Inhibition of intestinal absorption and decorporation of radiocaesium in humans by hexacyanoferrates(II).
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Inhibition of intestinal absorption and decorporation of radiocaesium in humans by hexacyanoferrates(II). / Nielsen, Peter; Dresow, B; Fischer, R; Heinrich, H C.
in: Int J Rad Appl Instrum B, Jahrgang 18, Nr. 7, 7, 1991, S. 821-826.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Inhibition of intestinal absorption and decorporation of radiocaesium in humans by hexacyanoferrates(II).
AU - Nielsen, Peter
AU - Dresow, B
AU - Fischer, R
AU - Heinrich, H C
PY - 1991
Y1 - 1991
N2 - The effect of hexacyanoferrate(II) preparations, KFe[Fe(CN)6], (KFeHCF) anol Fe4[Fe(CN)6]3, (FeHCF) on intestinal radiocaesium absorption was studied in two male volunteers. The 134Cs absorption was decreased from 100 to 3-10% when 500-1000 mg KFeHCF or FeHCF were administered 10 min before the 134Cs-labelled test meal. However, when HCF was administered simultaneously with the test meal, the 134Cs absorption was decreased to only 38-63%. The biological half-time of previously absorbed 134Cs was reduced from 106 (73) to 44 (46) days by daily administration of 3 times 0.5 g KFeHCF. The 134Cs dose conversion factors lie below the values recommended by IRCP 30, indicating that the IRCP model represents a cautious description of the Cs biokinetics in our study.
AB - The effect of hexacyanoferrate(II) preparations, KFe[Fe(CN)6], (KFeHCF) anol Fe4[Fe(CN)6]3, (FeHCF) on intestinal radiocaesium absorption was studied in two male volunteers. The 134Cs absorption was decreased from 100 to 3-10% when 500-1000 mg KFeHCF or FeHCF were administered 10 min before the 134Cs-labelled test meal. However, when HCF was administered simultaneously with the test meal, the 134Cs absorption was decreased to only 38-63%. The biological half-time of previously absorbed 134Cs was reduced from 106 (73) to 44 (46) days by daily administration of 3 times 0.5 g KFeHCF. The 134Cs dose conversion factors lie below the values recommended by IRCP 30, indicating that the IRCP model represents a cautious description of the Cs biokinetics in our study.
M3 - SCORING: Zeitschriftenaufsatz
VL - 18
SP - 821
EP - 826
IS - 7
M1 - 7
ER -