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Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens

Standard

Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens. / Sauter, Guido; Clauditz, Till; Steurer, Stefan; Wittmer, Corinna; Büscheck, Franziska; Krech, Till; Lutz, Florian; Lennartz, Maximilian; Harms, Luisa; Lawrenz, Lisa; Möller-Koop, Christina; Simon, Ronald; Jacobsen, Frank; Wilczak, Waldemar; Minner, Sarah; Tsourlakis, Maria Christina; Chirico, Viktoria; Weidemann, Sören; Haese, Alexander; Steuber, Thomas; Salomon, Georg; Matiu, Michael; Vettorazzi, Eik; Michl, Uwe; Budäus, Lars; Tilki, Derya; Thederan, Imke; Pehrke, Dirk; Beyer, Burkhard; Fraune, Christoph; Göbel, Cosima; Heinrich, Marie; Juhnke, Manuela; Möller, Katharina; Bawahab, Ahmed Abdulwahab Abdullah; Uhlig, Ria; Huland, Hartwig; Heinzer, Hans; Graefen, Markus; Schlomm, Thorsten.

in: EUR UROL, Jahrgang 73, Nr. 5, 05.2018, S. 674-683.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sauter, G, Clauditz, T, Steurer, S, Wittmer, C, Büscheck, F, Krech, T, Lutz, F, Lennartz, M, Harms, L, Lawrenz, L, Möller-Koop, C, Simon, R, Jacobsen, F, Wilczak, W, Minner, S, Tsourlakis, MC, Chirico, V, Weidemann, S, Haese, A, Steuber, T, Salomon, G, Matiu, M, Vettorazzi, E, Michl, U, Budäus, L, Tilki, D, Thederan, I, Pehrke, D, Beyer, B, Fraune, C, Göbel, C, Heinrich, M, Juhnke, M, Möller, K, Bawahab, AAA, Uhlig, R, Huland, H, Heinzer, H, Graefen, M & Schlomm, T 2018, 'Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens', EUR UROL, Jg. 73, Nr. 5, S. 674-683. https://doi.org/10.1016/j.eururo.2017.01.015

APA

Sauter, G., Clauditz, T., Steurer, S., Wittmer, C., Büscheck, F., Krech, T., Lutz, F., Lennartz, M., Harms, L., Lawrenz, L., Möller-Koop, C., Simon, R., Jacobsen, F., Wilczak, W., Minner, S., Tsourlakis, M. C., Chirico, V., Weidemann, S., Haese, A., ... Schlomm, T. (2018). Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens. EUR UROL, 73(5), 674-683. https://doi.org/10.1016/j.eururo.2017.01.015

Vancouver

Sauter G, Clauditz T, Steurer S, Wittmer C, Büscheck F, Krech T et al. Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens. EUR UROL. 2018 Mai;73(5):674-683. https://doi.org/10.1016/j.eururo.2017.01.015

