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Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients

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Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients. / Hipp, Susanne; Berg, Daniela; Ergin, Bilge; Schuster, Tibor; Hapfelmeier, Alexander; Walch, Axel; Avril, Stefanie; Schmalfeldt, Barbara; Höfler, Heinz; Becker, Karl-Friedrich.

in: VIRCHOWS ARCH, Jahrgang 457, Nr. 6, 12.2010, S. 705-13.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hipp, S, Berg, D, Ergin, B, Schuster, T, Hapfelmeier, A, Walch, A, Avril, S, Schmalfeldt, B, Höfler, H & Becker, K-F 2010, 'Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients', VIRCHOWS ARCH, Jg. 457, Nr. 6, S. 705-13. https://doi.org/10.1007/s00428-010-0986-5

APA

Hipp, S., Berg, D., Ergin, B., Schuster, T., Hapfelmeier, A., Walch, A., Avril, S., Schmalfeldt, B., Höfler, H., & Becker, K-F. (2010). Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients. VIRCHOWS ARCH, 457(6), 705-13. https://doi.org/10.1007/s00428-010-0986-5

Vancouver

Hipp S, Berg D, Ergin B, Schuster T, Hapfelmeier A, Walch A et al. Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients. VIRCHOWS ARCH. 2010 Dez;457(6):705-13. https://doi.org/10.1007/s00428-010-0986-5

Bibtex

@article{44e979a7c5e5418cbae84f27518d5cdd,
title = "Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients",
abstract = "Epithelial ovarian cancer is a highly metastatic disease and the leading cause of death among cancer of the female genital tract. Abnormal epidermal growth factor receptor (EGFR) signalling has been shown to be involved in epithelial-mesenchymal transition (EMT), an early step during metastasis. Additionally, over-expression of the E-cadherin repressor Snail, a key regulator of EMT, has previously been found to be associated with unfavourable prognostic features. Thus, the aim of our study was to elucidate the role of EGFR-dependent signalling pathways for Snail expression in ovarian cancer. For this purpose, we analysed 25 formalin-fixed and paraffin-embedded (FFPE) primary tumours and their corresponding metastases for the expression of 25 signalling pathway molecules by reverse phase protein arrays. We found a significant correlation of Snail with EGFR((Tyr1086)) and p38 MAPK((Thr180/Tyr182)) in primary ovarian carcinoma and with EGFR((Tyr1086)) in their corresponding metastasis. Additionally, we showed that high expression levels of Snail in primary tumours combined with high expression levels of the phosphorylated p38 MAPK((Thr180/Tyr182)) in metastasis lead to an increased risk for death in ovarian carcinoma patients. Thus, for future combinatorial cancer therapy, drug combinations that best target the deregulated protein network in each individual patient should be selected.",
keywords = "Female, Follow-Up Studies, Humans, Neoplasms, Cystic, Mucinous, and Serous, Ovarian Neoplasms, Prognosis, Receptor, Epidermal Growth Factor, Retrospective Studies, Signal Transduction, Survival Rate, Transcription Factors, p38 Mitogen-Activated Protein Kinases",
author = "Susanne Hipp and Daniela Berg and Bilge Ergin and Tibor Schuster and Alexander Hapfelmeier and Axel Walch and Stefanie Avril and Barbara Schmalfeldt and Heinz H{\"o}fler and Karl-Friedrich Becker",
year = "2010",
month = dec,
doi = "10.1007/s00428-010-0986-5",
language = "English",
volume = "457",
pages = "705--13",
journal = "VIRCHOWS ARCH",
issn = "0945-6317",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients

AU - Hipp, Susanne

AU - Berg, Daniela

AU - Ergin, Bilge

AU - Schuster, Tibor

AU - Hapfelmeier, Alexander

AU - Walch, Axel

AU - Avril, Stefanie

AU - Schmalfeldt, Barbara

AU - Höfler, Heinz

AU - Becker, Karl-Friedrich

PY - 2010/12

Y1 - 2010/12

N2 - Epithelial ovarian cancer is a highly metastatic disease and the leading cause of death among cancer of the female genital tract. Abnormal epidermal growth factor receptor (EGFR) signalling has been shown to be involved in epithelial-mesenchymal transition (EMT), an early step during metastasis. Additionally, over-expression of the E-cadherin repressor Snail, a key regulator of EMT, has previously been found to be associated with unfavourable prognostic features. Thus, the aim of our study was to elucidate the role of EGFR-dependent signalling pathways for Snail expression in ovarian cancer. For this purpose, we analysed 25 formalin-fixed and paraffin-embedded (FFPE) primary tumours and their corresponding metastases for the expression of 25 signalling pathway molecules by reverse phase protein arrays. We found a significant correlation of Snail with EGFR((Tyr1086)) and p38 MAPK((Thr180/Tyr182)) in primary ovarian carcinoma and with EGFR((Tyr1086)) in their corresponding metastasis. Additionally, we showed that high expression levels of Snail in primary tumours combined with high expression levels of the phosphorylated p38 MAPK((Thr180/Tyr182)) in metastasis lead to an increased risk for death in ovarian carcinoma patients. Thus, for future combinatorial cancer therapy, drug combinations that best target the deregulated protein network in each individual patient should be selected.

AB - Epithelial ovarian cancer is a highly metastatic disease and the leading cause of death among cancer of the female genital tract. Abnormal epidermal growth factor receptor (EGFR) signalling has been shown to be involved in epithelial-mesenchymal transition (EMT), an early step during metastasis. Additionally, over-expression of the E-cadherin repressor Snail, a key regulator of EMT, has previously been found to be associated with unfavourable prognostic features. Thus, the aim of our study was to elucidate the role of EGFR-dependent signalling pathways for Snail expression in ovarian cancer. For this purpose, we analysed 25 formalin-fixed and paraffin-embedded (FFPE) primary tumours and their corresponding metastases for the expression of 25 signalling pathway molecules by reverse phase protein arrays. We found a significant correlation of Snail with EGFR((Tyr1086)) and p38 MAPK((Thr180/Tyr182)) in primary ovarian carcinoma and with EGFR((Tyr1086)) in their corresponding metastasis. Additionally, we showed that high expression levels of Snail in primary tumours combined with high expression levels of the phosphorylated p38 MAPK((Thr180/Tyr182)) in metastasis lead to an increased risk for death in ovarian carcinoma patients. Thus, for future combinatorial cancer therapy, drug combinations that best target the deregulated protein network in each individual patient should be selected.

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Neoplasms, Cystic, Mucinous, and Serous

KW - Ovarian Neoplasms

KW - Prognosis

KW - Receptor, Epidermal Growth Factor

KW - Retrospective Studies

KW - Signal Transduction

KW - Survival Rate

KW - Transcription Factors

KW - p38 Mitogen-Activated Protein Kinases

U2 - 10.1007/s00428-010-0986-5

DO - 10.1007/s00428-010-0986-5

M3 - SCORING: Journal article

C2 - 20957493

VL - 457

SP - 705

EP - 713

JO - VIRCHOWS ARCH

JF - VIRCHOWS ARCH

SN - 0945-6317

IS - 6

ER -