Influence of oral vitamin and mineral supplementation on male infertility
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Influence of oral vitamin and mineral supplementation on male infertility : a meta-analysis and systematic review. / Buhling, Kai; Schumacher, Annika; Eulenburg, Christine Zu; Laakmann, Elena.
in: REPROD BIOMED ONLINE, Jahrgang 39, Nr. 2, 08.2019, S. 269-279.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Influence of oral vitamin and mineral supplementation on male infertility
T2 - a meta-analysis and systematic review
AU - Buhling, Kai
AU - Schumacher, Annika
AU - Eulenburg, Christine Zu
AU - Laakmann, Elena
N1 - Copyright © 2019 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - This meta-analysis and systematic review investigated evidence of the effect of oral micronutrient supplementation on male fertility. Following searches of PubMed, Ovid/Ovid Medline(r) and Embase, 18 randomized, double-blind, placebo-controlled trials were included in the meta-analysis (seven studies) and/or the systematic review (12 studies). The meta-analysis showed significant improvement in semen parameters for selenium (200µg/day and 100µg/day) (standard mean difference [SMD] 0.64 for oligozoospermia, 1.39 for asthenozoospermia), L-carnitine (2 g/day) and acetyl-L-carnitine (LAC; 1 g/day) combined (SMD 0.57 for asthenozoospermia), and co-enzyme Q10 (200 and 300 mg/day) (SMD 0.95 for oligozoospermia, 1.48 for asthenozoospermia, 0.63 for teratozoospermia). The systematic review identified promising data for supplementation with 66 mg/day zinc combined with folic acid (5 mg/day), and the polyunsaturated fatty acids eicosapentaenoic acid (EPA; 1.12 g/day) and docosahexaenoic acid (DHA; 0.72 g/day). Pregnancy rate was evaluated in a limited number of trials (four in the meta-analysis, three in the systematic review). This analysis suggests supplementation with selenium (alone or combined with N-acetylcysteine), co-enzyme Q10 and the combinations L-carnitine + acetyl-L-carnitine, folic acid + zinc and EPA + DHA is beneficial in the treatment of male infertility. Because of the small number of available studies and low number of participants, further well-designed clinical studies are needed to obtain a better overview of efficient methods of treating male infertility.
AB - This meta-analysis and systematic review investigated evidence of the effect of oral micronutrient supplementation on male fertility. Following searches of PubMed, Ovid/Ovid Medline(r) and Embase, 18 randomized, double-blind, placebo-controlled trials were included in the meta-analysis (seven studies) and/or the systematic review (12 studies). The meta-analysis showed significant improvement in semen parameters for selenium (200µg/day and 100µg/day) (standard mean difference [SMD] 0.64 for oligozoospermia, 1.39 for asthenozoospermia), L-carnitine (2 g/day) and acetyl-L-carnitine (LAC; 1 g/day) combined (SMD 0.57 for asthenozoospermia), and co-enzyme Q10 (200 and 300 mg/day) (SMD 0.95 for oligozoospermia, 1.48 for asthenozoospermia, 0.63 for teratozoospermia). The systematic review identified promising data for supplementation with 66 mg/day zinc combined with folic acid (5 mg/day), and the polyunsaturated fatty acids eicosapentaenoic acid (EPA; 1.12 g/day) and docosahexaenoic acid (DHA; 0.72 g/day). Pregnancy rate was evaluated in a limited number of trials (four in the meta-analysis, three in the systematic review). This analysis suggests supplementation with selenium (alone or combined with N-acetylcysteine), co-enzyme Q10 and the combinations L-carnitine + acetyl-L-carnitine, folic acid + zinc and EPA + DHA is beneficial in the treatment of male infertility. Because of the small number of available studies and low number of participants, further well-designed clinical studies are needed to obtain a better overview of efficient methods of treating male infertility.
KW - Acetylcysteine/therapeutic use
KW - Administration, Oral
KW - Ascorbic Acid/therapeutic use
KW - Dietary Supplements
KW - Docosahexaenoic Acids/therapeutic use
KW - Eicosapentaenoic Acid/therapeutic use
KW - Folic Acid/therapeutic use
KW - Humans
KW - Infertility, Male/drug therapy
KW - Male
KW - Minerals/therapeutic use
KW - Randomized Controlled Trials as Topic
KW - Selenium/therapeutic use
KW - Spermatozoa/drug effects
KW - Ubiquinone/analogs & derivatives
KW - Vitamin E/therapeutic use
KW - Vitamins/therapeutic use
U2 - 10.1016/j.rbmo.2019.03.099
DO - 10.1016/j.rbmo.2019.03.099
M3 - SCORING: Journal article
C2 - 31160241
VL - 39
SP - 269
EP - 279
JO - REPROD BIOMED ONLINE
JF - REPROD BIOMED ONLINE
SN - 1472-6483
IS - 2
ER -
