PortalPublikationenInfluence of ROI definition on the heart-to-mediastinum rati...

Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging

Standard

Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging. / Klene, Christiane; Jungen, Christiane; Okuda, Koichi; Kobayashi, Yuske; Helberg, Annabelle; Mester, Janos; Meyer, Christian; Nakajima, Kenichi.

in: J NUCL CARDIOL, Jahrgang 25, Nr. 1, 02.2018, S. 208-216.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Klene, C, Jungen, C, Okuda, K, Kobayashi, Y, Helberg, A, Mester, J, Meyer, C & Nakajima, K 2018, 'Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging', J NUCL CARDIOL, Jg. 25, Nr. 1, S. 208-216. https://doi.org/10.1007/s12350-016-0708-8

APA

Klene, C., Jungen, C., Okuda, K., Kobayashi, Y., Helberg, A., Mester, J., Meyer, C., & Nakajima, K. (2018). Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging. J NUCL CARDIOL, 25(1), 208-216. https://doi.org/10.1007/s12350-016-0708-8

Vancouver

Klene C, Jungen C, Okuda K, Kobayashi Y, Helberg A, Mester J et al. Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging. J NUCL CARDIOL. 2018 Feb;25(1):208-216. https://doi.org/10.1007/s12350-016-0708-8

Bibtex

@article{ef2ebb34d5b748119db7229a31d60a6a,
title = "Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging",
abstract = "BACKGROUND: Iodine-123-metaiodobenzylguanidine (123I-MIBG) imaging with estimation of the heart-to-mediastinum ratio (HMR) has been established for risk assessment in patients with chronic heart failure. Our aim was to evaluate the effect of different methods of ROI definition on the renderability of HMR to normal or decreased sympathetic innervation.METHODS AND RESULTS: The results of three different methods of ROI definition (clinical routine (CLI), simple standardization (STA), and semi-automated (AUT) were compared. Ranges of 95% limits of agreement (LoA) of inter-observer variabilities were 0.28 and 0.13 for STA and AUT, respectively. Considering a HMR of 1.60 as the lower limit of normal, 13 of 32 (41%) for method STA and 5 of 32 (16%) for method AUT of all HMR measurements could not be classified to normal or pathologic. Ranges of 95% LoA of inter-method variabilities were 0.72 for CLI vs AUT, 0.65 for CLI vs STA, and 0.31 for STA vs AUT.CONCLUSION: Different methods of ROI definition result in different ranges of the LoA of the measured HMR with relevance for rendering the results to normal or pathological innervation. We could demonstrate that standardized protocols can help keep methodological variabilities limited, narrowing the gray zone of renderability.",
keywords = "Journal Article",
author = "Christiane Klene and Christiane Jungen and Koichi Okuda and Yuske Kobayashi and Annabelle Helberg and Janos Mester and Christian Meyer and Kenichi Nakajima",
year = "2018",
month = feb,
doi = "10.1007/s12350-016-0708-8",
language = "English",
volume = "25",
pages = "208--216",
journal = "J NUCL CARDIOL",
issn = "1071-3581",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Influence of ROI definition on the heart-to-mediastinum ratio in planar I-MIBG imaging

AU - Klene, Christiane

AU - Jungen, Christiane

AU - Okuda, Koichi

AU - Kobayashi, Yuske

AU - Helberg, Annabelle

AU - Mester, Janos

AU - Meyer, Christian

AU - Nakajima, Kenichi

PY - 2018/2

Y1 - 2018/2

N2 - BACKGROUND: Iodine-123-metaiodobenzylguanidine (123I-MIBG) imaging with estimation of the heart-to-mediastinum ratio (HMR) has been established for risk assessment in patients with chronic heart failure. Our aim was to evaluate the effect of different methods of ROI definition on the renderability of HMR to normal or decreased sympathetic innervation.METHODS AND RESULTS: The results of three different methods of ROI definition (clinical routine (CLI), simple standardization (STA), and semi-automated (AUT) were compared. Ranges of 95% limits of agreement (LoA) of inter-observer variabilities were 0.28 and 0.13 for STA and AUT, respectively. Considering a HMR of 1.60 as the lower limit of normal, 13 of 32 (41%) for method STA and 5 of 32 (16%) for method AUT of all HMR measurements could not be classified to normal or pathologic. Ranges of 95% LoA of inter-method variabilities were 0.72 for CLI vs AUT, 0.65 for CLI vs STA, and 0.31 for STA vs AUT.CONCLUSION: Different methods of ROI definition result in different ranges of the LoA of the measured HMR with relevance for rendering the results to normal or pathological innervation. We could demonstrate that standardized protocols can help keep methodological variabilities limited, narrowing the gray zone of renderability.

AB - BACKGROUND: Iodine-123-metaiodobenzylguanidine (123I-MIBG) imaging with estimation of the heart-to-mediastinum ratio (HMR) has been established for risk assessment in patients with chronic heart failure. Our aim was to evaluate the effect of different methods of ROI definition on the renderability of HMR to normal or decreased sympathetic innervation.METHODS AND RESULTS: The results of three different methods of ROI definition (clinical routine (CLI), simple standardization (STA), and semi-automated (AUT) were compared. Ranges of 95% limits of agreement (LoA) of inter-observer variabilities were 0.28 and 0.13 for STA and AUT, respectively. Considering a HMR of 1.60 as the lower limit of normal, 13 of 32 (41%) for method STA and 5 of 32 (16%) for method AUT of all HMR measurements could not be classified to normal or pathologic. Ranges of 95% LoA of inter-method variabilities were 0.72 for CLI vs AUT, 0.65 for CLI vs STA, and 0.31 for STA vs AUT.CONCLUSION: Different methods of ROI definition result in different ranges of the LoA of the measured HMR with relevance for rendering the results to normal or pathological innervation. We could demonstrate that standardized protocols can help keep methodological variabilities limited, narrowing the gray zone of renderability.

KW - Journal Article

U2 - 10.1007/s12350-016-0708-8

DO - 10.1007/s12350-016-0708-8

M3 - SCORING: Journal article

C2 - 27804071

VL - 25

SP - 208

EP - 216

JO - J NUCL CARDIOL

JF - J NUCL CARDIOL

SN - 1071-3581

IS - 1

ER -