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Integrated Molecular Characterization of Testicular Germ Cell Tumors

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Integrated Molecular Characterization of Testicular Germ Cell Tumors. / Shen, Hui; Shih, Juliann; Hollern, Daniel P; Wang, Linghua; Bowlby, Reanne; Tickoo, Satish K; Thorsson, Vésteinn; Mungall, Andrew J; Newton, Yulia; Hegde, Apurva M; Armenia, Joshua; Sánchez-Vega, Francisco; Pluta, John; Pyle, Louise C; Mehra, Rohit; Reuter, Victor E; Godoy, Guilherme; Jones, Jeffrey; Shelley, Carl S; Feldman, Darren R; Vidal, Daniel O; Lessel, Davor; Kulis, Tomislav; Cárcano, Flavio M; Leraas, Kristen M; Lichtenberg, Tara M; Brooks, Denise; Cherniack, Andrew D; Cho, Juok; Heiman, David I; Kasaian, Katayoon; Liu, Minwei; Noble, Michael S; Xi, Liu; Zhang, Hailei; Zhou, Wanding; ZenKlusen, Jean C; Hutter, Carolyn M; Felau, Ina; Zhang, Jiashan; Schultz, Nikolaus; Getz, Gad; Meyerson, Matthew; Stuart, Joshua M; Akbani, Rehan; Wheeler, David A; Laird, Peter W; Nathanson, Katherine L; Cortessis, Victoria K; Hoadley, Katherine A; Cancer Genome Atlas Research Network.

in: CELL REP, Jahrgang 23, Nr. 11, 12.06.2018, S. 3392-3406.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Shen, H, Shih, J, Hollern, DP, Wang, L, Bowlby, R, Tickoo, SK, Thorsson, V, Mungall, AJ, Newton, Y, Hegde, AM, Armenia, J, Sánchez-Vega, F, Pluta, J, Pyle, LC, Mehra, R, Reuter, VE, Godoy, G, Jones, J, Shelley, CS, Feldman, DR, Vidal, DO, Lessel, D, Kulis, T, Cárcano, FM, Leraas, KM, Lichtenberg, TM, Brooks, D, Cherniack, AD, Cho, J, Heiman, DI, Kasaian, K, Liu, M, Noble, MS, Xi, L, Zhang, H, Zhou, W, ZenKlusen, JC, Hutter, CM, Felau, I, Zhang, J, Schultz, N, Getz, G, Meyerson, M, Stuart, JM, Akbani, R, Wheeler, DA, Laird, PW, Nathanson, KL, Cortessis, VK, Hoadley, KA & Cancer Genome Atlas Research Network 2018, 'Integrated Molecular Characterization of Testicular Germ Cell Tumors', CELL REP, Jg. 23, Nr. 11, S. 3392-3406. https://doi.org/10.1016/j.celrep.2018.05.039

APA

Shen, H., Shih, J., Hollern, D. P., Wang, L., Bowlby, R., Tickoo, S. K., Thorsson, V., Mungall, A. J., Newton, Y., Hegde, A. M., Armenia, J., Sánchez-Vega, F., Pluta, J., Pyle, L. C., Mehra, R., Reuter, V. E., Godoy, G., Jones, J., Shelley, C. S., ... Cancer Genome Atlas Research Network (2018). Integrated Molecular Characterization of Testicular Germ Cell Tumors. CELL REP, 23(11), 3392-3406. https://doi.org/10.1016/j.celrep.2018.05.039

Vancouver

Shen H, Shih J, Hollern DP, Wang L, Bowlby R, Tickoo SK et al. Integrated Molecular Characterization of Testicular Germ Cell Tumors. CELL REP. 2018 Jun 12;23(11):3392-3406. https://doi.org/10.1016/j.celrep.2018.05.039

