Inhibitory plasticity in a lateral band improves cortical detection of natural vocalizations.
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Inhibitory plasticity in a lateral band improves cortical detection of natural vocalizations. / Galindo-Leon, Edgar; Lin, Frank G; Liu, Robert C.
in: NEURON, Jahrgang 62, Nr. 5, 5, 2009, S. 705-716.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Inhibitory plasticity in a lateral band improves cortical detection of natural vocalizations.
AU - Galindo-Leon, Edgar
AU - Lin, Frank G
AU - Liu, Robert C
PY - 2009
Y1 - 2009
N2 - The interplay between excitation and inhibition in the auditory cortex is crucial for the processing of acoustic stimuli. However, the precise role that inhibition plays in the distributed cortical encoding of natural vocalizations has not been well studied. We recorded single units (SUs) and local field potentials (LFPs) in the awake mouse auditory cortex while presenting pup isolation calls to animals that either do (mothers) or do not (virgins) recognize the sounds as behaviorally relevant. In both groups, we observed substantial call-evoked inhibition. However, in mothers this was earlier, longer, stronger, and more stereotyped compared to virgins. This difference was most apparent for recording sites tuned to tone frequencies lower than the pup calls' high-ultrasonic frequency range. We hypothesize that this auditory cortical inhibitory plasticity improves pup call detection in a relatively specific manner by increasing the contrast between call-evoked responses arising from high-ultrasonic and lateral frequency neural populations.
AB - The interplay between excitation and inhibition in the auditory cortex is crucial for the processing of acoustic stimuli. However, the precise role that inhibition plays in the distributed cortical encoding of natural vocalizations has not been well studied. We recorded single units (SUs) and local field potentials (LFPs) in the awake mouse auditory cortex while presenting pup isolation calls to animals that either do (mothers) or do not (virgins) recognize the sounds as behaviorally relevant. In both groups, we observed substantial call-evoked inhibition. However, in mothers this was earlier, longer, stronger, and more stereotyped compared to virgins. This difference was most apparent for recording sites tuned to tone frequencies lower than the pup calls' high-ultrasonic frequency range. We hypothesize that this auditory cortical inhibitory plasticity improves pup call detection in a relatively specific manner by increasing the contrast between call-evoked responses arising from high-ultrasonic and lateral frequency neural populations.
KW - Animals
KW - Female
KW - Mice
KW - Animals, Newborn
KW - Behavior, Animal
KW - Action Potentials/physiology
KW - Spectrum Analysis
KW - Wakefulness
KW - Auditory Perception/physiology
KW - Acoustic Stimulation/methods
KW - Recognition (Psychology)
KW - Mice, Inbred DBA
KW - Reaction Time/physiology
KW - Auditory Cortex/cytology/physiology
KW - Evoked Potentials, Auditory/physiology
KW - Long-Term Synaptic Depression/physiology
KW - Neural Inhibition/physiology
KW - Sound
KW - Sound Localization
KW - Vocalization, Animal/physiology
KW - Animals
KW - Female
KW - Mice
KW - Animals, Newborn
KW - Behavior, Animal
KW - Action Potentials/physiology
KW - Spectrum Analysis
KW - Wakefulness
KW - Auditory Perception/physiology
KW - Acoustic Stimulation/methods
KW - Recognition (Psychology)
KW - Mice, Inbred DBA
KW - Reaction Time/physiology
KW - Auditory Cortex/cytology/physiology
KW - Evoked Potentials, Auditory/physiology
KW - Long-Term Synaptic Depression/physiology
KW - Neural Inhibition/physiology
KW - Sound
KW - Sound Localization
KW - Vocalization, Animal/physiology
M3 - SCORING: Journal article
VL - 62
SP - 705
EP - 716
JO - NEURON
JF - NEURON
SN - 0896-6273
IS - 5
M1 - 5
ER -
