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Insulin-like factor 3 levels in cord blood and serum from children

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Insulin-like factor 3 levels in cord blood and serum from children : effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. / Bay, Katrine; Virtanen, Helena E; Hartung, Stefan; Ivell, Richard; Main, Katharina M; Skakkebaek, Niels E; Andersson, Anna-Maria; Toppari, Jorma; Nordic Cryptorchidism Study Group.

in: J CLIN ENDOCR METAB, Jahrgang 92, Nr. 10, 01.10.2007, S. 4020-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bay, K, Virtanen, HE, Hartung, S, Ivell, R, Main, KM, Skakkebaek, NE, Andersson, A-M, Toppari, J & Nordic Cryptorchidism Study Group 2007, 'Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism', J CLIN ENDOCR METAB, Jg. 92, Nr. 10, S. 4020-7. https://doi.org/10.1210/jc.2007-0974

APA

Bay, K., Virtanen, H. E., Hartung, S., Ivell, R., Main, K. M., Skakkebaek, N. E., Andersson, A-M., Toppari, J., & Nordic Cryptorchidism Study Group (2007). Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J CLIN ENDOCR METAB, 92(10), 4020-7. https://doi.org/10.1210/jc.2007-0974

Vancouver

Bay K, Virtanen HE, Hartung S, Ivell R, Main KM, Skakkebaek NE et al. Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J CLIN ENDOCR METAB. 2007 Okt 1;92(10):4020-7. https://doi.org/10.1210/jc.2007-0974

Bibtex

@article{9e584a4e879c47379fc3a5e0720e3c81,
title = "Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism",
abstract = "CONTEXT: The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown.OBJECTIVE: The objective of the study was to characterize INSL3 levels in cord blood during the postnatal activation of the hypothalamic-pituitary-gonadal axis and in later childhood in normal boys and girls and cryptorchid boys.DESIGN AND PARTICIPANTS: Serum from 267 3-month-old boys of a prospective study with standardized cryptorchidism classification was analyzed for INSL3 (of these, 99 also had cord blood samples). Testicular position was known in 151 controls and 54 transiently cryptorchid and 62 persistently cryptorchid subjects. Eight infant girls, 26 boys (4.1-10.1 yr), and 13 girls (3.7-8.7 yr) were also included.OUTCOME MEASURE: INSL3, age, testicular position, LH, and testosterone were measured.RESULTS: INSL3 levels were significantly higher (P < 0.001) in cord blood and 3-month-old boys as compared with older prepubertal boys. At 3 months of age, INSL3 correlated significantly with LH in healthy boys. Cord blood INSL3 was significantly reduced in persistently cryptorchid boys (P = 0.001), and 3-month-old persistently cryptorchid boys had a significantly increased LH to INSL3 ratio (P = 0.014). INSL3 was unmeasurable in girls at all ages.CONCLUSIONS: In boys, early postnatal INSL3 is markedly higher as compared with later childhood, presumably because it is stimulated by the transient postnatal LH peak. INSL3 was unmeasurable in girls at all ages. Reduced cord blood INSL3 and an increased LH to INSL3 ratio at 3 months of age in persistently cryptorchid boys suggest impaired Leydig cell function in cryptorchid boys already in the perinatal period.",
keywords = "Age Factors, Child, Child, Preschool, Cryptorchidism, Female, Fetal Blood, Humans, Hypothalamo-Hypophyseal System, Infant, Newborn, Insulin, Leydig Cells, Luteinizing Hormone, Male, Proteins, Testis, Testosterone",
author = "Katrine Bay and Virtanen, {Helena E} and Stefan Hartung and Richard Ivell and Main, {Katharina M} and Skakkebaek, {Niels E} and Anna-Maria Andersson and Jorma Toppari and {Nordic Cryptorchidism Study Group}",
year = "2007",
month = oct,
day = "1",
doi = "10.1210/jc.2007-0974",
language = "English",
volume = "92",
pages = "4020--7",
journal = "J CLIN ENDOCR METAB",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "10",

