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Influence of sex and genetic variability on expression of X-linked genes in human monocytes

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Influence of sex and genetic variability on expression of X-linked genes in human monocytes. / Castagné, Raphaële; Zeller, Tanja; Rotival, Maxime; Szymczak, Silke; Truong, Vinh; Schillert, Arne; Trégouët, David-Alexandre; Münzel, Thomas; Ziegler, Andreas; Cambien, François; Blankenberg, Stefan; Tiret, Laurence.

in: GENOMICS, Jahrgang 98, Nr. 5, 11.2011, S. 320-326.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Castagné, R, Zeller, T, Rotival, M, Szymczak, S, Truong, V, Schillert, A, Trégouët, D-A, Münzel, T, Ziegler, A, Cambien, F, Blankenberg, S & Tiret, L 2011, 'Influence of sex and genetic variability on expression of X-linked genes in human monocytes', GENOMICS, Jg. 98, Nr. 5, S. 320-326. https://doi.org/10.1016/j.ygeno.2011.06.009

APA

Castagné, R., Zeller, T., Rotival, M., Szymczak, S., Truong, V., Schillert, A., Trégouët, D-A., Münzel, T., Ziegler, A., Cambien, F., Blankenberg, S., & Tiret, L. (2011). Influence of sex and genetic variability on expression of X-linked genes in human monocytes. GENOMICS, 98(5), 320-326. https://doi.org/10.1016/j.ygeno.2011.06.009

Vancouver

Castagné R, Zeller T, Rotival M, Szymczak S, Truong V, Schillert A et al. Influence of sex and genetic variability on expression of X-linked genes in human monocytes. GENOMICS. 2011 Nov;98(5):320-326. https://doi.org/10.1016/j.ygeno.2011.06.009

Bibtex

@article{d4e9c8e3256a49fb916e2c3a8e8c643a,
title = "Influence of sex and genetic variability on expression of X-linked genes in human monocytes",
abstract = "In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and found an excess of female-biased transcripts on the X compared to autosomes (9.4% vs 5.5%, p<2×10(-5)). Among the genes not previously known to escape inactivation, the most significant one was EFHC2 whose 20% of variability was explained by sex. We also investigated cis expression quantitative trait loci (eQTLs) by analyzing 15,703 X-linked SNPs. The frequency and magnitude of X-linked cis eQTLs were quite similar in males and females. Few genes exhibited a stronger genetic effect in females than in males (ARSD, DCX, POLA1 and ITM2A). These genes would deserve further investigation since they may contribute to sex pathophysiological differences.",
keywords = "Adult, Aged, Calcium-Binding Proteins/genetics, Chromosomes, Human, X/genetics, Female, Genes, X-Linked, Genetic Variation, Genome-Wide Association Study, Humans, Male, Middle Aged, Monocytes/cytology, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sex Factors, Transcription, Genetic, X Chromosome Inactivation",
author = "Rapha{\"e}le Castagn{\'e} and Tanja Zeller and Maxime Rotival and Silke Szymczak and Vinh Truong and Arne Schillert and David-Alexandre Tr{\'e}gou{\"e}t and Thomas M{\"u}nzel and Andreas Ziegler and Fran{\c c}ois Cambien and Stefan Blankenberg and Laurence Tiret",
note = "Copyright {\^A}{\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = nov,
doi = "10.1016/j.ygeno.2011.06.009",
language = "English",
volume = "98",
pages = "320--326",
number = "5",

}

RIS

TY - JOUR

T1 - Influence of sex and genetic variability on expression of X-linked genes in human monocytes

AU - Castagné, Raphaële

AU - Zeller, Tanja

AU - Rotival, Maxime

AU - Szymczak, Silke

AU - Truong, Vinh

AU - Schillert, Arne

AU - Trégouët, David-Alexandre

AU - Münzel, Thomas

AU - Ziegler, Andreas

AU - Cambien, François

AU - Blankenberg, Stefan

AU - Tiret, Laurence

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/11

Y1 - 2011/11

N2 - In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and found an excess of female-biased transcripts on the X compared to autosomes (9.4% vs 5.5%, p<2×10(-5)). Among the genes not previously known to escape inactivation, the most significant one was EFHC2 whose 20% of variability was explained by sex. We also investigated cis expression quantitative trait loci (eQTLs) by analyzing 15,703 X-linked SNPs. The frequency and magnitude of X-linked cis eQTLs were quite similar in males and females. Few genes exhibited a stronger genetic effect in females than in males (ARSD, DCX, POLA1 and ITM2A). These genes would deserve further investigation since they may contribute to sex pathophysiological differences.

AB - In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and found an excess of female-biased transcripts on the X compared to autosomes (9.4% vs 5.5%, p<2×10(-5)). Among the genes not previously known to escape inactivation, the most significant one was EFHC2 whose 20% of variability was explained by sex. We also investigated cis expression quantitative trait loci (eQTLs) by analyzing 15,703 X-linked SNPs. The frequency and magnitude of X-linked cis eQTLs were quite similar in males and females. Few genes exhibited a stronger genetic effect in females than in males (ARSD, DCX, POLA1 and ITM2A). These genes would deserve further investigation since they may contribute to sex pathophysiological differences.

KW - Adult

KW - Aged

KW - Calcium-Binding Proteins/genetics

KW - Chromosomes, Human, X/genetics

KW - Female

KW - Genes, X-Linked

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Monocytes/cytology

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Sex Factors

KW - Transcription, Genetic

KW - X Chromosome Inactivation

U2 - 10.1016/j.ygeno.2011.06.009

DO - 10.1016/j.ygeno.2011.06.009

M3 - SCORING: Journal article

C2 - 21763416

VL - 98

SP - 320

EP - 326

IS - 5

ER -