Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis.
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Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis. / Sanchez-Juan, Pascual; Sánchez-Valle, Raquel; Green, Alison; Ladogana, Anna; Cuadrado-Corrales, Natividad; Mitrová, Eva; Stoeck, Katharina; Sklaviadis, Theodoros; Kulczycki, Jerzy; Hess, Klaus; Krasnianski, Anna; Equestre, Michele; Slivarichová, Danka; Saiz, Albert; Calero, Miguel; Pocchiari, Maurizio; Knight, Richard; Duijn, van; Cornelia, M; Zerr, Inga.
in: J NEUROL, Jahrgang 254, Nr. 7, 7, 2007, S. 901-906.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis.
AU - Sanchez-Juan, Pascual
AU - Sánchez-Valle, Raquel
AU - Green, Alison
AU - Ladogana, Anna
AU - Cuadrado-Corrales, Natividad
AU - Mitrová, Eva
AU - Stoeck, Katharina
AU - Sklaviadis, Theodoros
AU - Kulczycki, Jerzy
AU - Hess, Klaus
AU - Krasnianski, Anna
AU - Equestre, Michele
AU - Slivarichová, Danka
AU - Saiz, Albert
AU - Calero, Miguel
AU - Pocchiari, Maurizio
AU - Knight, Richard
AU - Duijn, van
AU - Cornelia, M
AU - Zerr, Inga
PY - 2007
Y1 - 2007
N2 - BACKGROUND : The analysis of markers in the cerebrospinal fluid (CSF) is useful in the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). However, the time at which the study of these markers is most sensitive remains controversal. OBJECTIVE : To assess the influence of time of sampling on the value of CSF tests in the diagnosis of sCJD. METHOD : In the framework of a multinational European study, we studied the results of 14-3-3, S100b, neurone specific enolase (NSE) and tau protein in 833 CSF samples from sCJD patients at different stages of disease and in 66 sequentially repeated lumbar punctures (LP). RESULTS : 14-3-3 and tau protein tended to increase in sensitivity from onset (88%, 81%) to the advanced stage (91%, 90%). This was significant only in the methionine-valine (MV) heterozygous group of patients at codon 129. The absolute levels of S100b (p <0.05), NSE and tau protein increased in the last stage of disease. High levels of tau protein, NSE and S100b were associated with shorter survival times (p <0.01). Sixty-six sCJD patients underwent repeated LP. These sCJD patients were younger, had longer disease durations and were more frequently MV at codon 129 (p <0.001) than the whole group. 14-3-3 sensitivity increased from 64% to 82% in the second LP (p = 0.025) and 88% sCJD patients had at least one positive result. CONCLUSIONS : Sensitivity and absolute levels of CJD markers increased with disease progression and were modulated by the codon 129 genotype. Early negative results should be inter-preted with caution, especially in young patients or those who are MV at codon 129.
AB - BACKGROUND : The analysis of markers in the cerebrospinal fluid (CSF) is useful in the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). However, the time at which the study of these markers is most sensitive remains controversal. OBJECTIVE : To assess the influence of time of sampling on the value of CSF tests in the diagnosis of sCJD. METHOD : In the framework of a multinational European study, we studied the results of 14-3-3, S100b, neurone specific enolase (NSE) and tau protein in 833 CSF samples from sCJD patients at different stages of disease and in 66 sequentially repeated lumbar punctures (LP). RESULTS : 14-3-3 and tau protein tended to increase in sensitivity from onset (88%, 81%) to the advanced stage (91%, 90%). This was significant only in the methionine-valine (MV) heterozygous group of patients at codon 129. The absolute levels of S100b (p <0.05), NSE and tau protein increased in the last stage of disease. High levels of tau protein, NSE and S100b were associated with shorter survival times (p <0.01). Sixty-six sCJD patients underwent repeated LP. These sCJD patients were younger, had longer disease durations and were more frequently MV at codon 129 (p <0.001) than the whole group. 14-3-3 sensitivity increased from 64% to 82% in the second LP (p = 0.025) and 88% sCJD patients had at least one positive result. CONCLUSIONS : Sensitivity and absolute levels of CJD markers increased with disease progression and were modulated by the codon 129 genotype. Early negative results should be inter-preted with caution, especially in young patients or those who are MV at codon 129.
M3 - SCORING: Zeitschriftenaufsatz
VL - 254
SP - 901
EP - 906
JO - J NEUROL
JF - J NEUROL
SN - 0340-5354
IS - 7
M1 - 7
ER -
