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Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study

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Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study. / Gierth, Michael; Zeman, Florian; Denzinger, Stefan; Vetterlein, Malte W; Fisch, Margit; Bastian, Patrick J; Syring, Isabella; Ellinger, Jörg; Müller, Stephan C; Herrmann, Edwin; Gilfrich, Christian; May, Matthias; Pycha, Armin; Wagenlehner, Florian M; Vallo, Stefan; Bartsch, Georg; Haferkamp, Axel; Grimm, Marc-Oliver; Roigas, Jan; Protzel, Chris; Hakenberg, Oliver W; Fritsche, Hans-Martin; Burger, Maximilian; Aziz, Atiqullah; Mayr, Roman.

in: UROL INT, Jahrgang 101, Nr. 1, 06.2018, S. 16-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gierth, M, Zeman, F, Denzinger, S, Vetterlein, MW, Fisch, M, Bastian, PJ, Syring, I, Ellinger, J, Müller, SC, Herrmann, E, Gilfrich, C, May, M, Pycha, A, Wagenlehner, FM, Vallo, S, Bartsch, G, Haferkamp, A, Grimm, M-O, Roigas, J, Protzel, C, Hakenberg, OW, Fritsche, H-M, Burger, M, Aziz, A & Mayr, R 2018, 'Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study', UROL INT, Jg. 101, Nr. 1, S. 16-24. https://doi.org/10.1159/000488466

APA

Gierth, M., Zeman, F., Denzinger, S., Vetterlein, M. W., Fisch, M., Bastian, P. J., Syring, I., Ellinger, J., Müller, S. C., Herrmann, E., Gilfrich, C., May, M., Pycha, A., Wagenlehner, F. M., Vallo, S., Bartsch, G., Haferkamp, A., Grimm, M-O., Roigas, J., ... Mayr, R. (2018). Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study. UROL INT, 101(1), 16-24. https://doi.org/10.1159/000488466

Vancouver

Gierth M, Zeman F, Denzinger S, Vetterlein MW, Fisch M, Bastian PJ et al. Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study. UROL INT. 2018 Jun;101(1):16-24. https://doi.org/10.1159/000488466

Bibtex

@article{0b4d6b21d22d498898e5564a57e997e1,
title = "Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study",
abstract = "Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC).METHODS: Clinical and histopathological parameters of patients have been prospectively collected within the {"}PROspective MulticEnTer RadIcal Cystectomy Series 2011{"}. BMI was categorized as normal weight (<25 kg/m2), overweight (≥25-29.9 kg/m2) and obesity (≥30 kg/m2). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival.RESULTS: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the -American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019).CONCLUSIONS: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled -accordingly.",
keywords = "Journal Article",
author = "Michael Gierth and Florian Zeman and Stefan Denzinger and Vetterlein, {Malte W} and Margit Fisch and Bastian, {Patrick J} and Isabella Syring and J{\"o}rg Ellinger and M{\"u}ller, {Stephan C} and Edwin Herrmann and Christian Gilfrich and Matthias May and Armin Pycha and Wagenlehner, {Florian M} and Stefan Vallo and Georg Bartsch and Axel Haferkamp and Marc-Oliver Grimm and Jan Roigas and Chris Protzel and Hakenberg, {Oliver W} and Hans-Martin Fritsche and Maximilian Burger and Atiqullah Aziz and Roman Mayr",
note = "{\textcopyright} 2018 S. Karger AG, Basel.",
year = "2018",
month = jun,
doi = "10.1159/000488466",
language = "English",
volume = "101",
pages = "16--24",
journal = "UROL INT",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study

AU - Gierth, Michael

AU - Zeman, Florian

AU - Denzinger, Stefan

AU - Vetterlein, Malte W

AU - Fisch, Margit

AU - Bastian, Patrick J

AU - Syring, Isabella

AU - Ellinger, Jörg

AU - Müller, Stephan C

AU - Herrmann, Edwin

AU - Gilfrich, Christian

AU - May, Matthias

AU - Pycha, Armin

AU - Wagenlehner, Florian M

AU - Vallo, Stefan

AU - Bartsch, Georg

AU - Haferkamp, Axel

AU - Grimm, Marc-Oliver

AU - Roigas, Jan

AU - Protzel, Chris

AU - Hakenberg, Oliver W

AU - Fritsche, Hans-Martin

AU - Burger, Maximilian

AU - Aziz, Atiqullah

AU - Mayr, Roman

N1 - © 2018 S. Karger AG, Basel.

PY - 2018/6

Y1 - 2018/6

N2 - Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC).METHODS: Clinical and histopathological parameters of patients have been prospectively collected within the "PROspective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (<25 kg/m2), overweight (≥25-29.9 kg/m2) and obesity (≥30 kg/m2). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival.RESULTS: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the -American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019).CONCLUSIONS: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled -accordingly.

AB - Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC).METHODS: Clinical and histopathological parameters of patients have been prospectively collected within the "PROspective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (<25 kg/m2), overweight (≥25-29.9 kg/m2) and obesity (≥30 kg/m2). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival.RESULTS: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the -American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019).CONCLUSIONS: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled -accordingly.

KW - Journal Article

U2 - 10.1159/000488466

DO - 10.1159/000488466

M3 - SCORING: Journal article

C2 - 29719296

VL - 101

SP - 16

EP - 24

JO - UROL INT

JF - UROL INT

SN - 0042-1138

IS - 1

ER -