Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.
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Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation. / Fehse, Natalja; Fehse, Boris; Kröger, Nicolaus-Martin; Zabelina, Tatjana; Freiberger, Petra; Krüger, William; Kabisch, Hartmut; Erttmann, Rudolf; Zander, Axel.
in: J HEMATOTH STEM CELL, Jahrgang 12, Nr. 2, 2, 2003, S. 237-242.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.
AU - Fehse, Natalja
AU - Fehse, Boris
AU - Kröger, Nicolaus-Martin
AU - Zabelina, Tatjana
AU - Freiberger, Petra
AU - Krüger, William
AU - Kabisch, Hartmut
AU - Erttmann, Rudolf
AU - Zander, Axel
PY - 2003
Y1 - 2003
N2 - The aim of this work was to analyze the influence of anti-thymocyte globulin (ATG) as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation. The rate and pattern of the recovery of total lymphocytes, natural killer (NK) cells, and several T and B cell subsets were determined in 38 patients for more than 2 years following BMT. We compared two patient groups: the first comprised 19 patients after matched related BMT without ATG prevention for graft-versus-host disease (GVHD) and the second contained 19 patients after matched related BMT with ATG treatment for GVHD prophylaxis. We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT.
AB - The aim of this work was to analyze the influence of anti-thymocyte globulin (ATG) as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation. The rate and pattern of the recovery of total lymphocytes, natural killer (NK) cells, and several T and B cell subsets were determined in 38 patients for more than 2 years following BMT. We compared two patient groups: the first comprised 19 patients after matched related BMT without ATG prevention for graft-versus-host disease (GVHD) and the second contained 19 patients after matched related BMT with ATG treatment for GVHD prophylaxis. We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT.
M3 - SCORING: Zeitschriftenaufsatz
VL - 12
SP - 237
EP - 242
JO - J HEMATOTH STEM CELL
JF - J HEMATOTH STEM CELL
SN - 1525-8165
IS - 2
M1 - 2
ER -