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Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine

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Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine. / Zhu, Danji; Jiang, Zhiwei; Li, Na; Wang, Xueting; Ren, Lingfei; Ye, Yuer; Pan, Yiqi; Yang, Guoli.

in: ADV DRUG DELIVER REV, Jahrgang 188, 114413, 09.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Zhu, D, Jiang, Z, Li, N, Wang, X, Ren, L, Ye, Y, Pan, Y & Yang, G 2022, 'Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine', ADV DRUG DELIVER REV, Jg. 188, 114413. https://doi.org/10.1016/j.addr.2022.114413

APA

Zhu, D., Jiang, Z., Li, N., Wang, X., Ren, L., Ye, Y., Pan, Y., & Yang, G. (2022). Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine. ADV DRUG DELIVER REV, 188, [114413]. https://doi.org/10.1016/j.addr.2022.114413

Vancouver

Zhu D, Jiang Z, Li N, Wang X, Ren L, Ye Y et al. Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine. ADV DRUG DELIVER REV. 2022 Sep;188. 114413. https://doi.org/10.1016/j.addr.2022.114413

Bibtex

@article{3696a60b12934307ab7c9944beb269d1,
title = "Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine",
abstract = "Various modifications have been performed on biomaterials to improve their applications in tissue engineering and regenerative medicine. However, the challenges of immunogenicity and biocompatibility existed since the application of biomaterials. As a method to solve this problem, the decellularization process removes most living cells from biomaterials to minimize their immunogenicity; and preserves the native structures and compositions that favour cell growth and the subsequent construction of functional tissue. On the other hand, genetic modification of biomaterials aims to achieve specific functions (low immunogenicity, osteogenesis, etc.) or analyse the genetic mechanisms underlying some diseases (cardiac dysfunction, liver fibrosis, etc.). The combination of decellularization and gene modification is highly superior to biomaterials; thus, we must obtain a deeper understanding of these novel biomaterials. In this review, we summarize the fabrication approaches and current applications of genetically modified decellularized biomaterials and then discuss their disadvantages and corresponding future perspectives.",
keywords = "Biocompatible Materials/chemistry, Extracellular Matrix/chemistry, Humans, Regenerative Medicine/methods, Tissue Engineering/methods, Tissue Scaffolds/chemistry",
author = "Danji Zhu and Zhiwei Jiang and Na Li and Xueting Wang and Lingfei Ren and Yuer Ye and Yiqi Pan and Guoli Yang",
note = "Copyright {\textcopyright} 2022 Elsevier B.V. All rights reserved.",
year = "2022",
month = sep,
doi = "10.1016/j.addr.2022.114413",
language = "English",
volume = "188",
journal = "ADV DRUG DELIVER REV",
issn = "0169-409X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine

AU - Zhu, Danji

AU - Jiang, Zhiwei

AU - Li, Na

AU - Wang, Xueting

AU - Ren, Lingfei

AU - Ye, Yuer

AU - Pan, Yiqi

AU - Yang, Guoli

N1 - Copyright © 2022 Elsevier B.V. All rights reserved.

PY - 2022/9

Y1 - 2022/9

N2 - Various modifications have been performed on biomaterials to improve their applications in tissue engineering and regenerative medicine. However, the challenges of immunogenicity and biocompatibility existed since the application of biomaterials. As a method to solve this problem, the decellularization process removes most living cells from biomaterials to minimize their immunogenicity; and preserves the native structures and compositions that favour cell growth and the subsequent construction of functional tissue. On the other hand, genetic modification of biomaterials aims to achieve specific functions (low immunogenicity, osteogenesis, etc.) or analyse the genetic mechanisms underlying some diseases (cardiac dysfunction, liver fibrosis, etc.). The combination of decellularization and gene modification is highly superior to biomaterials; thus, we must obtain a deeper understanding of these novel biomaterials. In this review, we summarize the fabrication approaches and current applications of genetically modified decellularized biomaterials and then discuss their disadvantages and corresponding future perspectives.

AB - Various modifications have been performed on biomaterials to improve their applications in tissue engineering and regenerative medicine. However, the challenges of immunogenicity and biocompatibility existed since the application of biomaterials. As a method to solve this problem, the decellularization process removes most living cells from biomaterials to minimize their immunogenicity; and preserves the native structures and compositions that favour cell growth and the subsequent construction of functional tissue. On the other hand, genetic modification of biomaterials aims to achieve specific functions (low immunogenicity, osteogenesis, etc.) or analyse the genetic mechanisms underlying some diseases (cardiac dysfunction, liver fibrosis, etc.). The combination of decellularization and gene modification is highly superior to biomaterials; thus, we must obtain a deeper understanding of these novel biomaterials. In this review, we summarize the fabrication approaches and current applications of genetically modified decellularized biomaterials and then discuss their disadvantages and corresponding future perspectives.

KW - Biocompatible Materials/chemistry

KW - Extracellular Matrix/chemistry

KW - Humans

KW - Regenerative Medicine/methods

KW - Tissue Engineering/methods

KW - Tissue Scaffolds/chemistry

U2 - 10.1016/j.addr.2022.114413

DO - 10.1016/j.addr.2022.114413

M3 - SCORING: Review article

C2 - 35777666

VL - 188

JO - ADV DRUG DELIVER REV

JF - ADV DRUG DELIVER REV

SN - 0169-409X

M1 - 114413

ER -