Bibtex

@article{f0f42cdccdba4d1fb3a3898651434c84,
title = "Integrated Molecular Characterization of Testicular Germ Cell Tumors",
abstract = "We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas.",
keywords = "Journal Article",
author = "Hui Shen and Juliann Shih and Hollern, {Daniel P} and Linghua Wang and Reanne Bowlby and Tickoo, {Satish K} and V{\'e}steinn Thorsson and Mungall, {Andrew J} and Yulia Newton and Hegde, {Apurva M} and Joshua Armenia and Francisco S{\'a}nchez-Vega and John Pluta and Pyle, {Louise C} and Rohit Mehra and Reuter, {Victor E} and Guilherme Godoy and Jeffrey Jones and Shelley, {Carl S} and Feldman, {Darren R} and Vidal, {Daniel O} and Davor Lessel and Tomislav Kulis and C{\'a}rcano, {Flavio M} and Leraas, {Kristen M} and Lichtenberg, {Tara M} and Denise Brooks and Cherniack, {Andrew D} and Juok Cho and Heiman, {David I} and Katayoon Kasaian and Minwei Liu and Noble, {Michael S} and Liu Xi and Hailei Zhang and Wanding Zhou and ZenKlusen, {Jean C} and Hutter, {Carolyn M} and Ina Felau and Jiashan Zhang and Nikolaus Schultz and Gad Getz and Matthew Meyerson and Stuart, {Joshua M} and Rehan Akbani and Wheeler, {David A} and Laird, {Peter W} and Nathanson, {Katherine L} and Cortessis, {Victoria K} and Hoadley, {Katherine A} and {Cancer Genome Atlas Research Network}",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = jun,
day = "12",
doi = "10.1016/j.celrep.2018.05.039",
language = "English",
volume = "23",
pages = "3392--3406",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Integrated Molecular Characterization of Testicular Germ Cell Tumors

AU - Shen, Hui

AU - Shih, Juliann

AU - Hollern, Daniel P

AU - Wang, Linghua

AU - Bowlby, Reanne

AU - Tickoo, Satish K

AU - Thorsson, Vésteinn

AU - Mungall, Andrew J

AU - Newton, Yulia

AU - Hegde, Apurva M

AU - Armenia, Joshua

AU - Sánchez-Vega, Francisco

AU - Pluta, John

AU - Pyle, Louise C

AU - Mehra, Rohit

AU - Reuter, Victor E

AU - Godoy, Guilherme

AU - Jones, Jeffrey

AU - Shelley, Carl S

AU - Feldman, Darren R

AU - Vidal, Daniel O

AU - Lessel, Davor

AU - Kulis, Tomislav

AU - Cárcano, Flavio M

AU - Leraas, Kristen M

AU - Lichtenberg, Tara M

AU - Brooks, Denise

AU - Cherniack, Andrew D

AU - Cho, Juok

AU - Heiman, David I

AU - Kasaian, Katayoon

AU - Liu, Minwei

AU - Noble, Michael S

AU - Xi, Liu

AU - Zhang, Hailei

AU - Zhou, Wanding

AU - ZenKlusen, Jean C

AU - Hutter, Carolyn M

AU - Felau, Ina

AU - Zhang, Jiashan

AU - Schultz, Nikolaus

AU - Getz, Gad

AU - Meyerson, Matthew

AU - Stuart, Joshua M

AU - Akbani, Rehan

AU - Wheeler, David A

AU - Laird, Peter W

AU - Nathanson, Katherine L

AU - Cortessis, Victoria K

AU - Hoadley, Katherine A

AU - Cancer Genome Atlas Research Network

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/6/12

Y1 - 2018/6/12

N2 - We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas.

AB - We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number. We report potential biomarkers for risk stratification, such as miRNA specifically expressed in teratoma, and others with molecular diagnostic potential, such as CpH (CpA/CpC/CpT) methylation identifying embryonal carcinomas.

KW - Journal Article

U2 - 10.1016/j.celrep.2018.05.039

DO - 10.1016/j.celrep.2018.05.039

M3 - SCORING: Journal article

C2 - 29898407

VL - 23

SP - 3392

EP - 3406

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 11

ER -