}

RIS

TY - JOUR

T1 - Insulin-like factor 3 levels in cord blood and serum from children

T2 - effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism

AU - Bay, Katrine

AU - Virtanen, Helena E

AU - Hartung, Stefan

AU - Ivell, Richard

AU - Main, Katharina M

AU - Skakkebaek, Niels E

AU - Andersson, Anna-Maria

AU - Toppari, Jorma

AU - Nordic Cryptorchidism Study Group

PY - 2007/10/1

Y1 - 2007/10/1

N2 - CONTEXT: The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown.OBJECTIVE: The objective of the study was to characterize INSL3 levels in cord blood during the postnatal activation of the hypothalamic-pituitary-gonadal axis and in later childhood in normal boys and girls and cryptorchid boys.DESIGN AND PARTICIPANTS: Serum from 267 3-month-old boys of a prospective study with standardized cryptorchidism classification was analyzed for INSL3 (of these, 99 also had cord blood samples). Testicular position was known in 151 controls and 54 transiently cryptorchid and 62 persistently cryptorchid subjects. Eight infant girls, 26 boys (4.1-10.1 yr), and 13 girls (3.7-8.7 yr) were also included.OUTCOME MEASURE: INSL3, age, testicular position, LH, and testosterone were measured.RESULTS: INSL3 levels were significantly higher (P < 0.001) in cord blood and 3-month-old boys as compared with older prepubertal boys. At 3 months of age, INSL3 correlated significantly with LH in healthy boys. Cord blood INSL3 was significantly reduced in persistently cryptorchid boys (P = 0.001), and 3-month-old persistently cryptorchid boys had a significantly increased LH to INSL3 ratio (P = 0.014). INSL3 was unmeasurable in girls at all ages.CONCLUSIONS: In boys, early postnatal INSL3 is markedly higher as compared with later childhood, presumably because it is stimulated by the transient postnatal LH peak. INSL3 was unmeasurable in girls at all ages. Reduced cord blood INSL3 and an increased LH to INSL3 ratio at 3 months of age in persistently cryptorchid boys suggest impaired Leydig cell function in cryptorchid boys already in the perinatal period.

AB - CONTEXT: The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown.OBJECTIVE: The objective of the study was to characterize INSL3 levels in cord blood during the postnatal activation of the hypothalamic-pituitary-gonadal axis and in later childhood in normal boys and girls and cryptorchid boys.DESIGN AND PARTICIPANTS: Serum from 267 3-month-old boys of a prospective study with standardized cryptorchidism classification was analyzed for INSL3 (of these, 99 also had cord blood samples). Testicular position was known in 151 controls and 54 transiently cryptorchid and 62 persistently cryptorchid subjects. Eight infant girls, 26 boys (4.1-10.1 yr), and 13 girls (3.7-8.7 yr) were also included.OUTCOME MEASURE: INSL3, age, testicular position, LH, and testosterone were measured.RESULTS: INSL3 levels were significantly higher (P < 0.001) in cord blood and 3-month-old boys as compared with older prepubertal boys. At 3 months of age, INSL3 correlated significantly with LH in healthy boys. Cord blood INSL3 was significantly reduced in persistently cryptorchid boys (P = 0.001), and 3-month-old persistently cryptorchid boys had a significantly increased LH to INSL3 ratio (P = 0.014). INSL3 was unmeasurable in girls at all ages.CONCLUSIONS: In boys, early postnatal INSL3 is markedly higher as compared with later childhood, presumably because it is stimulated by the transient postnatal LH peak. INSL3 was unmeasurable in girls at all ages. Reduced cord blood INSL3 and an increased LH to INSL3 ratio at 3 months of age in persistently cryptorchid boys suggest impaired Leydig cell function in cryptorchid boys already in the perinatal period.

KW - Age Factors

KW - Child

KW - Child, Preschool

KW - Cryptorchidism

KW - Female

KW - Fetal Blood

KW - Humans

KW - Hypothalamo-Hypophyseal System

KW - Infant, Newborn

KW - Insulin

KW - Leydig Cells

KW - Luteinizing Hormone

KW - Male

KW - Proteins

KW - Testis

KW - Testosterone

U2 - 10.1210/jc.2007-0974

DO - 10.1210/jc.2007-0974

M3 - SCORING: Journal article

C2 - 17666478

VL - 92

SP - 4020

EP - 4027

JO - J CLIN ENDOCR METAB

JF - J CLIN ENDOCR METAB

SN - 0021-972X

IS - 10

ER -