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Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice

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Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice. / Kleene, Ralf; Chaudhary, Harshita; Karl, Nicole; Katic, Jelena; Kotarska, Agnieszka; Guitart, Kathrin; Loers, Gabriele; Schachner, Melitta.

in: J CELL SCI, Jahrgang 128, Nr. 24, 15.12.2015, S. 4642-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kleene, R, Chaudhary, H, Karl, N, Katic, J, Kotarska, A, Guitart, K, Loers, G & Schachner, M 2015, 'Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice', J CELL SCI, Jg. 128, Nr. 24, S. 4642-52. https://doi.org/10.1242/jcs.176941

APA

Kleene, R., Chaudhary, H., Karl, N., Katic, J., Kotarska, A., Guitart, K., Loers, G., & Schachner, M. (2015). Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice. J CELL SCI, 128(24), 4642-52. https://doi.org/10.1242/jcs.176941

Vancouver

Kleene R, Chaudhary H, Karl N, Katic J, Kotarska A, Guitart K et al. Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice. J CELL SCI. 2015 Dez 15;128(24):4642-52. https://doi.org/10.1242/jcs.176941

Bibtex

@article{a25907faac9848a194ca8924ad8a2dd3,
title = "Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice",
abstract = "The serotonergic system plays important roles in multiple functions of the nervous system and its malfunctioning leads to neurological and psychiatric disorders. Here, we show that the cell adhesion molecule close homolog of L1 (CHL1), which has been linked to mental disorders, binds to a peptide stretch in the third intracellular loop of the serotonin 2c (5-HT2c) receptor through its intracellular domain. Moreover, we provide evidence that CHL1 deficiency in mice leads to 5-HT2c-receptor-related reduction in locomotor activity and reactivity to novelty, and that CHL1 regulates signaling pathways triggered by constitutively active isoforms of the 5-HT2c receptor. Furthermore, we found that the 5-HT2c receptor and CHL1 colocalize in striatal and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.",
author = "Ralf Kleene and Harshita Chaudhary and Nicole Karl and Jelena Katic and Agnieszka Kotarska and Kathrin Guitart and Gabriele Loers and Melitta Schachner",
note = "{\textcopyright} 2015. Published by The Company of Biologists Ltd.",
year = "2015",
month = dec,
day = "15",
doi = "10.1242/jcs.176941",
language = "English",
volume = "128",
pages = "4642--52",
journal = "J CELL SCI",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "24",

}

RIS

TY - JOUR

T1 - Interaction between CHL1 and serotonin receptor 2c regulates signal transduction and behavior in mice

AU - Kleene, Ralf

AU - Chaudhary, Harshita

AU - Karl, Nicole

AU - Katic, Jelena

AU - Kotarska, Agnieszka

AU - Guitart, Kathrin

AU - Loers, Gabriele

AU - Schachner, Melitta

N1 - © 2015. Published by The Company of Biologists Ltd.

PY - 2015/12/15

Y1 - 2015/12/15

N2 - The serotonergic system plays important roles in multiple functions of the nervous system and its malfunctioning leads to neurological and psychiatric disorders. Here, we show that the cell adhesion molecule close homolog of L1 (CHL1), which has been linked to mental disorders, binds to a peptide stretch in the third intracellular loop of the serotonin 2c (5-HT2c) receptor through its intracellular domain. Moreover, we provide evidence that CHL1 deficiency in mice leads to 5-HT2c-receptor-related reduction in locomotor activity and reactivity to novelty, and that CHL1 regulates signaling pathways triggered by constitutively active isoforms of the 5-HT2c receptor. Furthermore, we found that the 5-HT2c receptor and CHL1 colocalize in striatal and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.

AB - The serotonergic system plays important roles in multiple functions of the nervous system and its malfunctioning leads to neurological and psychiatric disorders. Here, we show that the cell adhesion molecule close homolog of L1 (CHL1), which has been linked to mental disorders, binds to a peptide stretch in the third intracellular loop of the serotonin 2c (5-HT2c) receptor through its intracellular domain. Moreover, we provide evidence that CHL1 deficiency in mice leads to 5-HT2c-receptor-related reduction in locomotor activity and reactivity to novelty, and that CHL1 regulates signaling pathways triggered by constitutively active isoforms of the 5-HT2c receptor. Furthermore, we found that the 5-HT2c receptor and CHL1 colocalize in striatal and hippocampal GABAergic neurons, and that 5-HT2c receptor phosphorylation and its association with phosphatase and tensin homolog (PTEN) and β-arrestin 2 is regulated by CHL1. Our results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.

U2 - 10.1242/jcs.176941

DO - 10.1242/jcs.176941

M3 - SCORING: Journal article

C2 - 26527397

VL - 128

SP - 4642

EP - 4652

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - 24

ER -