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Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

Standard

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I. / Fernandez, Ana M; Hernandez-Garzón, Edwin; Perez-Domper, Paloma; Perez-Alvarez, Alberto; Mederos, Sara; Matsui, Takashi; Santi, Andrea; Trueba-Saiz, Angel; García-Guerra, Lucía; Pose-Utrilla, Julia; Fielitz, Jens; Olson, Eric N; Fernandez de la Rosa, Ruben; Garcia Garcia, Luis; Pozo, Miguel Angel; Iglesias, Teresa; Araque, Alfonso; Soya, Hideaki; Perea, Gertrudis; Martin, Eduardo D; Torres Aleman, Ignacio.

in: DIABETES, Jahrgang 66, Nr. 1, 01.2017, S. 64-74.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fernandez, AM, Hernandez-Garzón, E, Perez-Domper, P, Perez-Alvarez, A, Mederos, S, Matsui, T, Santi, A, Trueba-Saiz, A, García-Guerra, L, Pose-Utrilla, J, Fielitz, J, Olson, EN, Fernandez de la Rosa, R, Garcia Garcia, L, Pozo, MA, Iglesias, T, Araque, A, Soya, H, Perea, G, Martin, ED & Torres Aleman, I 2017, 'Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I', DIABETES, Jg. 66, Nr. 1, S. 64-74. https://doi.org/10.2337/db16-0861

APA

Fernandez, A. M., Hernandez-Garzón, E., Perez-Domper, P., Perez-Alvarez, A., Mederos, S., Matsui, T., Santi, A., Trueba-Saiz, A., García-Guerra, L., Pose-Utrilla, J., Fielitz, J., Olson, E. N., Fernandez de la Rosa, R., Garcia Garcia, L., Pozo, M. A., Iglesias, T., Araque, A., Soya, H., Perea, G., ... Torres Aleman, I. (2017). Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I. DIABETES, 66(1), 64-74. https://doi.org/10.2337/db16-0861

Vancouver

Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T et al. Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I. DIABETES. 2017 Jan;66(1):64-74. https://doi.org/10.2337/db16-0861

Bibtex

@article{e8c4c2e98e884876acb38e72bc99ab09,
title = "Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I",
abstract = "Brain activity requires a flux of glucose to active regions to sustain increased metabolic demands. Insulin, the main regulator of glucose handling in the body, has been traditionally considered not to intervene in this process. However, we now report that insulin modulates brain glucose metabolism by acting on astrocytes in concert with IGF-I. The cooperation of insulin and IGF-I is needed to recover neuronal activity after hypoglycemia. Analysis of underlying mechanisms show that the combined action of IGF-I and insulin synergistically stimulates a mitogen-activated protein kinase/protein kinase D pathway resulting in translocation of GLUT1 to the cell membrane through multiple protein-protein interactions involving the scaffolding protein GAIP-interacting protein C terminus and the GTPase RAC1. Our observations identify insulin-like peptides as physiological modulators of brain glucose handling, providing further support to consider the brain as a target organ in diabetes.",
author = "Fernandez, {Ana M} and Edwin Hernandez-Garz{\'o}n and Paloma Perez-Domper and Alberto Perez-Alvarez and Sara Mederos and Takashi Matsui and Andrea Santi and Angel Trueba-Saiz and Luc{\'i}a Garc{\'i}a-Guerra and Julia Pose-Utrilla and Jens Fielitz and Olson, {Eric N} and {Fernandez de la Rosa}, Ruben and {Garcia Garcia}, Luis and Pozo, {Miguel Angel} and Teresa Iglesias and Alfonso Araque and Hideaki Soya and Gertrudis Perea and Martin, {Eduardo D} and {Torres Aleman}, Ignacio",
note = "{\textcopyright} 2017 by the American Diabetes Association.",
year = "2017",
month = jan,
doi = "10.2337/db16-0861",
language = "English",
volume = "66",
pages = "64--74",
journal = "DIABETES",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

AU - Fernandez, Ana M

AU - Hernandez-Garzón, Edwin

AU - Perez-Domper, Paloma

AU - Perez-Alvarez, Alberto

AU - Mederos, Sara

AU - Matsui, Takashi

AU - Santi, Andrea

AU - Trueba-Saiz, Angel

AU - García-Guerra, Lucía

AU - Pose-Utrilla, Julia

AU - Fielitz, Jens

AU - Olson, Eric N

AU - Fernandez de la Rosa, Ruben

AU - Garcia Garcia, Luis

AU - Pozo, Miguel Angel

AU - Iglesias, Teresa

AU - Araque, Alfonso

AU - Soya, Hideaki

AU - Perea, Gertrudis

AU - Martin, Eduardo D

AU - Torres Aleman, Ignacio

N1 - © 2017 by the American Diabetes Association.

PY - 2017/1

Y1 - 2017/1

N2 - Brain activity requires a flux of glucose to active regions to sustain increased metabolic demands. Insulin, the main regulator of glucose handling in the body, has been traditionally considered not to intervene in this process. However, we now report that insulin modulates brain glucose metabolism by acting on astrocytes in concert with IGF-I. The cooperation of insulin and IGF-I is needed to recover neuronal activity after hypoglycemia. Analysis of underlying mechanisms show that the combined action of IGF-I and insulin synergistically stimulates a mitogen-activated protein kinase/protein kinase D pathway resulting in translocation of GLUT1 to the cell membrane through multiple protein-protein interactions involving the scaffolding protein GAIP-interacting protein C terminus and the GTPase RAC1. Our observations identify insulin-like peptides as physiological modulators of brain glucose handling, providing further support to consider the brain as a target organ in diabetes.

AB - Brain activity requires a flux of glucose to active regions to sustain increased metabolic demands. Insulin, the main regulator of glucose handling in the body, has been traditionally considered not to intervene in this process. However, we now report that insulin modulates brain glucose metabolism by acting on astrocytes in concert with IGF-I. The cooperation of insulin and IGF-I is needed to recover neuronal activity after hypoglycemia. Analysis of underlying mechanisms show that the combined action of IGF-I and insulin synergistically stimulates a mitogen-activated protein kinase/protein kinase D pathway resulting in translocation of GLUT1 to the cell membrane through multiple protein-protein interactions involving the scaffolding protein GAIP-interacting protein C terminus and the GTPase RAC1. Our observations identify insulin-like peptides as physiological modulators of brain glucose handling, providing further support to consider the brain as a target organ in diabetes.

U2 - 10.2337/db16-0861

DO - 10.2337/db16-0861

M3 - SCORING: Journal article

C2 - 27999108

VL - 66

SP - 64

EP - 74

JO - DIABETES

JF - DIABETES

SN - 0012-1797

IS - 1

ER -