Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer.
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Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer. / Dünne, A A; Gröbe, Alexander; Sesterhenn, A M; Barth, P; Dalchow, C; Werner, J A.
in: ANTICANCER RES, Jahrgang 25, Nr. 6, 6, 2005, S. 4129-4134.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Influence of matrix metalloproteinase 9 (MMP-9) on the metastatic behavior of oropharyngeal cancer.
AU - Dünne, A A
AU - Gröbe, Alexander
AU - Sesterhenn, A M
AU - Barth, P
AU - Dalchow, C
AU - Werner, J A
PY - 2005
Y1 - 2005
N2 - BACKGROUND: The role of the single matrix metalloproteinases (MMPs) in the metastatic process of squamous cell carcinomas (SCC) is still obscure. MATERIALS AND METHODS: The MMP-9 expression was described immunohistochemically in 105 patients (40-79 years of age, mean: 57.84 years; 84 male, 21 female) suffering from orophatyngeal cancer (22x TI, 31x T2, 24x T3, 28x T4) with different neck stages (41x N0, 6x N1, 54x N2, 4x N3 neck). RESULTS: A significant correlation between MMP-9 expression and T stage (p <0.05), N stage (r = 0.55, p <0.01) and UICC stage (r = 0.55, p <0.01) was revealed. Most remarkable was the high MMP-9 expression with simultaneously high UICC stages. CONCLUSION: The results give further indication that MMP-9 plays a role in the metastatic behavior of oropharyngeal SCC. It will be a project for the near future to create a standardized evaluation score of immuno-histological stainings to allow valid comparison of the results and published data.
AB - BACKGROUND: The role of the single matrix metalloproteinases (MMPs) in the metastatic process of squamous cell carcinomas (SCC) is still obscure. MATERIALS AND METHODS: The MMP-9 expression was described immunohistochemically in 105 patients (40-79 years of age, mean: 57.84 years; 84 male, 21 female) suffering from orophatyngeal cancer (22x TI, 31x T2, 24x T3, 28x T4) with different neck stages (41x N0, 6x N1, 54x N2, 4x N3 neck). RESULTS: A significant correlation between MMP-9 expression and T stage (p <0.05), N stage (r = 0.55, p <0.01) and UICC stage (r = 0.55, p <0.01) was revealed. Most remarkable was the high MMP-9 expression with simultaneously high UICC stages. CONCLUSION: The results give further indication that MMP-9 plays a role in the metastatic behavior of oropharyngeal SCC. It will be a project for the near future to create a standardized evaluation score of immuno-histological stainings to allow valid comparison of the results and published data.
M3 - SCORING: Zeitschriftenaufsatz
VL - 25
SP - 4129
EP - 4134
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 6
M1 - 6
ER -
