, with a total dose between 60.0 and 75.6 Gy; RT and surgery: 7; surgery alone: 1). The initial TNM-stages (UICC, Hermanek et al., 1987) of patients were: I = 2, II =3, III = 7, IV = 22. In the majority of cases, clinical indications for HDR-BT included tumour recurrence or progression following external RT, and second primary tumours of the oral cavity. Therapy was successful in most cases, i.e. complete remission: 11, partial remission: 16, no change: 2, progression: 5. Local control and overall survival rates, including patients surgically treated after BT, were at 6 months 58% and 62%, and 44% and 53% at 12 months, respectively. This type of treatment is recommended in patients with local recurrence or second primary tumours after previous external RT in the head and neck region. However, the benefit of interstitial HDR-BT remains questionable, particularly in patients with large tumours and lymph node metastases.
AB - Thirty-four patients with recurrent oral and oropharyngeal carcinomas were treated over a period of 4 years, by interstitial high-dose rate (HDR) brachytherapy (BT) using an iridium-192 source (Gammamed 2i and 12i equipment, Sauerwein, Germany) and fractionated application (1 up to 3 times, weekly recovery phases, single maximum dose 10 Gy). Pretreatment characteristics of patients in terms of irradiation (RT) and surgery differed (22 had external RT alone, with a total dose between 60.0 and 75.6 Gy; RT and surgery: 7; surgery alone: 1). The initial TNM-stages (UICC, Hermanek et al., 1987) of patients were: I = 2, II =3, III = 7, IV = 22. In the majority of cases, clinical indications for HDR-BT included tumour recurrence or progression following external RT, and second primary tumours of the oral cavity. Therapy was successful in most cases, i.e. complete remission: 11, partial remission: 16, no change: 2, progression: 5. Local control and overall survival rates, including patients surgically treated after BT, were at 6 months 58% and 62%, and 44% and 53% at 12 months, respectively. This type of treatment is recommended in patients with local recurrence or second primary tumours after previous external RT in the head and neck region. However, the benefit of interstitial HDR-BT remains questionable, particularly in patients with large tumours and lymph node metastases.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Treatment Outcome
KW - Survival Rate
KW - Neoplasm Staging
KW - Dose-Response Relationship, Radiation
KW - Brachytherapy/methods
KW - Carcinoma, Squamous Cell/pathology/radiotherapy
KW - Iridium Radioisotopes/diagnostic use
KW - Mouth Neoplasms/pathology/radiotherapy
KW - Neoplasm Recurrence, Local/pathology/radiotherapy
KW - Oropharyngeal Neoplasms/pathology/radiotherapy
KW - Radiotherapy, High-Energy
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Treatment Outcome
KW - Survival Rate
KW - Neoplasm Staging
KW - Dose-Response Relationship, Radiation
KW - Brachytherapy/methods
KW - Carcinoma, Squamous Cell/pathology/radiotherapy
KW - Iridium Radioisotopes/diagnostic use
KW - Mouth Neoplasms/pathology/radiotherapy
KW - Neoplasm Recurrence, Local/pathology/radiotherapy
KW - Oropharyngeal Neoplasms/pathology/radiotherapy
KW - Radiotherapy, High-Energy
M3 - SCORING: Journal article
VL - 23
SP - 238
EP - 242
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 4
M1 - 4
ER -
