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Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB

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Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. / Holliday, Holly; Roden, Daniel; Junankar, Simon; Wu, Sunny Z; Baker, Laura A; Krisp, Christoph; Chan, Chia-Ling; McFarland, Andrea; Skhinas, Joanna N; Cox, Thomas R; Pal, Bhupinder; Huntington, Nicholas D; Ormandy, Christopher J; Carroll, Jason S; Visvader, Jane; Molloy, Mark P; Swarbrick, Alexander.

in: ISCIENCE, Jahrgang 24, Nr. 2, 102072, 19.02.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Holliday, H, Roden, D, Junankar, S, Wu, SZ, Baker, LA, Krisp, C, Chan, C-L, McFarland, A, Skhinas, JN, Cox, TR, Pal, B, Huntington, ND, Ormandy, CJ, Carroll, JS, Visvader, J, Molloy, MP & Swarbrick, A 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', ISCIENCE, Jg. 24, Nr. 2, 102072. https://doi.org/10.1016/j.isci.2021.102072

APA

Holliday, H., Roden, D., Junankar, S., Wu, S. Z., Baker, L. A., Krisp, C., Chan, C-L., McFarland, A., Skhinas, J. N., Cox, T. R., Pal, B., Huntington, N. D., Ormandy, C. J., Carroll, J. S., Visvader, J., Molloy, M. P., & Swarbrick, A. (2021). Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. ISCIENCE, 24(2), [102072]. https://doi.org/10.1016/j.isci.2021.102072

Vancouver

Holliday H, Roden D, Junankar S, Wu SZ, Baker LA, Krisp C et al. Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. ISCIENCE. 2021 Feb 19;24(2). 102072. https://doi.org/10.1016/j.isci.2021.102072

Bibtex

@article{79d6d48b57204828adee588481ae8109,
title = "Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB",
abstract = "Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells; however, the mechanism by which it achieves this is unclear. Here, we show that ID4 has a cell autonomous role in preventing myoepithelial differentiation of basal cells in mammary organoids and in vivo. ID4 positively regulates proliferative genes and negatively regulates genes involved in myoepithelial function. Mass spectrometry reveals that ID4 interacts with the bHLH protein HEB, which binds to E-box motifs in regulatory elements of basal developmental genes involved in extracellular matrix and the contractile cytoskeleton. We conclude that high ID4 expression in mammary basal stem cells antagonizes HEB transcriptional activity, preventing myoepithelial differentiation and allowing for appropriate tissue morphogenesis. Downregulation of ID4 during pregnancy modulates gene regulated by HEB, promoting specialization of basal cells into myoepithelial cells.",
author = "Holly Holliday and Daniel Roden and Simon Junankar and Wu, {Sunny Z} and Baker, {Laura A} and Christoph Krisp and Chia-Ling Chan and Andrea McFarland and Skhinas, {Joanna N} and Cox, {Thomas R} and Bhupinder Pal and Huntington, {Nicholas D} and Ormandy, {Christopher J} and Carroll, {Jason S} and Jane Visvader and Molloy, {Mark P} and Alexander Swarbrick",
note = "{\textcopyright} 2021 The Author(s).",
year = "2021",
month = feb,
day = "19",
doi = "10.1016/j.isci.2021.102072",
language = "English",
volume = "24",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB

AU - Holliday, Holly

AU - Roden, Daniel

AU - Junankar, Simon

AU - Wu, Sunny Z

AU - Baker, Laura A

AU - Krisp, Christoph

AU - Chan, Chia-Ling

AU - McFarland, Andrea

AU - Skhinas, Joanna N

AU - Cox, Thomas R

AU - Pal, Bhupinder

AU - Huntington, Nicholas D

AU - Ormandy, Christopher J

AU - Carroll, Jason S

AU - Visvader, Jane

AU - Molloy, Mark P

AU - Swarbrick, Alexander

N1 - © 2021 The Author(s).

PY - 2021/2/19

Y1 - 2021/2/19

N2 - Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells; however, the mechanism by which it achieves this is unclear. Here, we show that ID4 has a cell autonomous role in preventing myoepithelial differentiation of basal cells in mammary organoids and in vivo. ID4 positively regulates proliferative genes and negatively regulates genes involved in myoepithelial function. Mass spectrometry reveals that ID4 interacts with the bHLH protein HEB, which binds to E-box motifs in regulatory elements of basal developmental genes involved in extracellular matrix and the contractile cytoskeleton. We conclude that high ID4 expression in mammary basal stem cells antagonizes HEB transcriptional activity, preventing myoepithelial differentiation and allowing for appropriate tissue morphogenesis. Downregulation of ID4 during pregnancy modulates gene regulated by HEB, promoting specialization of basal cells into myoepithelial cells.

AB - Inhibitor of differentiation (ID) proteins dimerize with basic HLH (bHLH) transcription factors, repressing transcription of lineage-specification genes across diverse cellular lineages. ID4 is a key regulator of mammary stem cells; however, the mechanism by which it achieves this is unclear. Here, we show that ID4 has a cell autonomous role in preventing myoepithelial differentiation of basal cells in mammary organoids and in vivo. ID4 positively regulates proliferative genes and negatively regulates genes involved in myoepithelial function. Mass spectrometry reveals that ID4 interacts with the bHLH protein HEB, which binds to E-box motifs in regulatory elements of basal developmental genes involved in extracellular matrix and the contractile cytoskeleton. We conclude that high ID4 expression in mammary basal stem cells antagonizes HEB transcriptional activity, preventing myoepithelial differentiation and allowing for appropriate tissue morphogenesis. Downregulation of ID4 during pregnancy modulates gene regulated by HEB, promoting specialization of basal cells into myoepithelial cells.

U2 - 10.1016/j.isci.2021.102072

DO - 10.1016/j.isci.2021.102072

M3 - SCORING: Journal article

C2 - 33554073

VL - 24

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

IS - 2

M1 - 102072

ER -