Bibtex

@article{3a68af14201944fda060be286dd930d3,
title = "Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens",
abstract = "BACKGROUND: Presence of small (tertiary) Gleason 5 pattern is linked to a higher risk of biochemical recurrence in prostate cancer. It is unclear, however, how to integrate small Gleason 5 elements into clinically relevant Gleason grade groups.OBJECTIVE: To analyze the prognostic impact of Gleason 5 patterns in prostate cancer and to develop a method for integrating tertiary Gleason 5 patterns into a quantitative Gleason grading system.DESIGN, SETTING, AND PARTICIPANTS: Prostatectomy specimens from 13 261 consecutive patients and of 3295 matched preoperative biopsies were available. Percentages of Gleason 3, 4, and 5 had been recorded for each cancer. Outcome measurements and statistical analysis: RESULTS AND LIMITATIONS: Our data demonstrate that minimal Gleason 5 areas have strong prognostic impact in Gleason 7 carcinomas, while further expansion of the Gleason 5 pattern population has less impact. We thus defined an integrated quantitative Gleason score (IQ-Gleason) by adding a lump score of 10 to the percentage of unfavorable Gleason pattern (Gleason 4/5) if any Gleason 5 was present and by adding another 7.5 points in case of a Gleason 5 fraction >20%. There was a continuous increase of the risk of prostate-specific antigen recurrence with increasing IQ-Gleason. This was also true for subgroups with identical Cancer of the Prostate Risk Assessment Postsurgical scores (p<0.0001) or Gleason grade groups (p<0.0001).CONCLUSIONS: The IQ-Gleason represents a simple and efficient approach for combining both quantitative Gleason grading and tertiary Gleason grades in one highly prognostic numerical variable.PATIENT SUMMARY: Prostatectomy specimens (13 261) were analyzed to estimate the relevance of small Gleason 5 elements in prostate cancers. Even the smallest Gleason 5 areas markedly increased the risk of prostate-specific antigen recurrence after surgery. Larger fractions of Gleason 5 patterns had less further impact on prognosis. Based on this, a numerical Gleason score (integrated quantitative Gleason score) was defined by the percentages of Gleason 4 and 5 patterns, enabling a refined estimate of patient prognosis.",
author = "Guido Sauter and Till Clauditz and Stefan Steurer and Corinna Wittmer and Franziska B{\"u}scheck and Till Krech and Florian Lutz and Maximilian Lennartz and Luisa Harms and Lisa Lawrenz and Christina M{\"o}ller-Koop and Ronald Simon and Frank Jacobsen and Waldemar Wilczak and Sarah Minner and Tsourlakis, {Maria Christina} and Viktoria Chirico and S{\"o}ren Weidemann and Alexander Haese and Thomas Steuber and Georg Salomon and Michael Matiu and Eik Vettorazzi and Uwe Michl and Lars Bud{\"a}us and Derya Tilki and Imke Thederan and Dirk Pehrke and Burkhard Beyer and Christoph Fraune and Cosima G{\"o}bel and Marie Heinrich and Manuela Juhnke and Katharina M{\"o}ller and Bawahab, {Ahmed Abdulwahab Abdullah} and Ria Uhlig and Hartwig Huland and Hans Heinzer and Markus Graefen and Thorsten Schlomm",
note = "Copyright {\textcopyright} 2017. Published by Elsevier B.V.",
year = "2018",
month = may,
doi = "10.1016/j.eururo.2017.01.015",
language = "English",
volume = "73",
pages = "674--683",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens

AU - Sauter, Guido

AU - Clauditz, Till

AU - Steurer, Stefan

AU - Wittmer, Corinna

AU - Büscheck, Franziska

AU - Krech, Till

AU - Lutz, Florian

AU - Lennartz, Maximilian

AU - Harms, Luisa

AU - Lawrenz, Lisa

AU - Möller-Koop, Christina

AU - Simon, Ronald

AU - Jacobsen, Frank

AU - Wilczak, Waldemar

AU - Minner, Sarah

AU - Tsourlakis, Maria Christina

AU - Chirico, Viktoria

AU - Weidemann, Sören

AU - Haese, Alexander

AU - Steuber, Thomas

AU - Salomon, Georg

AU - Matiu, Michael

AU - Vettorazzi, Eik

AU - Michl, Uwe

AU - Budäus, Lars

AU - Tilki, Derya

AU - Thederan, Imke

AU - Pehrke, Dirk

AU - Beyer, Burkhard

AU - Fraune, Christoph

AU - Göbel, Cosima

AU - Heinrich, Marie

AU - Juhnke, Manuela

AU - Möller, Katharina

AU - Bawahab, Ahmed Abdulwahab Abdullah

AU - Uhlig, Ria

AU - Huland, Hartwig

AU - Heinzer, Hans

AU - Graefen, Markus

AU - Schlomm, Thorsten

N1 - Copyright © 2017. Published by Elsevier B.V.

