Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H.
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Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H. / Dubben, H H; Beck-Bornholdt, Hans-Peter.
in: ACTA ONCOL, Jahrgang 32, Nr. 1, 1, 1993, S. 79-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Influence of the timing of a concomitant boost during fractionated irradiation of rat rhabdomyosarcoma R1H.
AU - Dubben, H H
AU - Beck-Bornholdt, Hans-Peter
PY - 1993
Y1 - 1993
N2 - Rhabdomyosarcomas R1H of the rat (WAG/Rij) were treated using fractionation schedules including a boost. The total dose was 60 Gy. Overall treatment time was 6 weeks. Four different boost schedules were applied: a single dose boost (12.15 Gy) at the last day of treatment, a single dose boost (12.15 Gy) at the first day of treatment, a schedule including the boost in 7 fractions during the first week, and a schedule including the boost in 10 fractions during the first week of treatment. A standard schedule with 30 fractions of 2 Gy without a boost was used for comparison. Initially accelerated schedules, i.e. those with a boost at start of treatment, revealed higher effect on tumour parenchyma as monitored by local control rate and net growth delay. This could be due to a decrease of radio-sensitivity, that is, an increase of the hypoxic fraction of clonogenic tumour cells during fractionated irradiation.
AB - Rhabdomyosarcomas R1H of the rat (WAG/Rij) were treated using fractionation schedules including a boost. The total dose was 60 Gy. Overall treatment time was 6 weeks. Four different boost schedules were applied: a single dose boost (12.15 Gy) at the last day of treatment, a single dose boost (12.15 Gy) at the first day of treatment, a schedule including the boost in 7 fractions during the first week, and a schedule including the boost in 10 fractions during the first week of treatment. A standard schedule with 30 fractions of 2 Gy without a boost was used for comparison. Initially accelerated schedules, i.e. those with a boost at start of treatment, revealed higher effect on tumour parenchyma as monitored by local control rate and net growth delay. This could be due to a decrease of radio-sensitivity, that is, an increase of the hypoxic fraction of clonogenic tumour cells during fractionated irradiation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 32
SP - 79
EP - 82
JO - ACTA ONCOL
JF - ACTA ONCOL
SN - 0284-186X
IS - 1
M1 - 1
ER -