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Presence of small (tertiary) Gleason 5 pattern is linked to a higher risk of biochemical recurrence in prostate cancer. It is unclear, however, how to integrate small Gleason 5 elements into clinically relevant Gleason grade groups.OBJECTIVE: To analyze the prognostic impact of Gleason 5 patterns in prostate cancer and to develop a method for integrating tertiary Gleason 5 patterns into a quantitative Gleason grading system.DESIGN, SETTING, AND PARTICIPANTS: Prostatectomy specimens from 13 261 consecutive patients and of 3295 matched preoperative biopsies were available. Percentages of Gleason 3, 4, and 5 had been recorded for each cancer. Outcome measurements and statistical analysis: RESULTS AND LIMITATIONS: Our data demonstrate that minimal Gleason 5 areas have strong prognostic impact in Gleason 7 carcinomas, while further expansion of the Gleason 5 pattern population has less impact. We thus defined an integrated quantitative Gleason score (IQ-Gleason) by adding a lump score of 10 to the percentage of unfavorable Gleason pattern (Gleason 4/5) if any Gleason 5 was present and by adding another 7.5 points in case of a Gleason 5 fraction >20%. There was a continuous increase of the risk of prostate-specific antigen recurrence with increasing IQ-Gleason. This was also true for subgroups with identical Cancer of the Prostate Risk Assessment Postsurgical scores (p<0.0001) or Gleason grade groups (p<0.0001).CONCLUSIONS: The IQ-Gleason represents a simple and efficient approach for combining both quantitative Gleason grading and tertiary Gleason grades in one highly prognostic numerical variable.PATIENT SUMMARY: Prostatectomy specimens (13 261) were analyzed to estimate the relevance of small Gleason 5 elements in prostate cancers. Even the smallest Gleason 5 areas markedly increased the risk of prostate-specific antigen recurrence after surgery. Larger fractions of Gleason 5 patterns had less further impact on prognosis. Based on this, a numerical Gleason score (integrated quantitative Gleason score) was defined by the percentages of Gleason 4 and 5 patterns, enabling a refined estimate of patient prognosis.

AB - BACKGROUND: Presence of small (tertiary) Gleason 5 pattern is linked to a higher risk of biochemical recurrence in prostate cancer. It is unclear, however, how to integrate small Gleason 5 elements into clinically relevant Gleason grade groups.OBJECTIVE: To analyze the prognostic impact of Gleason 5 patterns in prostate cancer and to develop a method for integrating tertiary Gleason 5 patterns into a quantitative Gleason grading system.DESIGN, SETTING, AND PARTICIPANTS: Prostatectomy specimens from 13 261 consecutive patients and of 3295 matched preoperative biopsies were available. Percentages of Gleason 3, 4, and 5 had been recorded for each cancer. Outcome measurements and statistical analysis: RESULTS AND LIMITATIONS: Our data demonstrate that minimal Gleason 5 areas have strong prognostic impact in Gleason 7 carcinomas, while further expansion of the Gleason 5 pattern population has less impact. We thus defined an integrated quantitative Gleason score (IQ-Gleason) by adding a lump score of 10 to the percentage of unfavorable Gleason pattern (Gleason 4/5) if any Gleason 5 was present and by adding another 7.5 points in case of a Gleason 5 fraction >20%. There was a continuous increase of the risk of prostate-specific antigen recurrence with increasing IQ-Gleason. This was also true for subgroups with identical Cancer of the Prostate Risk Assessment Postsurgical scores (p<0.0001) or Gleason grade groups (p<0.0001).CONCLUSIONS: The IQ-Gleason represents a simple and efficient approach for combining both quantitative Gleason grading and tertiary Gleason grades in one highly prognostic numerical variable.PATIENT SUMMARY: Prostatectomy specimens (13 261) were analyzed to estimate the relevance of small Gleason 5 elements in prostate cancers. Even the smallest Gleason 5 areas markedly increased the risk of prostate-specific antigen recurrence after surgery. Larger fractions of Gleason 5 patterns had less further impact on prognosis. Based on this, a numerical Gleason score (integrated quantitative Gleason score) was defined by the percentages of Gleason 4 and 5 patterns, enabling a refined estimate of patient prognosis.

U2 - 10.1016/j.eururo.2017.01.015

DO - 10.1016/j.eururo.2017.01.015

M3 - SCORING: Journal article

C2 - 28117112

VL - 73

SP - 674

EP - 683

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 5

ER -